Alpha Antagonists

Question 1

Acts nonselective on alpha

Answer 1

Phenoxybenzamine

Phentolamine

Question 2

Selective for alpha 1

Answer 2

Prazosin
Terazosin
Doxazosin
Tamsulosin

Question 3

Useful for HTN Tx

Answer 3

Prazosin
Terazosin
Doxazosin
Tamsulosin

Question 4

Acts on alpha 2

Answer 4

Yohimbine

Question 5

DOC pheochromocytoma

Answer 5

Phenozybenzamine

Question 6

Reversible alpha blocker

Answer 6

Phentolamine

Question 7

Irreversible alpha blocker

Answer 7

Phenoxybenzamine

Question 8

Used for sudden clonidine withdrawal

Answer 8

Phentolamine

Question 9

Tx for Tyramine with MAOI

Answer 9

Phentolamine

Question 10

Anti-HTN in stimulant OD

Answer 10

Phentolamine

Question 11

What receptors do Phenozybenxamine block/inhibit

Answer 11

H1
M
5HT
NET

Question 12

What receptors do Phentolamine block/inhibit

Answer 12

5HT

Question 13

What receptors do Phentolamine activate

Answer 13

H1, 2, M

Question 14

CVS effects of Phenoxybenzamine

Answer 14

Prevent vasoconstriction
Reflex tachy
Increase CO

Question 15

Phenoxybenzamine AE

Answer 15

Postural hypotention
Nasal stiffness
N/V
Inhibit ejaculation

Question 16

Contraindication of Phenoxybenzamine

Answer 16

Decreased Coronary perfusion

Question 17

What is used for Dx and HTN crisis control of pheochromocytoma

Answer 17

Phentolamine

Question 18

What prevents dermal necrosis when NE extravasates

Answer 18

Phentolamine

Question 19

Contraindication of Phentolamine

Answer 19

Decreased Coronary perfusion

Question 20

Action of Prazosin

Answer 20

Decrease TPR (SM relax)

Question 21

What are Prazosin analogs with longer t1/2

Answer 21

Terazosin

Doxazosin

Question 22

Which alpha 1 blocker is selective for alpha1A in UG SM

Answer 22

Tamsulosin

Question 23

Which alpha 1 blocker decrease BP w/o reflex tachy

Answer 23

Prazosin
Terazosin
Doxazosin

Question 24

Which alpha 1 blocker decreases LDL/TAG and increases HDL

Answer 24

Prazosin
Terazosin
Doxazosin

Question 25

Tx of HTN and BPH

Answer 25

Prazosin Terazosin Doxazosin

Question 26

What treats BPH without affecting BP

Answer 26

Tamsulosin

Question 27

What can the first dose of alpha 1 blocker cause

Answer 27

Exaggerated hypotensive response and syncope

Question 28

AE for Phentolamine

Answer 28

``` Postural hypotention (baro reflex and alpha 2 block) Arrhythmia and angina ```

Question 29

Indirect adrenergic agonist

Answer 29

Yohimbine

Question 30

Causes NE release to increase BP

Answer 30

Yohimbine

Question 31

Tx erectile dysfunction (replaced by PDE-5i)

Answer 31

Yohimbine

Question 32

What do you not give Yohimbine with

Answer 32

Clonidine