BB Ch 36- Facilities Flashcards Preview

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Flashcards in BB Ch 36- Facilities Deck (100)
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What does the acronym ASHRAE stand for?

American Society for Heating, Refrigeration, and Air Conditioning Engineers


Define biosecurity

All measures taken to detect, prevent, contain, and eradicate adventitious infections


What type of facility is operationally the most efficient

single story centralized facilities with direct access to ground level transportation


What is programming

The decision making phase that defines the scope of the building project. It is often the most challenging and most important part of the facility development process


What is the final product in the programming phase

a program document describing in detail what research will be housed in the facility and its support requirements


Approximately how much space should be set aside for animal facility space when designing a new building with biomedical laboratory space

Approximately 15% of total assignable square footage


Animal housing can be divided programmatically into what four catagories

conventional housing, quarantine, biocontainment, barrier


What is a barrier

A barrier, both physical and operational, is established around the animals to prevent introduction of unwanted adventitious agents that may adversely affect research, or alternatively, may be used to ensure containment when using hazardous agents. Can be established at cage, room, suite, or facility level.


The two commonly room configurations for rack installation is the library configuration and the corridor configuration. Compare and contrast.

Library- more efficient with respect to cage capacity. less productive for servicing since racks must be moved to access.
Corridor- Less efficient with capacity but easier to service since cages can be accessed without moving racks.


What is the most common cubicle size

4 feet deep by 6 feet wide


Describe the configuration of a room floor to the drain in a large animal room

The room floor should be sloped 3/16 inch per foot from a crown in the center of the floor to the floor trough on each side of the room. The bottom of the trough should slope a minimum of 1/4 inch to the foot toward a 6 inch diameter drain with a trap flush.


Describe the ratio of support space to animal housing space

Typically ranges between 30:70 and 70:30. The smaller the facility, the higher the percentage of space devoted to support.


Which two types of containment (hoods) are used for containment of volatile hazardous chemicals or select radioisotopes.

Chemical hoods (personnel protection only) or
Class II Type B2 (100% exhaust BSC) (personnel and product protection)


Disposable cages made of what plastic are useful for highly hazardous chemicals that cannot be easily deactivated?

disposable polystyrene or polyethelene cages


Carcasses with radionuclide have to wait how long before disposal?

Carcasses and waste has to decay for 10 half-lives before disposal into nonradioactive waste streams. Carcasses are held frozen, and caging and bedding are stored until they can be safely processed.


What imaging modality uses radio labeled isotopes?

Positron emission tomography (PET). Positron-emiting radioisotopes such as F18 (T 1/2= 110 min) may require immediate access to cyclotron after administration


What special requirements are needed for MR scanners and why?

Scanner very heavy so require floor with high floor load. Room must be well ventilated to prevent potential for asphyxiation of animals and personnel associated with cryogen boil-off. Require O2 sensor in room.
Require shielding for magnet.


What imaging modalities do not have special requirements/considerations?

CT, SPECT, ultrasound, optical


Outlets in aquatic facilities require what special component?

Should be Ground Fault Interrupted (GFI) or connected to GFI circuit.


Define cleaning

Removal of organic and nonorganic debris adhering to surfaces


Define disinfection

Could be heat or chemical. Reduces but may not eliminate microorganisms for surfaces


Define sanitation

a combination of cleaning and disinfection


Define Sterilization

Eliminates all life forms. Used to indicate a high level of disinfection. Process should be validated on a regular basis.


What temperature is sanitation achieved? Who determined the standard?

National Sanitation Foundation (NSF). Sanitation is achieved at 82.2 C (180F).
Can be achieved at 82.2 C (180F) for 1 sec or
at 71.6 C (161F) for 15 sec or 61.7 C (143F) for 30 min.


What are the two basic types of washers

Cage/rack washer and tunnel washer


What is the temperature range of the autoclave

121-132 C (250-270 F)


What is the single most expensive component of a modern vivarium?

HVAC system


Intake air is filtered with what level of efficiency by the vivarium air handler filters?

85-95% dust spot efficiency


Define HEPA and what is their filtering capability

High Efficiency Particulate Air
99.97% efficient filtering 0.3 um diameter particles
They are more effective capturing particles smaller and larger than 0.3 um.


HEPA filter rely on what 3 mechanisms to achieve their stated efficiency?

interception, impaction, diffusion