Flashcards in BB Ch 36- Facilities Deck (100)
What does the acronym ASHRAE stand for?
American Society for Heating, Refrigeration, and Air Conditioning Engineers
All measures taken to detect, prevent, contain, and eradicate adventitious infections
What type of facility is operationally the most efficient
single story centralized facilities with direct access to ground level transportation
What is programming
The decision making phase that defines the scope of the building project. It is often the most challenging and most important part of the facility development process
What is the final product in the programming phase
a program document describing in detail what research will be housed in the facility and its support requirements
Approximately how much space should be set aside for animal facility space when designing a new building with biomedical laboratory space
Approximately 15% of total assignable square footage
Animal housing can be divided programmatically into what four catagories
conventional housing, quarantine, biocontainment, barrier
What is a barrier
A barrier, both physical and operational, is established around the animals to prevent introduction of unwanted adventitious agents that may adversely affect research, or alternatively, may be used to ensure containment when using hazardous agents. Can be established at cage, room, suite, or facility level.
The two commonly room configurations for rack installation is the library configuration and the corridor configuration. Compare and contrast.
Library- more efficient with respect to cage capacity. less productive for servicing since racks must be moved to access.
Corridor- Less efficient with capacity but easier to service since cages can be accessed without moving racks.
What is the most common cubicle size
4 feet deep by 6 feet wide
Describe the configuration of a room floor to the drain in a large animal room
The room floor should be sloped 3/16 inch per foot from a crown in the center of the floor to the floor trough on each side of the room. The bottom of the trough should slope a minimum of 1/4 inch to the foot toward a 6 inch diameter drain with a trap flush.
Describe the ratio of support space to animal housing space
Typically ranges between 30:70 and 70:30. The smaller the facility, the higher the percentage of space devoted to support.
Which two types of containment (hoods) are used for containment of volatile hazardous chemicals or select radioisotopes.
Chemical hoods (personnel protection only) or
Class II Type B2 (100% exhaust BSC) (personnel and product protection)
Disposable cages made of what plastic are useful for highly hazardous chemicals that cannot be easily deactivated?
disposable polystyrene or polyethelene cages
Carcasses with radionuclide have to wait how long before disposal?
Carcasses and waste has to decay for 10 half-lives before disposal into nonradioactive waste streams. Carcasses are held frozen, and caging and bedding are stored until they can be safely processed.
What imaging modality uses radio labeled isotopes?
Positron emission tomography (PET). Positron-emiting radioisotopes such as F18 (T 1/2= 110 min) may require immediate access to cyclotron after administration
What special requirements are needed for MR scanners and why?
Scanner very heavy so require floor with high floor load. Room must be well ventilated to prevent potential for asphyxiation of animals and personnel associated with cryogen boil-off. Require O2 sensor in room.
Require shielding for magnet.
What imaging modalities do not have special requirements/considerations?
CT, SPECT, ultrasound, optical
Outlets in aquatic facilities require what special component?
Should be Ground Fault Interrupted (GFI) or connected to GFI circuit.
Removal of organic and nonorganic debris adhering to surfaces
Could be heat or chemical. Reduces but may not eliminate microorganisms for surfaces
a combination of cleaning and disinfection
Eliminates all life forms. Used to indicate a high level of disinfection. Process should be validated on a regular basis.
What temperature is sanitation achieved? Who determined the standard?
National Sanitation Foundation (NSF). Sanitation is achieved at 82.2 C (180F).
Can be achieved at 82.2 C (180F) for 1 sec or
at 71.6 C (161F) for 15 sec or 61.7 C (143F) for 30 min.
What are the two basic types of washers
Cage/rack washer and tunnel washer
What is the temperature range of the autoclave
121-132 C (250-270 F)
What is the single most expensive component of a modern vivarium?
Intake air is filtered with what level of efficiency by the vivarium air handler filters?
85-95% dust spot efficiency
Define HEPA and what is their filtering capability
High Efficiency Particulate Air
99.97% efficient filtering 0.3 um diameter particles
They are more effective capturing particles smaller and larger than 0.3 um.