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Flashcards in Diuretics Deck (54):
1

What are the loop diuretics

Furosemide
Toresemide

2

What are the thiazides

Chlorthalidone
Hydrochlorothiazide
Metolazone

3

What are the K sparing diuretics

Spironolactone
Eplerenone
Amiloride
Triamterene

4

What is the CAH inhibitor

Acetazolamide

5

What is the osmotic diuretic

Mannitol

6

What is the ADH antagonist and acts on V1 and 2

Conivaptan

7

What do loop diuretics act on

NKCC2

8

What do thiazides act on

NCCT

9

What acts as an aldosterone antagonist

Spironolactone
Eplerenone

10

What acts on ENaC

Amiloride
Triamterene

11

DOC for acute pulm edema with HF

Loop diuretics

12

HTN in DI

Thiazides

13

Main AE for Loop

Ototoxicity
Hypokalemia

14

Main AE for aldosterone agonists

Irregular menstrual cycle
gynecomastia
Impotence

15

Main AE for Acetazolamide

Metabolic acidosis

16

Main AE for Mannitol

Dehydration

17

What are the most effective diuretic

Loop

18

Which diuretic class decrease PVR and BP even after volume recovery

Thiazides

19

What are the sulfa derivatives

Thiazides

20

What is the NKCC2

Na/Cl/K cotransporter

21

Where do loops act

LOH duh

22

What increases PG synthesis via COX 2

Loop diuretics

23

Under what conditions can you give loop diuretic

Hypercalcemia
Hyperkalemia

24

What is the urine composition in a pt on loop diuretics

Increased Ca, Na, K, Mg, volume

25

What is the urine composition in a pt on thiazides

Increased Na, K, Cl, Mg, volume
Decreased Ca

26

AE of Loops

Hyperuricemia (since renal clearance is affected)
Acute hypovolemia
Hypomagnesemia
Allergies (sulfa)

27

What is NCCT

NA/Cl cotransporter

28

Where is NCCT

DCT

29

Do thiazides have a ceiling effect

Yes

30

When can you give a thiazide

HTN
Mild HF
Hypercalcemia

31

What are the less obvious AE for thiazides

Hyperuricemia
Hyperglycemia
Hyperlipidemia

32

Where do aldosterone antagonists act

Collecting tubule

33

How are aldosterone antagonists administered

Orally but with other diuretics

34

When are aldosterone antagonists given

Primary hyperaldosteronism
Edema

35

What is the urine composition in a pt on aldosterone antagonists

Increased Na
Decreased K

36

Which K sparing induce P450

Spironolactone
Epleronone

37

AE in aldosterone antagonists

GI upset, peptic ulcers
Hyperkalemia
Nausea/lethargy
Mental confusion

38

What is ENaC

Na channel

39

Where is ENaC

Collecting duct

40

AE of ENaC inhibitors

Same as spironolactone
Leg cramps
Increase BUN and uric acid

41

What acts in the PT

Acetazolamide

42

How does Acetazolamide work

Prevent H formation for Na reabsorption

43

What is Acetazolamide used for

Glaucoma (reduce aqueous humor)
Mountain sickness prophylaxis
Epilepsy

44

Urine composition in pt on Acetazolamide

Increased Na, K, bicarb

45

How does Acetazolamide affect urine pH

Increases

46

Contraindication for Acetazolamide use

Hepatic cirrhosis

47

Which diuretic does not affect Na excretion

Mannitol

48

When is Mannitol used

Increased ICP
Acute renal failure (shock)
Drug toxicity
Trauma (maintain urine)

49

Which diuretics are IV only

Mannitol
Conivaptan

50

AE of Mannitol

Renal stones
K depletion

51

Where does Conivaptan act

Collecting tubule

52

What is Conivaptan used for

SIADH
Hyponatremia

53

What is the urine composition of someone on Conivaptan

Dilute urine
Decreased Na

54

AE for Conivaptan

Nephrogenic DI
Renal failure