Flashcards in mouse coat color Deck (30)
1
pheomelanin is responsible for what color granules?
yellow/red
2
eumelanin is responsible for what color granules?
black/prown
3
Myo5a is responsible for what part of color production?
transport of melanin to keratinocytes
4
Tyrosinase is responsible for what part of color production?
converstion of tyrosine to melanin which leads to pigment formation
5
what gene encodes for Tyrosinase
Tyr
6
which genes control migration of melanocytes
Kitl, Kit, Ednrb
7
what disease is associated with piebald coat color?
megacolon
8
what disease is associated with dominant white?
congenital anemia, pups die within a few days after birth
9
what disease is associated with brindle color?
males die within 10-14 days, those that live and are homozygous females have slight tremors and uncoordinated gait
10
what disease is associated with homozygous dominant yellow coat color?
die on sixth day of gestation
11
what disease is associated with albino coat color?
blindness
12
what are the 5 genes responsible for the most common coat color vatiations in mice?
nonagouti
brown
albino
dilution
pink-eyed dilution
13
what chromosome is the nonagouti locus found on
Chr 2
14
what chromosome is the brown locus found on?
Chr 4
15
what chromosome is the albino locus found on?
Chr 7
16
What chromosome is the dilution locus found on?
Chr 9
17
What chromosome is the pink-eyed dilution found on?
Chr 7
18
which is the most polymorphic of the coat color loci?
the nonagouti
19
what is the new name for the B or b (black vs brown) locus
Tyrp
20
what is the new name for the C or c (pigmented vs albino) locus
Tyr
21
what is the new name for the D or d locus (non-dilute vs dilute)
Myo5a
22
what is the other name for the pink-eyed dilution locus
Oca (for oculocutaneous albinism) eumelanin content of the melanin granules in mice that are homozygous for the Oca locus is greatly diminished resulting in pink eyes and dilute coat color
23
what chromosome is the Kit locus located?
Chr 5
24
what phenotype is a mutation at the Kit locus responsible for?
black eyed white (white spotting loci)
25
the piebald mutation is caused by a mutation in the ____________ locus on Chr _________.
Ednrb, Chr 14
26
mutation at which locus results in the beige coat color. What chromosme is it located on?
Lyst, 13
27
what is the genotype of the coat color for a BALB/c
AbcD (A Tyrp1+ Tyr c, Myo5a+) aka albino
28
what is the genotype of the coat color for a C3H?
ABCD (A Tyrp1+ Tyr+ Myo5a+) aka black agouti
29
what is the genotype of the coat color for a C57BL/6?
aBCD (a Tyrp1+ Tyr+ Myo5a+) aka black non-agouti
30