Indirect Adrenergic Agonists

Question 1

What causes serious vasopressor episodes in pts on MAOIs after release of NE

Answer 1

Tyramine

Question 2

What is the mechanism of Amphetamine

Answer 2

Displace catecholamine from storage vesicle
Weak MAOI
Block catecholamine reuptake

Question 3

Effects of Amphetamine

Answer 3

Increase BP (alpha 1, beta)
Stimulation (alertness, decrease appetite, insomnia)

Question 4

What is Amphetamine used as a Tx for

Answer 4

Depression

Narcolepsy

Question 5

What is the Tx for ADHD in children

Answer 5

Methylphenidate (amphetamine analog)

Question 6

Where is Tyramine found

Answer 6

Cheese

Wine

Question 7

What oxidizes Tyramine

Answer 7

MAO

Question 8

AE of Amphetamine

Answer 8

Fatigue/Depression after stimulation

Question 9

Common feature of all indirect acting adrenergic agonists

Answer 9

Potentiate NE action by causing release