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Flashcards in primary species cram cards Deck (398)
1

rabbit diseases

 

Cryptosporidiosis

Cryptosporidium cuniculus

weanling rabbits most affected

 

2

pig diseases

swine influenza

orthomyxovirus

high morbidity (100%) but low mortality

 

3

pig diseases

 

Things to know about Clostridial enteritis

12hrs-4wks old (peaks at 3 days)

persistent diarrhea, clear fluid with necrotic debris

can die within 4-8 hours after exposure

4

rabbit diseases

 

things to know about Encephalitozoonosis

Encephalitozoon cuniculi

affects multiple species

brain and kidney, granulomas

microsporidian

 

5

in mice the MHC allele is located on what chromosome?

17

6

mouse diseases

 

4 important things about Murine Pneumonia virus

paramyxovirus

co-infection with Pneumocystis common

natural infection is subclinical in immunocompetent mice, dyspnea, listlesness, wasting in immunodeficient

self limiting in immunocompetent, and persistent in immunodeficient

7

rat models

BUF (Buffalo) rat is a model for

spontaneous autoimmune thyroiditis

transplantable Morris hepatoma

8

NHP diseases

things to know about Hepatitis A

Picornaviridae

chimps and cynos and owl monkeys susceptible but no CS

fecal-oral

zoonotic

 

9

rat model

Nude rat is a model for

t cell deficiency

 

autosomal recessive

10

rabbit biology

 

unique characteristics of the urinary system

unipapillate

can separate the tubutles iwth basement membrane intact

ectopic glomeruli are normal

CCMAMP

11

pig diseases

 

things to know about Colibacillosis

caused by pathogenic Escherichia coli

very young- hours old through post weaning

hypersecretory diarrhea

Edema disease 

serious in younger pigs

12

rat diseases

2 things to know about Mycoplasma haemomuris

1- transmitted by Polyplax spinulosa

2) normally latent infection unless activated by immunosuppression or splenectomy

13

mouse diseases

 

name the three flagellated protozoans found in mice

Giardia muris,

Spironucleus muris,

Tritrichomonas muris

14

rat diseases

what Pneumocystis spp infects rats

Pneumocystis cainii

15

pig biology

 

describe the anatomic location of the thyroid and thymus

thyroid and thymus are inverted in their location

16

what stain is used to diagnose amyloidosis

Congo red

17

mouse diseases

 

what is the most common cestode found in mice

Rodentolepis nana or the dwarf tapeworm

 

18

pig biology

 

placentation in swine

diffuse epitheliochorial

19

NHP diseases

things to know about Cercopithecine herpesvirus 2

natural host= African green monkey

AKA Simian agent 8, used as safer antigen for B virus tests

alpha herpes virus, simplex virus

20

NHP diseases

things to know about mollusceum contagiosum

chimpanzees

waxy small tumors on face and extremities

21

NHP diseases

things to know about Streptococcus pneumoniae

in chimps starts as upper respirtory disease

think meningitis

fibrinopurulent leptomeningitis

 

22

list mouse caging material from most expensive to least

polyethermide, polycarbonate, polypropelene, polystyrene, polyethylene

23

which mouse species are resistant to dystrophic mineralization?

C57BL/6

24

mouse diseases

 

3 important things about Rodentolepeis nana

1- direct or indirect lifecycle

2- adults have scolex with 4 suckers and 20-27 rostellar hooks, eggs ahve 6 polar filaments

3- eggs do not survive well outside host

25

pig diseases

 

Things to know about the swine whipworm

Trichuris suis

diarrhea, dehydration

double operculated eggs

2-6mo pigs

 

26

NHP diseases

which pentastomes are found in NW

Porocephalus

27

rabbit diseases

 

things to know about Tyzzers disease

Clostritium piliforme

3-8 wk old rabbits

 

28

mouse diseases

 

6 important things about Helicobacter

1- chronic active hepatitis= H. hepaticus in immune disregulated mice

2- A/J are susceptible, BL6 are resistant

3- silver stain

4- TX by Amoxicillin, Metronidazole, Bismith for 2 weeks

5- other species are H. muridarum, rappini, rodentium, typhlonius, pylori, billus

6- transplacental transmission possible, also recommend foster at less than 24 hours

29

rat model

Gunn rat is a model for 

jaundice

kernicterus 

 

autosomal recessive

30

mouse diseases

 

5 important things about Citrobacter

1. rectal prolapse

2. saphyrophyte

3- DBA,NIH swiss, C57BL are resistant, A/J, C3H are susceptable

4- mucosal hyperplasia of descending colon, pathognomonic

5- causes transmissible colonic hyperplasia

31

NHP biology

common marmosets are more susceptible to which diseases and why?

bacterial

limited MHC class II

32

NHP diseases

things to know about Retroperitoneal fibromatosis associated herpesvirus

gammaherpesvirus, rhadinovirus

immunosuppression with SRV leads to retroperitoneal fibromatosis lesions

33

mouse diseases

 

4 important things about Syphacia

1- 11-15 day life cycle

2- diagnose by tape test

3- eggs are flattened on one side with pointed ends

4- infection is subclinical

34

NHP diseases

what is the most important intestinal parasite in NW NHP

Prosthenorchis elegans

nematode

cockroaches spred

lives in cecum or colon

35

rat model

LOU/C rat is a model for 

myeloma

production of IgG autoantibody

36

rabbit diseases

 

lumbar fracture

L6-L7

37

pig diseases

 

things to know about Balantidium coli

zoonotic

ciliated protozoan

cecum and anterior colon

 

38

mouse diseases

 

5 important things about Giardia muris

1- infects duodenum of young and adult mice

2- does NOT cause diarrhea

3- moves in rolling/tumbling motion

4- elipsoidal cysts with 4 nuclei "monkey face"

5- C3H, SJL, CBA are susceptible while DBA/2, BALB/c and C57BL/6 are resistant

39

what mouse strains have a low natural prevalance of mammary tumors?

BALB/c

C57BL

AKR

40

rat diseases

 

2 things about rotaviruses in rats

most likely human in origin

only see clinical signs of diarrhea up to 12 days old then are resistant

41

rat diseases

 

What rat strain is most susceptible to Nephrocalcinosis

female BDIX rats

42

NHP diseases

things to know about Helicobacter

H. pylori

persistent lymphocytic gastritis

OW and NW

 

43

rat model

WF (wistar furth)

mononuclear cell leukemia

44

which mouse species are susceptible to dystrophic mineralization?

DBA/2 (epicardium)

BALB/c (epicardium)

C3H (myocardium)

45

describe the Bruce effect

strange male pheremones prevent implantation 

46

dog models

which dog breed is a model for Wilson's disease

Bedlington terriers

47

NHP diseases

things to know about Papiine herpesvirus 2

natural host=baboons

used as safter antigen in B virus tests

alpha herpes virus, simplexvirus

48

rat diseases

list 4 things to know about pneumonia virus of mice

paramyxoviridae

no clinical disease signs

wide host range

will burn out if no new susceptibles

49

what does (.) stand for in mouse nomenclature

congenic

50

Animal model

Male pattern baldness

Macaca arctoides

stump tailed macaque

51

Mycoptes musculinus

52

NHP diseases

things to know about Simian Foamy virus

retrovirus, spumavirus

high prevalence

zoonotic, but no clinical signs seen

 

 

53

Pig diseases

things to know about Glassers disease

Haemophilus parasuis

neuro, arthritis, respiratory

3wk-4mo

fibrinous pleuritis

54

describe the difference between the male and female submaxillary salivary gland

males has columnar epithelium with basal nuclei and a larger number of , females have cuboidal epithelium with central nuclei

55

NHP diseases

things to know about Cercopithecine herpesvirus 9

host species= macaques

AKA simian varicellavirus

alphaherpes virus, varicellovirus

56

Lagothrix are animal models for:

cardiovascular research

Hepatitis

Toxoplasmosis

57

which mouse strains have a high natural prevalance of mammary tumors?

C3H 

A

DBA/2

58

mouse diseases

 

pathology of Polyomavirus in mice

induces tumors in mice affected as neonates typically 2-12 months post experimental infection

 

natural infections are asymptomatic

59

Animal model

Hep B and C

Chimps

60

TALEN stands for 

transcription activator like effector nucleases

61

strain specific lesions for A/J

congenital defects such as cleft palate, open eyelids, polydactyly

progressive muscular dystrophy due to dysferlin mutation

systemic amyloidoisis

lung tumors

62

NHP diseases

things to know about Macacine herpesvirus 3

Beta herpesvirus, cytomegalovirus

AKA Rhesus cytomegalovirus

disease only occurs in immunocompromised or with intrauterine infection

"Owl eye" intranuclear inclusions

63

what species has a hemochorial placenta and how may layers does it have?

human, rodents

3

64

mouse models

induction agent for IBD in micee

dextran sodium sulfate (DSS)

65

rat diseases

fow many strains of rat parvoviruses are there and describe the common clinical syndromes

4 of them, Kilham's: Toolan's H-1: rat parvovirus: rat minute virus

pups of persistently infected dams are protected by maternal antibody, infection of non-immune pregnant femals results in persistent infection of pupb

post weanling rats that are exposed develop subclinical infections

66

rat model

Obese SHR

Type 4 hyperlipoproteinemia

 

autosomal recessive

67

rat diseases

list clinical signs of rat theilovirus

immunocompetent rats= no clinical signs

in immunodeficient rats= persistet shedding

68

NHP diseases

things to know about Hepatitis E virus

Hepeviridae

cynos 

 

69

rabbit diseases

 

buphthalmia

autosomal recessive trait with incomplete penetrance

individuals over 3-4 months of age

 

70

animal model

multiple sclerosis/ experimental allergic encephalomyelitis

Callithrix jacchus

intradermal injection of homologous myelin basic protein

71

rabbit diseases

 

things to know about myxoma virus

endemic in sylviagus and fatal in oryctolagus

flat myxomas lesions in skin

fleas and mosquitoes transmit

 

72

mouse diseases

 

what is the most common pin worms in mice

Syphacia obvelata

73

 characteristics of 129 mice

testicular teratomas

74

NHP diseases

what is the only pathogenic ameba in NHP

Entamoeba histolytica

cause flask shaped ulcers

75

NHP diseases

things to know about Campylobacter 

C. jejuni and coli

high prevanlence but often subclinical

infections are self limiting and reinfection is frequent

OW and NW

 

76

pig diseases

 

Things to know about porcine rotavirus

effects 7-28 day old piglets

low mortality

 

77

pig diseases

 

things to know about swine dysentery

Brachyspira hyodysenteriae

malabsorptive mucohemorrhagic diarrhea

seldom apparent in piglets less than 3wks old

 

78

rabbit diseases

 

mandibular prognathism

autosomal recessive trait with incomplete penetrance

maxilla is short relative to mandible

79

rabbit diseases

 

ulcerative pododermatitis

Staph aureus

caging

80

what hormone is responsible for gametogenesis in mice

FSH

81

NHP disease

things to know about Mycobacterium avium-intracellulare

saprophytic

nontuberculoid mycobacteria

causes disease in SIV infected macaques

 

82

rabbit model

induction agent for allergic asthma

ovalbumin in complete freunds adjuvant

83

NHP diseases

things to know about Pasteurella multocida

pneumonia, otitis medi

recent shipping, poor condition animals

84

Myobia musculi

85

rat model

(Lewis) LEW rat is a model for

multiple sclerosis

various experimentally induced autoimmune disease

86

mouse diseases

 

name 5 important facts about the parvo viruses that infect mice

immunosuppressive properties

natural infections are asymptomatic

NS vs VP for differentiation

MPV more persistent than MVM

experimental infection of MVM in neonates results in renal and intestinal hemorrahge and death; experiemntal infection with MPV does not result in any clinical signs, just persistent lymphocytic infection

87

rabbit diseases

 

things to know about Colibacillosis

E. coli strain O15:H and O103:H2 are most virulent strains in european rabbits 4-5 wks of age, high mortality, other strains cause less severe disease

1-2 week old suckling rabbit high mortality

vilous atrophy and fusion in the ileum, cecum and colon

antibiotics not recommended- hemolytic uremic syndrome can develop

 

 

88

Canine diseases

what are the components of the canine infectious respiratory disease complex

Bordatella

Strep equi spp zooepidemicus

Mycoplasma

canine adenovirus type 2

 

89

which animals have two cervices

rat, rabbit, chinchilla, hamster, opossum, woodchuck

90

mouse diseases

 

clinical signs of infection with mamallian orthoreoviruses

severe pantropic infection in infant mice

91

what is unique about the rodent kidney vs most mammals?

it is unipapillate making catheterization easier

vs most mammals which are multipapillate

92

pig models

what breed of pig is a model vor vonWillebrand's disease

Poland China

93

NHP diseases

things to know about Saimiriine herpesvirus 1

natural host= squirrel monkeys

aberent hosts= other new worlds 

alphaherpes virus, simplexvirus

 

94

strain specific lesions for DBA

cardiac calcinosis

glaucoma

 

95

rat diseases

 

cestodes found in rats

Rodentolepis nana

Hypenolepis diminuta

 Taenia taeniaformis

96

NHP diseases

things to know about Orthomyxoviridae

NHPs can serve as experimental model

highly contagious, OW develop upper respiratory clinical signs

97

rabbit diseases

 

rabbit pox virus

rare

fatal

develop blepharitis, conjunctivitis, and keratitis with corneal ulcers, occasionaly rash or skin lesions present

98

mouse diseases

 

name the two reoviruses that infect mice

Mammaliam orthoreoviruses

Group A rotaviruses

99

most common dermatophyte found in mice

Trychphyton mentagrophytes

100

NHP diseases

describe the life cycle of Plasmodium

in host has hepatic phase and erythrocytic phase (known as sporozoites and merozoites leading to production of macro and micro gametocytes)  Gametocytes are taken up by mosquitoes and the sexual phas begins, form oocyst and then sporozoites which are then spread to host by mosquito

101

rat diseases

What neoplasm if the second most common tumor type of F344 rats?

Pituitary adenoma

 

Testicular teratoma is 1st

102

characteristics of C3H/He mice

agouti

blind due to rd1 mutation

corneal opacities

myocardial and skeletal mineralization

age related alopecia

exogenous murine mammary tumor virus

103

strain specific lesions of 129 mice

acidophilic macrophage pneumonia

hyalinosis in other epithelia

megaesophageous

polyarteritis

testicular teratomas

104

animal model

Hemochromatosis

Callithrix jacchus

105

rabbit biology

 

three genus in family leporidae

oryctolagus

lepus

sylvilagus

106

Animal models

toxoplasmosis

Lagothrix- woolly monkey

107

rabbit biology

 

what is unique about the rabbit cardiovascular system

tricuspid valve has 2 cusps

SA node is easy to identify

aortic nerve responds to baroreceptors only, not chemoreceptors

108

rabbit models

of infectious disease

Syphilus

papillomatosis

colibacillosis (RITARD)

Campylobacter (RILT)

109

rabbit biology

 

name the two unsual anatomic features of the intestine of the rabbit

sacculus rotundus (cecil tonsil ( ileum empties into)

fusus coli- distal portion of colon, smaller diameter regulates hard/soft pellet excretion

 

110

NHP diseases

things to know about human herpes virus 1,2

natural hosts= humans

aberent hosts= NW particullarly marmosets

alphaherpes virus, simplexvirus

111

animal model

Gilbert's syndrome

southdown sheep

fasted bolivian squirrel monkeys

112

NHP diseases

which nasal mite is found in NW

Pneumonyssoides

113

pig models

 

which breed of pig is a model for high membranous ventral septal defect?

yucatan

114

define a purified diet

 each nutrient is derived from a specific ingredient

for example, protein from casein or soy, carbohydrate from corn starch or sucrose, fat from lard or corn oil

115

rat diseases

 

rat bladder threadworm

Trichosomoides crassicauda

116

rat diseases

What neoplasm is the most common spontaneous tumor of aged Sprague Dawley and Wistar Han rats?

Pituitary adenoma

Mammary tumors are 2nd

117

pig diseases

Things to know about inclusion body rhinitis

caused by Porcine cytomegalovirus

nursing/newly weaned piglets

growing pigs are exposed to the virus in the environment and produce their own antibodies, causes abortion when pregnant adult animals are exposed for the first time 

118

mouse diseases

 

4 important things about Spironucleus muris

1- infects crypts of Lieberkuhn, duodenum

2- pathogenic for young, stressed or immunocompromised mice

3- age 3-6 weeks most susceptable

4- moves in zig zag motion

119

pig diseases

 

Things to know about sarcoptic mange

Scaroptes scabiei var. suis

acute pruritis

 

120

Radfordia ensifera (rats)

 

121

NHP

humans are most likely to be infected with which species of Plasmodium

vivax, falciparum, 

122

mouse diseases

 

what are the primary differences between MAdV-1 and 2

1 causes fatal multisystemic infection in suckling mice, 2 is typiclaly asymptomatic but is enterotropic in mice less than 3 wks of age

1 causes necrosis of liver, spleen, intranuclear inclusions; 2 causes intranuclear inclusion in mucosal epithelial cells of small intestine

 

123

mouse diseases

 

4 important things about Pseudomonas aeurogenosa

1- clinicall silent in immunologically competent animals, opportunist

2- chronically inhabits nasopharynx, GI tract,

3- dx by clinical signs and history of immunosuppression

4- found in water, acidification to 2.5pH or hyperchloriation to 10 ppm of drinking water

124

Animal model

visceral Leishmania

Chlorocebus aethiops

125

Animal models

model for HIV

baboons and pig tailed macaques will develop disease and immunosuppression with HIV 2 infection

126

which mice species are prone to retinal degeneration?

c3H and CBA

127

what is the most common hematopoietic malignancy

lymphoma 

lymphocytic leukemia originating from the thymus

128

animal model

motion sickness

Saimiri

129

rat diseases

3 important things to know about Pseudomonas aeruginosa

widely distributed in water, soil, sewage

wide host range

rarely see unless immunosuppressed

130

NHP diseases

things to know about Poliovirus

Picornaviridae

Macaques serve as experimental model

typically no CS

if no immune responce can see poliomyelitis and skeletal muscle atrophy

 

131

dog models

which breed is a model for Diabetes mellitus

Keeshond

132

mouse diseases

 

list the common coccidians found in mice

Eimeria falciformis

Klosiella muris

Cryptosporidium muris, parvum

Entamoeba muris

Encephalitozoon cuniculi

Toxoplasma gondii

133

dog models

 

gray collie syndrome

cyclie hematopoiesis

134

use of FVB mice in genetic engineering

microinjection into large pronucleus

135

characteristics of C57BL/6 mice

hydrocephalus

hippocampal neurodegeneration

micropthalmia and anophthalmia

age related cochlear degeneration

malocclusion

pulmonary proteniosis

epithelial hylanosis

late onset amyloidosis

TH1 skewed immune response

136

rabbit diseases

 

things to know about rotavirus infection

yes, rabbits have one too

 

mild diarrhea, mucoid

weaning age most susceptible

 

137

Animal models

 

Leprosy

Cercocebus torguatus atys-  sooty mangaby

Dasypus novempictus- armidillo

138

characteristics of mouse urine

creatinine is excreted instead of creatine
taurine present, tryptophan is absent

139

NHP diseases

things to know about monkey adenovirus

Adeniviridae

respiratory and enteric disease but subclinical infection common

used in research as gene delivery method

in immunocompromised animals=necrotizing pancreatitis

140

pig diseases

 

Things to know about Leptospirosis

caused by Leptospira interrogans- serovars pomona and bratislava

 

 

141

pig management

 

recomendations for vaccination

erysipelas and leptospirosis

 

breeding add Porcine parvovirus, bordatella, pasturella, e coli

142

rat models

Brown Norway (BN) rat is a model for 

inducible, transplantable myeloid leukemia

hydronephrosis

bladder carcinoma

143

rabbit diseases

 

dermatophytosis

trichophyton mentagrophytes

no pruritis

zoonotic

asymptomatic carriers

144

Syphacia obvelata (mice)

 

145

NHP diseases

things to know about Moraxella catarrhalis

epistaxis and mucohemorrhagic discharge

 

146

rat diseases

 

most common pinworm 

Syphacia muris

147

rat diseases

What are the three gastrointestinal bacterial pathogens of rats?

Clostridium piliforme

Salmonella entereditis

Helicobacter

148

rat diseases

 

list the two corona viruses of rats

Parkers rat corona virus

Sialodacryoadenitis virus

149

pig diseases

list the causative agents of atrophic rhinitis

Bordetella bronchiseptica and Pasturella multocida

 

150

Pig diseases

important things to know about Mycoplasmal polyserositis

caused by Mycoplasma hyorhinis

3-10wks

aerosol spred, assoicated with stress

151

NHP diseases

things to know about yellow fever

flaviviridae

asymptomatic in OW, NW are susceptible

mosquitoes

zoonotic

Councilman bodies (eosinophilic inclusions)

Torres bodies (eosinophilic intranuclear inclusions)

152

Animal models

 

natural hosts for SIV

african green, sooty mangabeys, and mandrills 

cause disease (AIDS like) in macaques

153

mouse diseases

 

3 important things to know about K virus

1) tropism for vascular endothelium

2) persistent infection in adults and infants in the renal tubular epithelium

3) intranuclear inclusions in vascular endothelium of small intestine and brain, lung liver

154

canine diseases

zoonotic disease associated with Ancylostoma caninum

cutaneous larval migrans

155

what is the most common ectoparasite in mice

Mycoptes musculinis

156

rat diseases

4 important things to know about Clostridium piliforme

Tyzzers disease

affects numerous species

usually clinically silent, unless recently weaned or immunosuppressed

liver heart GI lesions

157

rat model

COP (Copenhagen) rat is a model for 

prostate adenocarcinoma

158

rabbit diseases

 

proliferative enteropathy

lawsonia intracellularis

weanlings most commonly affected

 

159

pig diseases

Things to know about Swine Enzootic Pneumonia

caused by Mycoplasma hyopneumoniae

3-6 mo old infected (most common in grower and finisher pigs)

central role in porcine respiratory disease complex

 

 

160

NHP diseases

things to know about Tanapox

yabapoxvirinea

host=african green monkey, infects macaques

both intracytoplasmic and intranuclear inclusion bodies

in the epidermis

 

161

pig diseases

 

Things to know about porcine reproductive and respiratory syndrome

arterivirus

clinical signs as name suggests

162

NHP diseases

things to know about Klebsiella pneumoniae

normal flora of upper and lower GI tract

can infect upper respiratory tract and cause disease

pneumonia, air saculitis, septicemia, peritonitis

OW and NW

163

Animal model

Bancroftian filariasis

Presbytis cristatus (silvered leaf monkey)

164

what species do not have a gallbladder

rat, horse, camel, dophin, elephant, pigeon, some hamsters (Chinese and European do not, Siberian and Russian do)

165

mouse diseases

 

4 important things about Aspicularis

1- 23-25 day life cycle

2- diagnose by fecal float

3- eggs are ellipsoidal

4- require 6-7 days incubation to become infective

166

Pig diseases

List 4 diseases that cause arthritis in pigs

Haemophilus parasuis (Glassers disease)

Streptococcus suis

Erysipelas rusiopathiae

Mycoplasma polyserositis

167

Animal model

Hep A and E

Owl, chimps, marmosets

168

describe the Lee Boot effect

estrus supression in group housed females

169

NHP diseases

things to know about Salmonellosis

S. typhimurium, choleraseuis, anatum, stanley, derby, and oranienburg

starts out as GI but can progress to septicemia in neonates, abortion,and pyelonephritis

carrier state can develop, especially if treated with antibiotics

 

170

mouse diseases

 

name the two parvo viruses of mice

minute viruse of mice

mouse parvovirus

171

what CNS ventricular structure does the rat lack

foramen of Magendie

172

mouse diseases

 

4 important things about Staphylococcus

1. aureus is highly pathogenic while epidermidis is nonpathogenic

2. in nude mice, aureus = furunculosis, gland absecesses

3. C57/BL6, C3H, DBA, BALB/c are susceptible

4. suppurative ulcerative and necrotic dermatitis in young mice

173

rabbit diseases

 

things to know about rabbit hemorrhagic disease

calicivirus

3 clinical syndromes: peracute/sudden death

acute/ anorexia, depression, ocular hemorrhage and epistaxis

subacute/ milder and most survive

periportal hepatic necrosis is only consistent microscopic lesion

 

174

what are the primary uses of 129 mice in genetic engineering

source of embryonic stem cells

175

NHP diseases

clincial disease seen with Tritrichomonas mobilensis

diarrhea in squirrel monkeys

176

Animal model

 

Gonorrhea

Pan troglodytes

177

Mouse diseases

 

4 important things about CAR bacillus

1- more significant in rats

2- natural clinical disease is rare

3-silver stain (Warthin-Starry) for diagnosis

4- co pathogen with SV and PVM

178

pig diseases

 

Things to know about Porcine parvovirus

when sows are exposed at <70 days gestation

natural exposure of gilts entering breeding herd leads to development of transferable immunity

 

179

animal model

labor and pelvic organ prolapse

Saimiri

180

rabbit diseases

 

things to know about Psoroptes cuniculi

inner surfaces of external ear

otoacariasis (ear canker)

 

181

Animal models

Malaria

Owl and Squirrel monkeys

182

rabbit models

 

infection with what agent leads to development of hypercalcemic nephropathy?

VX2

183

rabbit diseases

 

things to know about the rabbit pinworm

Passalurus ambiguus

 

perpatent period 56-64 days, eggs are immediately infective

184

animal models

lymphocytic Thyroiditis

Callithrix jacchus

185

rat diseases

4 important things to know about Corynebacterium kutscheri

pseudotuberculosis

multiple randomly distributed abscesses in lungs, liver (rat=lungs)

latent infections in submaxillary lymphnode

disease more frequent in older animals

186

rat diseases

 

clinical disease with reovirus?

No, only seroconvert

187

NHP models

Cercocebus atys

sooty mangaey

AIDS/SIV

leprosy

188

Animal models

Varicella

Erythrocebus patas

Chlorocebus aethiops

189

NHP diseases

things to know about Simian T-lymphotropic virus

retrovirus, deltaretrovirus, type C retrovirus

OW, not NW (Baboons, AG, and macaques)

usually subclinical, latency, develop tumors

 

190

mouse diseases

 

5 important things about Mycoptes musculinis

1- found in the inguinal region, abdomen, back but also on head and neck

2- causes pruritis

3- 8-14 day life cycle

4- feed on superficial epidermis

5- heavily chitinized, "boxing gloves" on last two legs

191

NHP models

Chlorocebus

grivet, vervet

infectious diesease- yellow fever, plague, leprosy, hepatitis legionnaires disease, varicella

192

rat biology

 

which hormonal reproductive effects are seen in rats

Lee Boot effect (minimally). no Bruce or Whitten

193

NHP diseases

things to know about Molineus elegans

small intestine of NW (particullarly capuchin and squirrel)

nematode

 

194

animal models

stress

Saimiri (naturally high cortisol levels)

195

Callithrix are animal models for:

Parkinson's disease

Multiple sclerosis

Hemochromatosis

 

196

rat model

F-344 is a model for 

toxicology

inbred by NAtional Toxicology Program

197

rat diseases

 

which strains are most susceptible to chronic progressive nephropathy?

F344

Sprague Dawley

198

how many toes does the mouse have on each foot

5 on front and 5 on back

199

mouse diseases

 

important things to know about LDHV (lactate dehydrogenase elevating virus)

Arteriviridae

asymptomatic, disease requires immunosuppression

transmitted via infected biologicals

LDH can be 5-20x normal

C58, AKR develop paralytic syndrome which is age dependent

passage through rats eliminates from biologicals

200

NHP diseases

things to know about Macacine herpesvirus 5

ADA rhesus rhadinovirus

gammaherpesvirus, rhadinovirus

lymphadenopathy

SIV immune mediated anemia

201

rabbit diseases

 

things to know about papillomavirus infections

cottontail (shope) papillomavirus

 

horny warts,

cottontail rabbits are natural host

arthropod spread

oncogenic (squamous cell carcinomas)

used to study oncogenic virus biology

202

NHP diseases

name the 2 trematodes found in NHP

Gastrodiscoides hominis

Schistosoma spp

 

203

NHP diseases

things to know about Mycobacterium Leprae

chronic granulomatous disease affecting the skin and peripheral nerves with lesions preferentially occuring in cooler areas

sooty mangaby (Cercocebus atys)

and chimpanzees

 

204

rabbit diseases

 

intestinal coccidiosis

Eimeria

post weanling rabbits most likely to experience mortality

suckling rabbits are considered resistant

vaccine sprayed into nest box when rabbits are 25 days of age

 

 

205

rabbit diseases

 

things to know about hydrocephalus

single autosomal recessive 

 

hypovitaminosis A

206

NHP diseases

which species of Plasmodium are NW NHP most likely to be infected with?

simium, brazilianum

207

pig biology

 

what is unique about the pig lymphnode?

it is inverted, with germinal centers located in the internal portion of the node

 

similar to elephant, rhino, dolphin, hippo, and warthog

208

Animal model

 

toxemia of pregnancy

Erythrocebus patas

209

animal models

 

Strabismus

saimiri

210

NHP diseases

things to know about Encephalomyocarditis virus

Picornaviridae

rodents are carriers

baboons

usually found dead

211

NHP diseases

most susceptible NHP to Giardia

macaque with SIV

212

describe the changes that occur in the adrenal glands in mice

X-zone between medulla and cortex in immature males and young virgin females

213

Canine diseases

which serovars of Leptospirosis are dogs most commonly infected with?

Grippotyphosa, pomona, Bratislava 

214

215

Canine diseases

things to know about Canine herpes virus

turkey egg kidneys

rapidly fatal disease in puppies

216

rat diseases

3 things about hantavirus

bunyviridae

rodents are natural reservoir

infections are chronic and subclinical

217

which species have an epitheliochorial placenta and how many layers does it have 

cow, pig, horse

 

6 layers

218

rabbit diseases

 

list the three pox viruses found in rabbits

myxoma virus

rabbit (shope) fibroma virus

rabbit pox virus

219

Aspicularis tetraptera

220

Which mouse strains are most susceptible to amyloidosis?

A and SJL

221

orbital sinus vs plexus

mice have sinus rats have plexus

222

Canine diseases

list the most common roundworm of dogs

Toxascaris canis

 

Toxascaris leonina

223

pig diseases

 

Which organisms are responsible for coccidiosis in pigs?

Eimeria

Cryptosporidium parvum

Isospora suis

 

5-10 days Or suckling and recently weaned pigs

mild disease

224

rabbit diseases

 

which gamma herpes viruses have been isolated from cottontail rabbits

1 and 3

225

rat diseases

What is the most important disease of aging rats

chronic progressive nephropathy

226

rabbit diseases

 

splay leg

simple autosomal recessive inheritance

unable to adduct typically hindlimbs

 

227

NHP  diseases

things to know about Lawsonia intracellularis

proliferative enteritis

 

228

NHP diseases

list the 2 cestodes (tapeworms) found in NHP

Spargana

Echinococcus

229

which mouse strain has a high incidence of thymic lymphoma from murine leukemia retrovirus

AKR

230

Animal model

Parkinson's Disease

Callithrix jacchus

MPTP

231

rat diseases

4 things to know about Clostridium piliforme

1. Tyzzer's disease

2. rats less commonly affected that mice

3. peracetic acid is prefered disinfectant

4. intestine, liver heart in rats (mice no heart)

 

232

NHP diseases

which nasal mite is found in OW NHP

Pneumonyssus

233

pig diseases

 

things to know about pig lice

Haematopinus suis

sucking lice

pruritis

234

what does / stand for in mouse nomenclature

substrain

235

mouse diseases

 

4 important things about Myobia musculi

1- 23 day life cycle

2- cause of hypersensitivity

3- one empoidial claw

4- found on head, neck, and shoulder regions

236

NHP diseases

things to know about Nocardia spp

saprophytes

multinodular areas of consolidation of pulmonary lesions

look like coccidiomycoides or TB

237

rabbit diseases

 

Clostridium difficile

affect ileum and jejunum instead of cecum

I

238

NHP diseases

things to know about Kyasanur Forest Disease

flavivirus

Bonnet macaques are model

ixodid ticks spred

 

239

rat model

Brattleboro rat is a model for 

diabetes insipidus (autosomal recessive)

240

NHP diseases

things to know about Histoplasma capsulatum

think baboons and skin touching the ground

241

rat diseases

three things to know about Salmonella enterica

clinical signs are rare and unspecific

hepatitis with white spots

culture on selenite broth, brilliant green or MacConkey agar

242

define a chemically defined diet

formulated with very basically defined ingredients, ie specific animo acids, sugars, triglycerides, and essential fatty acids

243

rat models

BB/Wor is a model for

juvenille insulin dependent diabetes mellitus

244

NHP diseases

things to know about yatapox

yabapoxviridea

macaques and baboons

zoonotic

SQ masses

 

245

mouse diseases

 

list the two herpes viruses that infect mice

mouse cytomegalovirus (Beta herpes)

mouse thymic necrosis virus

246

rabbit biology

 

describe the rabbit estrous cycle

they do not have one, induced ovulator

247

rabbit diseases

 

things to know about Enterotoxemia

caused by Clostridium spiroforme (primary pathogen)

young rabbits/change in gut flora

 

248

pig models

 

name the two primary uses for swine

surgical models

xenotransplantation

249

NHP diseases

things to know about simian parvirus

parvoviridae

erythrocytic tropism

potential zoonosis

fulminant hepatitis and rheumatoid arthritis

 

250

Radfordia affinis (mice)

251

characteristics of FVB mice

blind due to homozygosity at rd1 allele

prone to seizures

prone to persistent mammary hyperplasia

252

rat diseases

 

5 things to remember about CAR bacillus

1. overt disease is uncommon

2. wide host range

3. clinical signs and gross lesions are indistinguishable from Mycoplasma

4. silver stain

5. forms large bronchial abscesses

 

253

Pig diseases

 

Things to know about Erysipelas rhusiopathiae

diamond skin disease

3mo-3ys of age (growing or adult)

acute=septicemia and death

chronic= enlarged stiff joints, diamond shaped lesions

carriers are source, shed in feces

zoonotic

 

 

254

255

describe the Witten effect

estrous induced by introduction of male pheremones

256

NHP diseases

things to know about Shigella

S. flexneri, boydii, sonnei

both OW and NW

think diarrhea and gingivitis (also abortion and air sac infection)

large intestine

culture on three successive days

257

rabbit models

induction agent for model of inflammatory bown disease

dinitrochlorobenzene (DNCB)

258

consomic

chromosome substitution

259

rabbit diseases

 

things to know about malignant lymphoma

tetrad of lesions, kidneys-splemonegaly- lymphadenopathy

 

260

rat biology

 

estrous cycle of the rat

4-5 days

continuously polyestrous

261

NHP diseases

things to know about rotaviruses

reoviridae

self limiting watery diarrhea

 

262

rat diseases

What is the suspected cause of auricular chonritis?

immune mediated reaction to Type II collagen

263

animal model

Spongiform Encephalopathy

Saimiri

264

rat diseases

3 things to know about Corynebacterium kutscheri

1. in rats most commonly affects lungs (multisystemic in mice)

2. can cause persistent asymptomatic infections

3. methenamine silver stain

265

rat diseases

What are the 6 bacterial respiratory pathogens?

Streptococcus pneumoniae

Corynebacterium kutcheri

CAR

Mycoplasma pulmonis

Pasturella pneumotropica

Streptobacillus moniliformis

266

uses of C57BL/6 in genetic engineering

most often used background strain

267

rabbit biology

 

name the salivary gland that does not have a human counterpart

zygomatic

268

strain specific lesions of BALB/c

epicardial mineralization and cardiomyopathy

imperforate vagina and mucometra

B cell lymphoma/reticulum cell sarcoma

mammary adenocarcinoma

269

Rat biology

 

What is the name of the gland found in the rostral nasal cavity of the rat that contributes to maintenance of mucous blanket covering the ciliated respiratory surfaces

Steno's gland

 

seems to be unique to the rat

270

NHP models

Erythrocebus patas

Patas monkeys

pregnancy toxemia

271

rat diseases

 

which rat strain is most susceptible to myocardial degeneration/fibrosis

aged Sprague Dawley

272

mouse diseases

 

4 important things about Clostridium piliforme

1. Tyzzers disease

2. C57CL/6 resistant, DBA, CBA susceptible

3. environmental decontamination difficult

4 trifecta of clinical signs (GI, heart, liver) heart rare in mice

5. pickup sticks on silver stain

273

rabbit diseases

 

scarptes scabiei

pruritic

burrowing mite

 

274

rat diseases

 

Which rat strain is most prone to testicular neoplasms

F344

275

NHP disesases

things to know about macacine herpes virus 1

AKA B virus

alpha herpes virus, simplexvirus

natural host=macaque

aberent host= humans

 

276

rat diseases

2 things to know about Sendai virus in rats

1. paramyxovirus

2. asymptomatic and self limiting in rats, unlike in mice

 

277

what species have an endotheliochorial placenta and how many layers does it have 

dog, cat

4

278

rat model

ACI rat is a model for

congenital genitourinary anomalies

 

prostatic adenocarcinoma

279

rat diseases

Which rat strain is most susceptible to polyarteritis nodosa

SHR

280

rat biology

 

significance of left azygous vein in pigs

drains intercostal vessels into coronary sinus

different from other mammals where it enters the precava

281

mouse diseases

 

6 important things to know about LCMV

Arenaviridae

4 biotypes (1. late disease 2. cerebral 3. mortality/neonatal runting 4. viscerotropic)

non-cytolytic/ minimally pathogenic but experimental intracerebral injection can cause disease

ZOONOTIC

think hamsters for amplification

 prototype for T lymphocyte mediated immune injury

282

NHP diseases

things to know about Hepatitis B virus

Hepadnaviridae

Chimps

 

283

NHP diseases

things to know about monkeypox

orthopox

papules leading to vesicular rash, pock lesions (including hands and feet)

intracytoplasmic inclusion bodies

 

284

rabbit diseases

 

things to know about Pastureloosis

head tilt

snuffles

weanlings

suppurative inflammation

use SPF rabbits

285

NHP diseases

things to know about Rhesus papillomavirus

Papillomaviridae

hyperplasiaof stratum spinosum and corneum with spontaneous resolution

 

286

mouse diseases

 

what are 3 important things about mouse herpes viruses

1) natural infections are asymptomatic, no matter the strain

2) persist in the salivary glands

3) pathology of cytomegalovirus is megalocytes with eosinophilic intranuclear inclusions in cervical salivary glands.  pathology of mouse thymic cirus is thymic necrosis with intranuclear herpetic inclusions

287

pig diseases

 

Things to know about Pleuropneumonia

Actinobacillus pleuropneumoniae

less than 6mo, peak mortality 10-16 weeks

severe pleuropneumoniae, sudden onset, high mortality and high morbidity

can become chronic or carrier forms

288

rat diseases

 

list 3 things you should know about Streptococcus pneumoniae

1. usually asymptomatic

2. fibrinopericarditis, fibrinopleuritis are classic lesions

3. Optochin test (zone of growth inhibition on blood agar plates)

and Neufeld-Quellung reaction- swelling of capsule 

 

289

characteristics of BALB/c

males pugilistic

dystrophic epicaridal mineralization

auricular thrombosis

corneal opacities

resistant to spontaneous amyloidoisis

TH2 skewed immune response

290

rabbit diseases

 

list the three gamma herpes viruses of rabbits

leporid herpesvirus 1,2,3

 

291

rat biology

 

describe the biology of the salivary glands in rats

parotid- serous

submaxillary/submandibular= mixed

sublingual= mucous

292

mouse diseases

 

4 important things about Sendai virus

paramyxovirus

no persistent state in immunocompetent mice

C57 highly resistant; DBA/2 are susceptable

bronchial and interstitial pneumonia

293

Saguinus are animal models for:

Viral hepatitis

colonic adenocarcinoma

IBD

294

pig diseases

 

THings to know about Transmissible Gastroenteritis

Coronavirus

all ages, <2wks severe signs

diarrhea and vomiting

 

295

Polypax serrata is found in what species of rodents and is the vector for what blood borne parasite

mouse, Mycoplasma coccoides

296

CrISPR stands for 

clustered interspaced short palindromic repeats

297

rabbit diseases

 

which gamma herpes viruses cause disease

leporid herpesvirus 3, lymphoproliferative disease with lymphoid infiltration of many organs

298

mouse diseases

 

what organisms are known for causing white spots on the mouse liver

Corynebacterium

Yersiniosis

Salmonellosis

Tyzzers

Ecromelia

Reovirus

MHV

Pasturella

Helicobacter

299

NHP diseases

NHP most likely to be infected with Cryptosporidium spp

immunosuppressed macaques

300

canine diseases

what is the hookworm found in dogs?

Ancylostoma caninum

 

Ancylostoma braziliense

301

mouse diseases

 

4 things about Encephalitozoon cuniculi

1- think rabbits and brain/neuro and kidney

2- no clinical signs in mice

3- microsporidian

4- stain with either Giemsa or Goodpasture 

302

NHP diseases

things to know about Macacine herpesvirus 4

AKA Rhesus lymphocryptovirus

gammaherpesvirus, lymphocryptovirus

natural host= ?

aberent host= Rhesus

coinfection with SIV leads to lymphoma or lesions resembling oral hairy leukoplakia

 

303

mouse diseases

 

identify the two papovaviruses that infect mice

Polyomavirus and K virus (Kilham virus)

304

what does (c) stand for in mouse nomenclature

recombinant congenic

305

list mouse caging material from most durrable to least

polyethylene, polystyrene, polypropylene, polycarbonate, polyethermide

306

pig diseases

 

Things to know about Porcine circovirus associated disease

Type 2

 

Post weaning multisystemic wasting syndrome, porcine dermatitis and nephropathy syndrome, porcine respiratory disease complex and occasionally repro failures

307

NHP diseases

things to know about Bordatella bronchiseptica

commensal in nasopharynx

respiratory disease

308

in what species is proteinuria normal

rats and dogs

309

Pig diseases

 

Things to know about Pasteurellosis

severe suppurative bronchopneumonia

primary= septicemia in piglets

secondary= in conjunction with other diseases and stress

 

310

mouse diseases

 

3 important things about Pasturella pneumotropica

1- subclinical opportunistic pathogen, if immunosuppressed will see clinial signs

2- suppurative inflammation and abscesses

3- ubiquitous inhabitant of skin, upper respiratory tract and GI

311

rat diseases

 

what is the most common mite?

description?

Radfordia ensifera

two claws EQUAL length

312

what does (;) stand for in mouse nomenclature

incipient congenic

313

mouse diseases

 

8 important things about Salmonella

1. serovars Typimurium and Enteritids

2. Zoonotic

3. nutritional iron deficiency has attenuating effect

4. BL6, C3H are susceptible, AJ, CBA are intermediate, 129 are resistant

5. 3 types of infection seen acute in young mice; subactue mice have distended abdomens with hepatomegally and splenomegally, chronic mice have weight loss and anorexia

6. granulomatous lesions leading to septic thrombi

7. enrich with Selenite F cystine broth before culture

8. subclinical carriers and chronic carriers are seen when animals recover

314

NHP diseases

CS seen with Sarcocystist kortei or nesbitti

monkey is intermediate host (get from eating raw monkey)

think white nodules in mesentery and serosa, no inflammatory reaction

315

NHP diseases

things to know about Yersina

Y. enterocolitica and pseudotuberculosis

fulminating enteric and septicemic disease 

NW and OW

Squirrel monkeys=cervical lymph nodes enlarged

will also see vomiting and severe abdominal pain

316

pig biology

 

hormone to detect pregnancy

esterone sulfate, peak at 23-30 days gestation, produced by fetus

317

rabbit diseases

 

things to know about alpha herpesvirus infection 

leproid herpesvirus 4

from domestic rabbits 

severe disease in preweanlings

 

318

pig biology

 

which breeds are susceptible to malignant hyperthermia

Duroc, Yorkshire, Poland China, Landrace, Pietran

 

 

damn you poor little piggy

319

NHP diseases

things to know about the measles virus

Paramyxoviridae, morbillivirus

Rhesus monkey is model for measles infection

Koplik's spots

respiratory and derm signs, NW get GI 

causes immunosuppression

 

320

NHP diseases

things to know about Saimiriine herpesvirus 2

natural host= squirrel monkey

aberent host= other new worlds, owl monkeys

lymphoma, lymphocytic leukemia (model for Burketts lymphoma)

gammaherpesvirus, lymphocryptovirus

related to Epstein-Barr virus/infectious mononucleosis

 

321

rabbit diseases

 

hepatic coccidiosis

Eimeria stiedae

younger, more cysts

multifocal yellowish white lesions of varying size and white streaks on liver

bile and gallbladder also

 

322

NHP diseases

things to know about Rabies virus

rhabdoviridae, lyssavirus

vaccinate, attenuated vaccines are bad-can produce disease in NW

 

 

323

rat diseases

3 things to know about M. pulmonis

1. natural host for M. pulmonis

2. persistent life long infection

3. single most important historical infectious complication of research

324

rabbit diseases

 

most common tumor in rabbits

uterine adenocarcinoma

325

mouse diseases

 

5 important things about Mousepox virus

1) 3 forms of disease  asymptomatic, chronic, acute lethal

2) liver, spleen and epithelial cell lesions with inclusions are pathognomonic

3) Marchal bodies (type A intracytoplasmic inclusions) acidiphilic well demarcated incusion bodies in epuithelial cells. Type B are basophilic and found in internal organs

4) DBA/1, DBA/2, BALB/c, A, C3H are most susceptible

C57BL6, AKR are most resistant

5) orthopox virus

 

326

NHP diseases

things to know about Simian virus 40

polyomavirus

common latent infection but clinical disease associated with immunosuppression

brain, lung, kidney lesions, 

327

what hormone is responsible for secreation of androgens

LH

328

rat diseases

3 things about rat cytomegalovirus

Beta herpesvirus

low significance as no known natural infections

latency in salivary glands

329

pig models

 

which breed is a model for melanoma

Sinclair

330

conplastic

mitochondiral substitution

331

mouse diseases

5 important things to know about mouse hepatitis virus

1) corona virus

2) 2 strains- enterotropic and neurotropic/respiratory/ multisystemic

infects suckling mice less than 2 wks of age

3) necrosis and syncytia of either intestinal villi or nasal mucosa or multiple organs

4) persistent infection of immunocompromised mice

5) SJL and A/J mice are resistant; BALB/c and DBA/2 are susceptible

332

NHP diseases

things to know about Nochia nochi

stomach, pouches that look like cauliflower

nematode

333

NHP diseases

things to know about Simian Hemorrhagic Fever Virus

arteriviridae

Patas, AG, and baboons are reservoir

Macaques fata bleeding syndrome

hemorrage and necrosis of proximal duodenum (not hepatic or adrenal)

 

334

rat diseases

Which strain is most prone to mammary neoplasms?

Sprague Dawley

F344 and Wistar Han are second

335

Animal models

Colonic adenocarcinoma,

ulcerative colitis/IBD

Sagunius oedipus

336

NHP diseases

things to know about Simian Immunodeficiency virus

retrovirus, lentivirus

low pathogenicity in African, disease in Asian

zoonotic

persistent lymphadenopathy, tropism for CD4 T cells

 

337

rule of thumb for salivary gland products

parotid= serous

submaxillary= mixed (serous in mice)

sublingual= mucous

338

pig diseases

 

List the common respiratory diseases of swine

mycoplasmal pneumonia

atrophic rhinitis

pasteurellosis

inclusion body rhinitis

pleuropneumonia

Swine flu

pseudorabies (Aujeszky's disease)

 

339

NHP diseases

things to know about the Filoviruses

Ebola and Marburg

Marburg= from AG monkeys

adrenal and hepatic necrosis

 

340

rabbit models

mutation seen in Watanabe Heritable Hyperlipidemic Rabbit

LDL receptor deficent

341

Pig diseases

 

Important things to know about Streptococcus suis

5-16 wk old most susceptible (nursing or recently weaned pigs)

Meningitis, arthritis 

zoonotic

fibrinous bronchitis, pleuritis, pericarditis

342

rabbit biology

 

unique characteristics of reproductive tract

duplex uterus with separate cervices

inguinal pouches located lateral to genetilia in both sexes

inguinal canals are open in males

343

NHP diseases

things to know about Colibacillosis

frequent normal fecal isolate but may or may not cause clinical disease

EPEC is common pathogen of SIV infected macaques

NW and OW

344

what does (x) stand for in mouse nomenclature

recombinant inbred

345

animal model

Legionnaires Disease

Cavia procellus

Callithrix jacchus

Chlorocebus aethiops

Macaca mulatta

346

canine diseases

zoonotic disease associated with Toxascaris canis

 

visceral larval migrans and ocular larval migrans

347

rabbit models

induction agent for acute acalculous cholecystits

lysophosphatidylcholine

348

pig biology

 

describe the important facets of pig coronary anatomy

right sided dominant and no pre-existing collateral circulation

349

NHP biology

tamarins are more susceptible to which diseases and why?

viral 

limited MHC class I

350

mouse diseases

 

4 important things about Corynebacterium

1. pseudotuberculosis- liquifactive caseous material

2. bovis- orthokeratotic hyperkeratosis, scaly skin

3. "chinese letters"

4. differential for low humidity.

351

pig diseases

 

Things to know about greasy pig disease

Staph hyicus

5days-2mo 

no pruritis

 

352

mouse diseases

 

identify the two adenoviruses of mice

MAdV-1 and 2  or A and B

353

mouse diseases

 

What is the principal intermediate host for Toxoplasma gondii?  The definitive host?

mouse

 

cat

354

Animal models

Diabetes mellitus

Macaca nigra

355

mouse diseases

 

2 important things about Radfordia affinis

1- causes little to no inflammatory reaction

2- two empodial claws of unequal length

356

mouse diseases

 

4 important things about Theilers murine encephalomyelitis virus

1) mouse polio virus, Cardiovirus

2) experimentally induced neurologic disease, demyelinating phase, paralysis, some recovery

3) replicates in intestinal mucosa

4) SJL, DBA/2, C3H are susceptable; BALB/c, B6, 129 are resistant

357

Animal models

 

chronic destructive periodontitis

Oryzomys palustris- rice rat

Callithrix jacchus- common marmoset

358

Saimiri are animal models for:

pharmacology/toxicology

neuroscience

CJD

malaria

labor and pelvic organ prolapse

359

Canine diseases

which protozoal diseases are associated with immunosuppression

Isospora

360

Which mouse strains are resistant to amyloidosis?

C57BL, BALB/c and C3H

 

361

strain specific lesions for C3H

dystrophic cardicac calcinosis

hamartomas

mammary tumors

 

362

pig diseases

importatnt things to know about Pseudorabies

Aujeszky's disease

herpes virus

latent in sensory ganglia

high mortality in pigs under 9 weeks of age

reportable disease

 

363

rat diseases

 

the rat louse has what name and is the vector for what hemoplasma

Polyplax spinulosa

Mycoplasma haemomuris

 

364

NHP diseases

things to know about Dengue Hemorrhagic Fever

flavivirus

macaques are asymptomatic

mosquito transmits

zoonotoic

365

pig diseases

 

Things to know about Proliferative Ileitis/enteritis

caused by Lawsonia intracellularis

pigs 6-20 wks infected

hyperplasia of crypt enterocytes

wide host range

silver stain

 

366

NHP diseases

things to know about Anatrichosoma spp

think white lines on hands and feet

nematode

 

367

rabbit model

heratibility of the WHHL model?

autosomal dominant

368

rat diseases

 

What anesthetic agent is known to cause adynamic illeus

Cloral hydrate

369

NHP diseases

most common nematode in OW and great apes

Oseophagostomum

370

NHP models

Pan troglodytes

AIDS

HEP B,C

cognition and language development

371

describe the difference between male and female mouse kidneys

cuboidal epithelium lining Bowman's capsule in males, squamous epithelium in females

372

Aotus are animal models for:

malaria

cutaneous and visceral leishmaniasis

viral hepatitis A

vision

373

rabbit biology

 

what is unique about the alkaline phosphatase of rabbits

they have three isoforms (liver , intestinal and kidney.  other mammals have 2 intensinal and liver/kidney/rest)

374

NHP diseases

things to know about Pneumocystis

species specific

ubiquitous in the environment

associated with SIV or other immunodeficiency

 

375

pig diseases

 

things to know about Salmonellolsis

S. choleraesuis, typhimurium, typhisuis

3wks-5m old

respiratory, enteric, and repro systems

 

376

rat diseases

describe the clincial syndromes seen with sialodacryoadenitis virus

corona virus

breeding colonies, mature rats are immune, clinical disease is associated with preweanling animals enzootic 

in epizootic, post weanling to adult rats are exposed and develop cervical swelling due to infallmmation and edema of submaxillary glands

in immunodeficient rats, see persistent infection

377

rabbit diseases

 

Treponematosis

Treponema paraluiscunniculi (similar to T. pallidum)

rabbit syphylis

spirochetes with Warthin starry silver stain

tests:  RPR rapid plasma reagin card test or veneral disease research laboratory slide test

 

378

rat biology

 

transfer of antibodies from mom to pup occurs when?

in utero via the yolk sac

intestinal absorption of colostrum for up to 16 days postpartum

379

NHP disease

name the sucking louse found in NHP

Pediculus

380

rat biology

hearing range of rat

500Hz to 60-80kHz

381

rat model

Zucker rat is a model for 

obesity

382

383

rat model

SHR (spontaneous hypertensive rat) is a model for

hypertension

cardiovascular research

384

what does : stand for in mouse nomenclature

outbred

385

rabbit diseases

 

things to know about rabbit (shope) fibroma virus

fibramatosis endemic in wild rabbits

spread by arthropods

fibromas are flat, subcutaneous, eaisly moveable tumors

 

386

rat diseases

3 things to know about Streptobacillus moniliformis

1. causative agent of rat bite fever

2. commensal of nasopharynx of wild rats

3. does not cause disease in rats

387

Mouse diseases

 

7 important things about Mycoplasmosis

1- chattering

2- rats are reservoir for mice

3- C57BL6 resistant; BALB/c, C3H, DBA/2 are susceptible

4- treatment only suppresses disease

5- T cell response exacerbate clinical signs

6- cobble stone appearance of lungs

7- nude/SCID mice develop systemic disease

388

rat diseases

 

What rat strains have a high prevalence of hydronephrosis?

Brown Norway

Gunn

Zucker

389

rabbit diseases

 

things to know about coronavirus

pleural effusion disease

congestive heart failure

390

NHP diseases

which pentastomes are found in OW

armillifer and porocephalus

391

NHP diseases

Simian Retrovirus (SRV)

retrovirus, betaretrovirus, type D

zoonotic

CS= generalized lymphadenopathy, retroperitoneal fibromatosis when infected with gamma herpesvirus

broad immune cell tropism

 

392

animal models

cutaneous leishmania

Aotus

Saguinus

393

mouse diseases

 

name the two paramyxoviruses that infect mice

Sendai

Murine pneumonia virus 

394

animal models

Crohn's disease

terminal ileitis in Saguinus mystax and labiatus

395

rabbit models

difference between WHHL and St Thomas rabbits

St Thomas have normal LDL receptors

396

pig diseases

 

List the common enteric diseases

swine dysentery

proliferative Ileitis

Colibacillosis

Clostridial enteritis

transmissible gastroenteritis

rotaviral enteritis

 

397

rat diseases

 

Which rat strain is most susceptible to Alveolar histiocytosis?

F344 and Sprague Dawley

398

mouse diseases

 

4 important things to know about Group A rotaviruses (murine rotavirus)

EDIM

high morbidity, low mortality

affects mice less than 2 wks of age

terminally differentiated enterocytes, vacuolation at the tips