Pharmacogenomics Flashcards Preview

Pharm Midterm 1 > Pharmacogenomics > Flashcards

Flashcards in Pharmacogenomics Deck (26):
1

Drugs affected by BChE polymorphisms

Succinylcholine

2

Drugs affected by NAT2 polymorphisms

Hydralazine
Procainamide
Isoniazid

3

Drugs affected by 2D6 polymorphisms

Codeine among others

4

Drugs affected by thiopurine S-methyl-transferase polymorphisms

6-MP
Azathioprine

5

Drugs affected by EGFR polymorphisms

Gefitinib

6

Warfarin is affected by which polymorphisms

2C9
VKORC1 (Vit K epoxide reductase)

7

Drugs affected by G6PD deficiency (A-)

Primaquine (sulfonamides)

8

What happens in a BChE polymorphism

AR
Decreased rate of metabolism = longer paralysis

9

What is a normal Dibucaine number

> 75

10

What happens in NAT2 polymorphisms

Slow acetylators = increased drug levels (AR homo)
Fast acetylators = decreased drug levels

11

What happens in 2D6 polymorphisms

Poor = Decreased codeine activation (AR homo)
Ultrarapid = Increased morphine effects (multiple copies)

12

What NAT2 drug can cause lupus

Hydralazine
Procainamide

13

What NAT2 drug can cause neuropathy and hepatotoxicity

Isoniazid

14

AE of poor 2D6

Ineffective dose

15

AE of ultrarapid 2D6

OD leading to resp depression

16

What happens in TPMT polymorphisms

Decreased activity
Only need 1/10 dose of drug

17

What does TPMT do

Catalyses S-methylation of anti-CA thiopurines

18

AE of giving std dose to TPMT polymorphism pt

Myelosupression

19

What happens in EGFR polymorphisms

ATP binding site mutation
Enhances drug effect

20

When is EGFR overexpressed

NSCLC

21

What decreases metabolism of warfarin

2C9 polymorphism

22

AE of 2C9 polymorphism

Increased hemorrhage risk

23

AE of VKORC1 polymorphism

Hemorrhage and thrombosis

24

What happens with a 90-95% reduction in G6PD

Decreased NADPH
Decreased glutathione
Increased H2O2

25

What is G6PD deficiency protective for

Malaria

26

G6PD exacerbation can lead to what

Hemolytic anemia