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Flashcards in Pharmacokinetics Deck (9)
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1

P450 Induction

Phenobarbitol
Phenytoin
Rifampin
Carbamazepine

2

P450 Inhibition

Cimetidine
Ketoconazole
Erythromycin
Chloramphenicol

3

Displaced from plasma protein

Warfarin

4

Overdose increases CYP2E1 metabolism

Acetaminophen
N-acetylcysteine

5

Toxic levels of NAPQ1 and reduced GSH

Acetaminophen
N-acetylcysteine

6

Effects of P450 Induction

Increase own metabolism
Increase metab of coadministered drug
Toxic metabolites

7

Effects of P450 Inhibition

Toxic drug concentrations
Prolong active drug presence

8

Adverse effect of warfarin

Bleeding
Reduce absorption (interact with bile acid sequestrant)

9

Adverse effect of Acetaminophen

Liver failure