Muscarinic Antagonists

Question 1

Belladonna Alkaloids

Answer 1

Atropine

Scopolamine

Question 2

QAC

Answer 2

Ipatropium
Tiotropium
Glycopyrrolate

Question 3

Tertiary Amines

Answer 3

Atropine
Scopolamine
Homatropine
Cyclopentolate
Topicamide
Beztropine
Trihexylphenidyl
Tolterodine

Question 4

DOC motion sickness

Answer 4

Scopolamine

Question 5

Decreases urinary hypermotility

Answer 5

Atropine

Question 6

Bradycardia in low dose (pre M2)

Tachycardia in higher dose (atrial M2)

Answer 6

Atropine

Question 7

CNS AE for muscarinic antagonists

Answer 7

Hallucinations
Delirium
Depression
Restlessness
Confusion

Question 8

DOC OD cholinergic

Answer 8

Atropine (farmer, insecticide)

Question 9

Eye effects of Atropine

Answer 9

Mydriasis
Cycloplegia
Unreactive to light

Question 10

GI effects of Atropine

Answer 10

Antispasmodic

Decrease motility

Question 11

Sympathetic effects of atropine

Answer 11

Salivary, sweat, lacrimal secretions blocked

Question 12

Blocks short term memory

Answer 12

Scopolamine

Question 13

Bronchodilation and which receptor

Answer 13

Ipratropium
Tiotropium
M3

Question 14

Shorter duration so use over Atropine

Answer 14

Homatropine
Cyclopentolate
Tropicamide

Question 15

Action of Benztropine and Trihexyphenidyl

Answer 15

Restore balance input after loss of DAergic neurons in Substantia Nigra

Question 16

SM relaxation

Answer 16

Tolteridine

Question 17

Decreases resp secretions prior to surgery

Answer 17

Atropine

Question 18

Increase HR or Decrease AV block due to excessive vagal tone

Answer 18

Atropine

Question 19

Use for death cap mushroom poisoning

Answer 19

Atropine

Question 20

Stop muscarinic side effects of AchE drugs

Answer 20

Atropine

Question 21

Inhaled

Answer 21

Ipratropium

Tiotropium

Question 22

Tx for COPD and asthma adjuvant

Answer 22

Ipratropium

Tiotropium

Question 23

Use for Parkinsonism or extrapyramidal effects (D2)

Answer 23

Beztropine

Trihexylphenidyl

Question 24

Prevent bradychardia in surgery

Answer 24

Glycopyrrolate (parenteral)

Question 25

Inhibit GI motility

Answer 25

Glycopyrrolate (oral)

Question 26

Used for overactive bladder

Answer 26

Tolterodine

Question 27

Atropine Flush

Answer 27

Cutaneous vasodilation

Question 28

Anti-PS AE muscarinic antagonists

Answer 28

``` Xerstomia Blurred vision Sandy eyes Tachycardia Constipation ```

Question 29

Effect of muscarinic antagonists on glaucoma

Answer 29

Exacerbation | Blindness

Question 30

Effect of muscarinic antagonists on BPH

Answer 30

Decreased detrusor contraction | Urinary retention

Question 31

AE of low levels muscarinic antagonists

Answer 31

Bradychardia | Sedation

Question 32

AE of high levels muscarinic antagonists

Answer 32

Tachycardia | CNS hyperexcitation

Question 33

What amines can enter CNS

Answer 33

Tertiary

Question 34

Metabolism site of atropine

Answer 34

Liver

Question 35

Excretion site of atropine

Answer 35

Kidney

Question 36

Longer duration in CNS than atropine

Answer 36

Scopolamine

Question 37

Cause Mydriasis and Cycloplegia

Answer 37

Homatropine Cyclopentolate Topicamide