ibuprofen-like

Question 1

What is ibuprofen (Advil, Motrin) used for?

Answer 1

Relief of fever, mild to moderate pain, RA, osteoarthritis, myalgia, headache, dental pain, dysmenorrhea

Question 2

What is the mechanism of action for ibuprofen?

Answer 2

Inhibits COX-1 and COX-2, blocking prostaglandin synthesis, and modulates T-cell function

Question 3

What are the common adverse effects of ibuprofen?

Answer 3

Bleeding, anorexia, heartburn, nausea, vomiting, constipation, diarrhea, polyuria, azotemia

Question 4

What are serious adverse effects of ibuprofen?

Answer 4

GI bleeding, hypertension, renal impairment, cardiovascular risk, respiratory function issues in children with asthma

Question 5

What are contraindications for ibuprofen?

Answer 5

Allergy to aspirin/NSAIDs, PUD, GI bleeding, perioperative pain (CABG), hypertension, diabetes, renal/hepatic impairment, heart failure, stroke/MI history

Question 6

What drug interactions should be monitored with ibuprofen?

Answer 6

Oral anticoagulants (increase bleeding), NSAIDs, alcohol, corticosteroids, diuretics, ACE inhibitors, beta blockers, garlic, ginger, feverfew

Question 7

What should be done in case of ibuprofen overdose?

Answer 7

Activated charcoal and nasogastric suction

Question 8

What are the other drugs related to ibuprofen?

Answer 8

Diclofenac, indomethacin, nabumetone, piroxicam, ketorolac (Toradol), etodolac, naproxen, meloxicam

Question 9

What is Celecoxib (Celebrex)?

Answer 9

A second-generation NSAID and COX-2 inhibitor

Question 10

What is the mechanism of action for celecoxib?

Answer 10

Selectively inhibits COX-2, reducing prostaglandin synthesis

Question 11

What are the therapeutic uses for celecoxib?

Answer 11

Osteoarthritis, RA, acute pain, dysmenorrhea, familial adenomatous polyposis

Question 12

What are common adverse effects of celecoxib?

Answer 12

Dyspepsia, abdominal pain, sulfonamide allergy

Question 13

What are serious adverse effects of celecoxib?

Answer 13

MI, stroke, hypertension, edema, renal/hepatic impairment, anemia

Question 14

What are contraindications for celecoxib?

Answer 14

Postoperative CABG phase, GI bleeding/PUD, hypertension, renal impairment, liver disease

Question 15

What drug interactions should be monitored with celecoxib?

Answer 15

Reduced antihypertensive effect of diuretics/ACE inhibitors, increased risk of bleeding with warfarin, hepatic toxicity with other drugs

Question 16

How is a celecoxib overdose managed?

Answer 16

Supportive care, activated charcoal, nasogastric suction

Question 17

What is the mechanism of action of acetaminophen (APAP)?

Answer 17

Inhibits COX centrally and may inhibit chemical mediators of pain, reduces fever by acting on hypothalamus

Question 18

What are the therapeutic uses of acetaminophen?

Answer 18

Analgesic, antipyretic (no anti-inflammatory or antirheumatic action)

Question 19

What are common adverse effects of acetaminophen?

Answer 19

Acute hepatic failure, Stevens-Johnson syndrome (SJS), hepatotoxicity (especially with alcohol)

Question 20

What are serious adverse effects of acetaminophen?

Answer 20

Hepatotoxicity, especially in alcoholics, pancytopenia, leukopenia, nephrotoxicity

Question 21

What are contraindications for acetaminophen?

Answer 21

Hepatic impairment, alcohol use (increased risk of hepatotoxicity)

Question 22

What are drug interactions with acetaminophen?

Answer 22

Warfarin (increased hypoprothrombinemia), echinacea (hepatotoxicity risk)

Question 23

How is an acetaminophen overdose treated?

Answer 23

Within 8-10 hours: Activated charcoal, supportive care, monitor liver function (AST, ALT)

Question 24

What nursing assessments are important for acetaminophen?

Answer 24

Monitor effectiveness, baseline/periodic liver function, signs of hepatotoxicity, alcohol use, kidney function