antiplatelets Flashcards
(25 cards)
What do antiplatelet drugs prevent?
Platelet aggregation → clot formation (especially arterial thrombi).
What conditions are antiplatelets they used for?
MI prevention/post-MI, stroke/TIA prevention, ACS, PCI, intermittent claudication.
What happens if antiplatelets are stopped suddenly?
Increased risk of thrombotic events.
What is the MOA of aspirin?
Inhibits cyclooxygenase → prevents platelet aggregation.
What dose is used for prevention in COX inhibitors?
81 mg (low dose).
What dose is used for acute MI?
325 mg.
What are common AEs of aspirin?
N/V, dyspepsia, hemorrhagic stroke, gastric bleed, prolonged bleeding, tinnitus/hearing loss.
What should patients use to reduce GI effects?
Enteric-coated aspirin.
Is aspirin safe in pregnancy?
Avoid in 3rd trimester.
MOA of P2Y12 ADP inhibitors?
Block P2Y12 ADP receptor on platelets → prevents aggregation.
AEs of P2Y12 inhibitors?
Bleeding, diarrhea, dyspepsia, abdominal pain.
Important precautions for P2Y12 ADP inhibitors?
Avoid during lactation.
Drug interactions of P2Y12 ADP Inhibitors?
CYP450 interactions.
Pre-op instructions for P2Y12 ADP Inhibitors?
Discontinue 5–7 days before elective surgery.
What are Glycoprotein (GP) IIb/IIa inhibitors used for?
Acute Coronary Syndromes, PCI (percutaneous coronary intervention).
Nickname for GP IIb/IIa inhibitors?
“Super aspirin” – most effective antiplatelet.
AEs of GP IIb/IIa inhibitors?
Prolonged bleeding, GI bleed, bleeding from cath site, thrombocytopenia, hypotension, bradycardia.
Nursing for GP IIb/IIa Inhibitors?
Avoid in lactation, CYP450 interactions, D/C 5–7 days before surgery.
Dipyridamole use?
Prevent thromboembolism with heart valve – often with warfarin or ASA.
Cilostazol use?
Intermittent claudication (PAD/PVD).
AEs of arterial vasodilators?
Dyspepsia, N/V.
Nursing for arterial vasodilators?
Avoid in lactation.
What is intermittent claudication?
Cramping/pain in legs, worse with walking.
What’s intermittent claudication a symptom of?
Peripheral vascular disease (PVD).
