Direct Cholinergic Agonists

Question 1

QACs

Answer 1

Acetylcholine
Bethanechol
Carbachol
Methacholine

Question 2

Plant alkaloids

Answer 2

Muscarine
Arecoline
Pilocarpine
Nicotine

Question 3

Bind M only

Answer 3

Bethanechol
Muscarine
Pilocarpine (partial)

Question 4

Bind M and N

Answer 4

Acetylcholine
Carbachol
Methacholine
Arecoline

Question 5

Bind N only

Answer 5

Nicotine (N > M)

Question 6

Activates Bowel and Bladder

Answer 6

Bethanechol

Question 7

Diagnosis of bronchial hyperactivity in asthma

Answer 7

Methacholine

Question 8

Ganglion blocker in high dose

Answer 8

Nicotine

Question 9

Can cause hypotension with rapid, weak pulse

Answer 9

Nicotine

Question 10

No clinical uses

Answer 10

Muscarine

Arecoline

Question 11

PS and S activity on sweat glands

Answer 11

Acetylcholine

Question 12

M3 vasodilation and reflex tachy at low doses

Hypotension and brady at high doses

Answer 12

Acetylcholine

Question 13

Miosis and contraction of ciliaris

Answer 13

Carbachol

Question 14

Ciliaris contraction

Sweat, salivary, lacrimal, bronchial secretion

Answer 14

Pilocarpine

Question 15

Tertiary amines

Answer 15

Pilocarpine

Nicotine

Question 16

N effects of Acetylcholine

Answer 16

Stim autonomic ganglia
Epi secretion from medulla
Skeletal muscle - Increase HR, BP

Question 17

Low dose nicotine effects

Answer 17

Ganglion depol (S + PS)
CVS - sympathomimetic
GI + UG - parasympathomimetic

Question 18

Parasympathomimetic effects of nicotine

Answer 18

N/V/D, voiding, salivation, bronchial secretion

Question 19

High dose effects of nicotine

Answer 19

Ganglion blocker (prolonged depol)

Question 20

Smoking cessation therapy

Answer 20

Nicotine

Question 21

Acute close-angled glaucoma

Answer 21

Pilocarpine

Question 22

Full close angle glaucoma regimen

Answer 22

Pilocarpine
Timolol
Apraclonidine
Acetazolamide
Mannitol or Glycerol

Question 23

Second line for open angle glaucoma

Answer 23

Pilocarpine

1st is timolol

Question 24

2nd line for close angle glaucoma

Answer 24

Carbachol (decrease intraocular pressure)

Question 25

Intraocular surgery

Answer 25

Carbachol

Question 26

Rapid miosis in cataract surgery

Answer 26

Acetylcholine

Question 27

Post surgical, postpartum urinary retention

Answer 27

Bethanechol

Question 28

Hypotonic/atonic, myogenic, neurogenic bladder

Answer 28

Bethanechol

Question 29

Ileus, gastroparesis, congenital megacolon

Answer 29

Bethanechol

Question 30

No CNS effects

Answer 30

Acetylcholine

Question 31

Makes acetate

Answer 31

Acetylcholine

Question 32

Makes Carbamate

Answer 32

Bechanechol | Carbachol

Question 33

Hydrolysis by AchE

Answer 33

Acetylcholine

Question 34

No hydrolysis by AchE

Answer 34

Bethanechol | Carbachol

Question 35

Cannot cross BBB

Answer 35

Bechanechol

Question 36

External use only

Answer 36

Carbachol

Question 37

Slow AchE hydrolysis

Answer 37

Methacholine

Question 38

Crosses placenta

Answer 38

Nicotine

Question 39

Highly liposoluble

Answer 39

Nicotine

Question 40

AE DUMBBELLSS

Answer 40

Acetylcholine Bethanechol Carbachol Methacholine

Question 41

What is muscarinic syndrome

Answer 41

``` Diarrhea   Urination   Miosis   Bradycardia   Bronchoconstriction   Emesis   Lacrimation   Lethargy   Salivation   Sweating   ```

Question 42

CNS disturbances Sweating Salivation

Answer 42

Pilocarpine

Question 43

Effects of acute nicotine poisoning

Answer 43

``` N/V/D Salivation Abdominal pain Cold sweat Confusion ```

Question 44

Death from resp arrest

Answer 44

Nicotine