hyperuricemia + anti-inflam

Question 1

What does allopurinol do?

Answer 1

Inhibits uric acid formation

Question 2

What does febuxostat do?

Answer 2

Inhibits uric acid formation

Question 3

What does probenecid do?

Answer 3

Increases uric acid excretion

Question 4

What does pegloticase do?

Answer 4

Converts uric acid to allantoin for renal excretion

Question 5

What foods should be avoided with hyperuricemia?

Answer 5

Purine-containing foods

Question 6

What are the uses of allopurinol and febuxostat?

Answer 6

Chronic tophaceous gout

Question 7

What are adverse effects of allopurinol and febuxostat?

Answer 7

Hypersensitivity syndrome, GI and neurologic effects, may cause acute gout attack, cataracts (>3 yrs use)

Question 8

What drugs interact with allopurinol/febuxostat?

Answer 8

Warfarin, mercaptopurine, azathioprine, theophylline, ampicillin

Question 9

What are the adverse effects of probenecid?

Answer 9

GI upset (take with food), rash, renal injury

Question 10

What interacts with probenecid?

Answer 10

Aspirin, other salicylates

Question 11

What is Pegloticase (Krystexxa) used for?

Answer 11

IV therapy for chronic gout unresponsive to oral meds

Question 12

What are AEs of Pegloticase?

Answer 12

Gout flare-ups, anaphylaxis, infusion reaction

Question 13

What are the three main NSAID classes?

Answer 13

Salicylates, ibuprofen-like agents, COX-2 inhibitors

Question 14

What is aspirin classified as?

Answer 14

First-generation salicylate

Question 15

What are the indications for aspirin?

Answer 15

Analgesic, antipyretic, anti-inflammatory, antiplatelet, dysmenorrhea, cancer/Alzheimer’s prevention

Question 16

What is the mechanism of action of aspirin?

Answer 16

Inhibits COX enzyme → reduces prostaglandin synthesis

Question 17

What are the GI-related AEs of aspirin?

Answer 17

Stomach pain, heartburn, N/V/D

Question 18

What are serious AEs of aspirin?

Answer 18

Hypersensitivity, GI bleeding, thrombocytopenia, anemia, occult bleeding, nephrotoxicity, hepatotoxicity

Question 19

What are rare AEs of aspirin?

Answer 19

Tinnitus, hearing loss, Reye’s syndrome in children, CHF

Question 20

When is aspirin contraindicated?

Answer 20

Pregnancy (especially 3rd trimester), flu-like illness in children/teens

Question 21

What are aspirin drug interactions?

Answer 21

Anticoagulants, glucocorticoids, alcohol, ibuprofen, ACE inhibitors, ARBs

Question 22

What should be monitored during aspirin use?

Answer 22

Bleeding signs

Question 23

What do ibuprofen-like drugs inhibit?

Answer 23

COX-1 and COX-2 enzymes

Question 24

What are the properties of ibuprofen-like drugs?

Answer 24

Analgesic, anti-inflammatory, antipyretic

Question 25

What is a major GI risk with ibuprofen-like NSAIDs?

Answer 25

GI mucosal damage and bleeding

Question 26

How are most ibuprofen-like NSAIDs processed in the body?

Answer 26

Bound to albumin, metabolized by the liver

Question 27

What toxicity is common with high doses of ibuprofen-like drugs?

Answer 27

Nephrotoxicity