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Flashcards in mouse coat color Deck (30)
1

pheomelanin is responsible for what color granules?

yellow/red

2

eumelanin is responsible for what color granules?

black/prown

3

Myo5a is responsible for what part of color production?

transport of melanin to keratinocytes

4

Tyrosinase is responsible for what part of color production?

converstion of tyrosine to melanin which leads to pigment formation

5

what gene encodes for Tyrosinase

Tyr

6

which genes control migration of melanocytes

Kitl, Kit, Ednrb

7

what disease is associated with piebald coat color?

megacolon

8

what disease is associated with dominant white?

congenital anemia, pups die within a few days after birth

9

what disease is associated with brindle color?

males die within 10-14 days, those that live and are homozygous females have slight tremors and uncoordinated gait

10

what disease is associated with homozygous dominant yellow coat color?

die on sixth day of gestation

11

what disease is associated with albino coat color?

blindness

12

what are the 5 genes responsible for the most common coat color vatiations in mice?

nonagouti
brown
albino
dilution
pink-eyed dilution

13

what chromosome is the nonagouti locus found on

Chr 2

14

what chromosome is the brown locus found on?

Chr 4

15

what chromosome is the albino locus found on?

Chr 7

16

What chromosome is the dilution locus found on?

Chr 9

17

What chromosome is the pink-eyed dilution found on?

Chr 7

18

which is the most polymorphic of the coat color loci?

the nonagouti

19

what is the new name for the B or b (black vs brown) locus

Tyrp

20

what is the new name for the C or c (pigmented vs albino) locus

Tyr

21

what is the new name for the D or d locus (non-dilute vs dilute)

Myo5a

22

what is the other name for the pink-eyed dilution locus

Oca (for oculocutaneous albinism) eumelanin content of the melanin granules in mice that are homozygous for the Oca locus is greatly diminished resulting in pink eyes and dilute coat color

23

what chromosome is the Kit locus located?

Chr 5

24

what phenotype is a mutation at the Kit locus responsible for?

black eyed white (white spotting loci)

25

the piebald mutation is caused by a mutation in the ____________ locus on Chr _________.

Ednrb, Chr 14

26

mutation at which locus results in the beige coat color. What chromosme is it located on?

Lyst, 13

27

what is the genotype of the coat color for a BALB/c

AbcD (A Tyrp1+ Tyr c, Myo5a+) aka albino

28

what is the genotype of the coat color for a C3H?

ABCD (A Tyrp1+ Tyr+ Myo5a+) aka black agouti

29

what is the genotype of the coat color for a C57BL/6?

aBCD (a Tyrp1+ Tyr+ Myo5a+) aka black non-agouti

30

what is the genotypoe of the coat color for a DBA

abCd (a Tyrp1b Tyr+ Myo5a d) aka dilute brown non-agouti