Anemia Flashcards
Used in Oral Fe therapy
Ferrous Sulfate
Ferrous Gluconate
Ferrous Fumarate
Used in Parenteral Fe therapy
Irondextran
Iron Sucrose
Na-Ferric gluconate
What are the Fe chelators
Deferoxamine
Deferasirox
What vitamins are used for anemia treatment
B12 - Cyanocobalamin, Hyroxycobalamin
B9 - Folate
What are the Hematopoetic GFs
Erythropoietin Darbopoietin Filgrastim Sargramostim IL-11
What are the sickle cell agents
Hydroxyurea
What are oral Fe agents used for
Fe deficiency anemia
What are the AE for oral Fe agents
Constipation
Dark stool
Cramps
V/D
When can parenteral Fe agent toxicity occur
Young children by accident
When are parenteral Fe agents given
Oral not tolerated
Cannot be managed by oral alone
What are the AE for parenteral Fe agents
Acute Fe tox
What is seen in Acute Fe toxicity
Necrotizing gastroenteritis with vomitting, pain, bloody diarrhea
Shock, metab acidosis, coma, death
How is Acute Fe toxicity treated
Deferoxamine
When are Fe chelators used
Chronic Fe tox w/o anemia
Hemochromatosis
Multiple transfusions
How do Fe chelators work
Bind absorbed Fe
Promote excretion
What 2 reactions is B12 involved in
Homocysteine to methionine
Methl-malonyl to succinyl
When is B12 given
Loss of IF
Malabsorption
What can be given to partially correct B12 deficiency
B9
What can B12 deficiency cause
Neuro abnormalities (increased homocysteine)
What is B9 needed for
Purine synthesis
What is required to form THF
B12
How long does it take folate deficiency to develop
1-6 months
Drug induced Folate deficiency
MTX
Trimethoprim
Pyrimethamine
B9 AE
Mask neuro deficits in B12 deficiency
