Reduce Clotting Flashcards Preview

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Flashcards in Reduce Clotting Deck (72)
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1

What are platelet aggregation inhibitors used for

Primary Hemostasis

2

What are anticoagulants used for

Secondary Hemostais

3

What are the Platelet Aggregation Inhibitors

Aspirin
Clopidogrel
Ticlopidine
Dipyridamole
Cilostazol
Abciximab
Eptifibatide
Eirofiban

4

What are the Anticoagulants

Heparin
Enoxaparin
Dalteparin
Tinzaparin
Fondaparinux
Leupirudin
Bivalirudin
Argatroban
Warfarin

5

What are Thrombolytics used for

Tertiary Hemostasis

6

What do Thrombolytics activate

Plasmin

7

What are the Thrombolytics

Streptokinase
Urokinase
Alteplase
Reteplase
Tenecteplase
Anistreplase

8

COX inhibitor

Aspirin

9

ADP receptor blockers

Clopidogrem
Ticlopidine

10

PDE inhibitors

Dipyridamole
Cilostazol

11

GPIIb/IIIa blockers

Abciximab
Eptifibatide
Tirofiban

12

Synthetic pentasaccharide

Fondaparinux

13

Direct thrombin inhibitors

Lepirudin
Bivalirudin
Argatroban

14

Coumarin Anti-coagulant

Warfarin

15

Made by beta-hemolytic strep

Streptokinase

16

Recombinant tPA

Alteplase

17

Purified human plasminogen with bacterial streptokinase

Anistreplase

18

Which clotting reducers are irreversible

Aspirin
Clopidogrel
Ticlopidine
Abciximab

19

What does Aspirin do

Block TXA2 - Prolong BT

20

What does TXA2 do

Increase affinity of GPIIb/IIIa for fibrinogen

21

When do you give Aspirin to stop clotting

Cerebral Ischemia
Stroke
MI

22

How long before new COX2 can be synthesized

10 days

23

How do ADP receptor blockers act

Inhibit P2Y12 receptor on platelets

24

When do you use ADP receptor blockers

Recent Stroke, MI, acute coronary syndrome

25

Why do you prefer Clopidogrel over Ticlopidine

Less AE

26

What do you NEVER give with Clopidogrel and why

Omeprazole (inactivates 2C19, 3A4)

27

ADP receptor blockers AE

Inhibit P450
Thrombocytopenic purpura

28

Which ADP receptor blockers can cause neutropenia

Ticlopidine

29

What do you coadminister PDE inhibitors with

Aspirin or warfarin

30

What do PDE inhibitors do

Increase cAMP
Coronary vasodilation