Indirect Cholinergic Agonists

Question 1

Dx for Myasthenia Gravis

Answer 1

Edrophonium

Question 2

Tx for anticholinergic overdose

Answer 2

Physostigmine

Question 3

Reversal of NMJ block by non-depol agents

Answer 3

Neostigmine

Edrophonium

Question 4

Tx of Myasthenia Gravis

Answer 4

Pyridostigmine

Question 5

Reversible AchE/Butylcholinesterase inhibitor

Answer 5

Edrophonium

Question 6

Contraindicated in TCA overdose

Answer 6

Physostigmine

Aggravates cardiac conduction depression

Question 7

Not Liposoluble

Answer 7

Echothiophate

Question 8

Obsolete

Answer 8

Echothiophate

Question 9

QAC

Answer 9

Edrophonium
Neostigmine
Pyridostigmine

Question 10

Carbamate

Answer 10

Physostigmine
Neostigmine
Pyridostigmine

Question 11

Covalent AchE/ButylChE inhibitor

Answer 11

Physostigmine
Neostigmine
Pyridostigmine

Question 12

Does not enter CNS

Answer 12

Neostigmine

Pyridostigmine

Question 13

Organophosphates

Answer 13

Ecthiophate
Malathion
Parathion
Tabun
Sarin
Soman

Question 14

Phosphorylate active site

Answer 14

Ecthiophate
Malathion
Parathion
Tabun
Sarin
Soman

Question 15

Aging to make reversal difficult

Answer 15

Ecthiophate
Malathion
Parathion
Tabun
Sarin
Soman

Question 16

Activated by conversion to O analogs

Answer 16

Malathion

Parathion

Question 17

Nerve agents

Answer 17

Tabun
Sarin
Soman

Question 18

CNS effects of amines

Answer 18

Convulsion
Coma
Resp arrest

Question 19

PS effects of amines

Answer 19

Eye
Resp
GI
UG

Question 20

CVS effects of amines

Answer 20

Decrease CO and BP (hypotension)

Question 21

NMJ effects of amines

Answer 21

Increase contraction in weak muscles

Question 22

Used for intestinal or bladder atony

Answer 22

Physostigmine

Question 23

2nd line Myasthenia Gravis

Answer 23

Neostigmine

Question 24

Prevention and Tx of Urinary retention

Answer 24

Neostigmine

Question 25

Chronic open angle glaucoma

Answer 25

Echothiophate

Question 26

Insecticides

Answer 26

Malathion | Parathion

Question 27

Used for terrorism

Answer 27

Tabun Sarin Soman

Question 28

Used in Alzheimer's

Answer 28

Tacrine Donepezil Rivastigmine Galantamine

Question 29

Orally active

Answer 29

Tacrine Donepezil Rivastigmine Galantamine

Question 30

Only lasts for 2-10min

Answer 30

Edrophonium

Question 31

Spontaneous hydrolysis (30min - 6hrs)

Answer 31

Physostigmine | Neostigmine

Question 32

Fully distributed organophosphates (enter CNS)

Answer 32

``` Malathion Parathion Tabun Sarin Soman ```

Question 33

Tx for organophosphate overdose

Answer 33

Atropine | Pralidoximine

Question 34

CNS toxicity

Answer 34

``` Pyridostigmine Malathion Parathion Tabun Sarin Soman ```

Question 35

AE for Neostigmine

Answer 35

``` N/D Hypotension Salivation Flushing Abdominal pain Bronchospasm ```

Question 36

AE for Physostigmine (high dose)

Answer 36

Convulsions SkM paralysis Bradychardia

Question 37

Action of TCAs

Answer 37

Block Na+ channels

Question 38

Organophosphate poisoning Tx (before aging)

Answer 38

Pralidoxime

Question 39

When is Pralidoxime not used

Answer 39

Carbamate poisoning (reversible, short)

Question 40

Does Pralidoxine enter the CNS

Answer 40

No