Endogenous Catecholamines and D1 Agonists Flashcards Preview

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Flashcards in Endogenous Catecholamines and D1 Agonists Deck (44)
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1

What binds alpha and beta 2

Epinephrine

2

What binds alpha and beta 1 > 2

Norepinephrine

3

What binds D, alpha and beta

Dopamine

4

What binds D1

Fenoldopam

5

DOC for patients in anaphylactic

Epi

6

Potent vasopressor at high doses

Epi

7

Cause bradycardia

Norepi (indirect M2)

8

Limited therapeutic value, but can treat shock

Norepi

9

DOC for cardiogenic and hypovolemic shock

Dopamine

10

Why is dopamine better than norepi for shock

DA preserves renal blood flow

11

Effects of high dose epi

Increase BP
+ve chronotropic/ionotropic (beta 1)
Vasoconstriction (alpha 1)
Increase CO and O2

12

Effects of low dose epi

Decrease PVR
Increase systolic, decrease diastolic
No change in MAP
Tachycardia (beta 1)

13

SM effects of epi

Bronchodilation (beta 2)
Relax GI with contracted sphincters
Relax detrusor (beta 2), contract sphincter (alpha 1)
Prostate SM contraction

14

Metabolic effects of epi

Hyperglycemia
Lypolysis (beta 3)

15

How does epi cause hyperglycemia

Increase glycogenolysis and glucagon release (beta 2)
Net inhibition of insulin secretion (alpha 2 inhibits, beta 2 enhances)

16

What effect does epi have in glaucoma

Decrease aqueous humor production

17

How do you treat asthma attacks with epi

Combine with local anesthetics to increase duration

18

Causes Vasoconstriction

Epi (alpha 1)
Norepi (alpha 1)

19

Effects of norepi vasoconstriction

Increased PVR
Increased SBP/DBP and MAP

20

Induces hyperglycemia less potent than epi

Norepi

21

Function of DA

Central regulator of movement

22

CVS effects of DA

Low dose - vasodilate (D1): renal, mesenteric, coronary

23

How does DA treat shock

Increase GFR, RBF, Na+ excretion
Ie. preserves renal function

24

What is the inotropic effect of DA

Intermediate contraction (beta 1)
Increasing NE release

25

Effect of DA on BP

Increase SBP

26

Effect of high concentration DA

Alpha 1 vasoconstriction

27

Effect of Fenoldopam

Peripheral vasodilation

28

What is used for short term management of inpatient HTN

Fenoldopam

29

Administration of Epinephrine

IV emergency
SC, ET tube, inhalation, topical eye

30

Why don't you give epi orally

Inactivation in gut