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Flashcards in misc cards Deck (90)
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1
Q

list some rat eplipsy models

A

1) GAERS rat: genetic absence eplipesy rat
2) GEPR 3 and 9 rats, genetically epilepsy prone rat 9 more severe than 3
3) WAG/Rij

2
Q

immunodeficiency viruses are in what family?

A

lentiviruses

3
Q

what are anabolic steroids classified as by the DEA?

A

class III

4
Q

who must qualify researchers and approve protocols using Schedule 1 substances?

A

the FDA

5
Q

how long should records be retained for a GLP study that was submitted to the FDA

A

2 years following approval or 5 years following submisstion

6
Q

how long should records be retained for a GLP study that was not submitted to the FDA?

A

2 years from the date the study was completed, discontinued or terminated

7
Q

what does CITES stand for

A

convention on international trade in endangered species of wild fauna and flora

8
Q

CITES appendix I classification description

A

species threatened with extinction

9
Q

CITES appendix II classification description

A

species not necessarily threatened with extinction, but in which trade must be controlled in order to avoid utilization incompatible with their survival

10
Q

CITES appendix III classification description

A

species that are protected in at least one country

11
Q

what is required to acquire a CITES appendix 1 animal

A

import and export permits

12
Q

what is required to acquire a CITES appendix 2 animal?

A

export permit

13
Q

what is required to acquire a CITES appendix 3 animal from a protected country?

A

export permit

14
Q

what is required to acquire a CITES appendix 3 animal from a non-protected country?

A

certificate of origin

15
Q

what form is required to register with the DEA

A

Form 224

16
Q

what form is required to order schedule 1-2 controlled substances?

A

Form 222

17
Q

how long must physical records pertaining to controlled substances be retained?

A

2 years

18
Q

how often must inventories of controlled substances be performed?

A

every 2 years

19
Q

what must a controlled substance inventory contain

A
date on which inventory was conducted,
names of the controlled substances,
dosage units and types
number of dosage units
number of commercial containers
record of disposition
20
Q

define schedule 1 controlled substances

A

have a high potential for abuse, have no currently accepted medical use, lack of accepted safety for use of the drug or other substance under medical supervision

21
Q

define schedule 2 controlled substances

A

high potential for abuse which may lead to severe psychological or physical dependence

22
Q

define schedule 3 controlled substances

A

potential for abuse less than substances in schedules 1 and II and abuse may lead to moderate or low physical dependence or high psychological dependence

23
Q

define schedule 4 controlled substances

A

low potential for abuse and may lead to limited physical dependence or psychological dependence

24
Q

define schedule 5 controlled substances

A

low potential for abuse and consist primarialy of preparations containing limited quantities of certain narcotics

25
Q

pentabarbital is what schedule

A

II, (III if has phenytoin)

26
Q

morphine is what schedule

A

II

27
Q

medatomidine is what schedule

A

not controlled

28
Q

midazolam is what schedule

A

IV

29
Q

thiopental is what schedule?

A

III

30
Q

oxymorphone is what schedule?

A

II

31
Q

diazepam is what schedule?

A

IV

32
Q

Telazol is what schedule?

A

III

33
Q

Fentanyl is what schedule?

A

II

34
Q

Butorphanol is what schedule?

A

IV

35
Q

ketamine is what schedule?

A

III

36
Q

phenobarbital is what schedule?

A

IV

37
Q

buprenorphine is what schedule?

A

III

38
Q

xylaxine is what schedule?

A

not controlled

39
Q

anabolic steroids are what schedule?

A

III

40
Q

chloral hydrate is what schedule?

A

IV

41
Q

list some nonhuman primates that are CITES appedix 1

A

all great and lesser apes, Macaca silensus, Callithrix flaviceps, Saguinus bicolor, S. leacopus, S. oedipus. Saimiri oerstedti

42
Q

how are narcotic substances regulated

A

by CFR title 21 part 1300 controlled substance act, administered by the secretary of health and human services adn enforced by the DEA

43
Q

what is the agency responsible for importation of all animals/animal products that include animals or products that could pose a disease threat to US livestock, infectious organisms and vectors, cell cultures and recombinant products?

A

USDA, APHIS

44
Q

what is the document for transportation regulations?

A

CFR49 title 9, chapter 1

45
Q

what animals require USDA permits for import

A

swine, ruminants, other hoof stock, poultry/birds

46
Q

which small lab animals require USDA permits?

A

animals that have been inoculated/exposed to infectious agents. trangenic animals that are specifically made to allow for productive infection with human pathogens.

47
Q

which agency controls import of non human primates?

A

us public health service through the CDC, office of health and safety

48
Q

how often must importers register with the CDC?

A

every 2 years

49
Q

who is responsible for regulations pertaining to importing animals that may be infectious to humans?

A

PHS, US dept of health and human services

50
Q

who is responsible for enforcement of regulations regarding transport of endangered species

A

US fish and wildlife service, department of the interior

51
Q

what does the Lacey Act cover?

A

transportation, importation, exportation, sale or purchase of any fish, wildlife or plants that may harm humans or US horticulture, forestry or wildlife resources

52
Q

what is the governing ordnance for GLP work?

A

CFR title 21 part 58

53
Q

irradiation dose for standard rodent feed

A

25 kGy

54
Q

irradiation dose for gnotobiotic rodent feed

A

50 kGy

55
Q

effect of UV-A black light

A

320-400nm. pigmentation of skin

56
Q

effect of UV-B light

A

280-320nm, photokeratitis, cataracts

57
Q

effect of UV-C light

A

100-280nm, germicidal effects

58
Q

define class I laser

A

no hazardous radiation

59
Q

define Class II laser

A

not enough power to injure someone accidentally, can cause injury if viewed for extended period of time

60
Q

define Class IIIa laser

A

can cause injury if viewed with binoculars

61
Q

define Class IIIb laser

A

can cause injury if viewed directly

62
Q

define Clads IV laser

A

can start fires

63
Q

major rat allergen

A

Rat n1, urinary

64
Q

major mouse allergen

A

Mouse ml, urinary males secrete more than females

65
Q

major cat allergen

A

Fel d1, saliva, skin, hair

66
Q

major dog allergen

A

Can f1. saliva, hair skin

67
Q

major guinea pig allergen

A

urine is major allergen, also dander and saliva

68
Q

major rabbit allergen

A

fur is major allergen, saliva and urine are minor

69
Q

major bird allergen

A

IgG mediated hypersensivity pneumonitis

70
Q

describe Splendoe Hoeppli phenomenon, what type of granules are associated with it?

A

results from Ag-Ab reaction and concurrent accumulation and incorporation of cellular debris, “Botryoid” granules- sulfur granules that stain thick refractive eosinophilic material arranged in a stellate radiating or asteroid manner

71
Q

what is the trichrome stain used for?

A

collagen and muscle fiber

72
Q

what is the Oil Red O or Sudan Black stain used for?

A

lipids

73
Q

what is the congo red stain used for?

A

amyloid, bi-refringent with polarized light

74
Q

what is the cresyl violet stain used for?

A

cell bodies of neurons

75
Q

what is the luxon fast blue stain used for?

A

myelin

76
Q

what is the alizarin red stain used for?

A

calcium (bone)

77
Q

what is the prussian blue stain used for?

A

hemosiderin

78
Q

what is the Alcian blue stain used for?

A

mucins (cartilage)

79
Q

what is the PAS stain used for?

A

polysaccharides, cell wall

80
Q

properties of thiopental?

A

ultra short acting barbiturate

81
Q

what are the properties of Inactin/Thiobutabarbital?

A

long acting in rats, good for maintaining renal perfusion
bad in rabbits
barbituate

82
Q

What are the properties of alpha chloralose

A

long acting
preserves respiratory and cardiovascular reflexes
poor induction and recovery

83
Q

what are the properties of Avertin/ tribromoethanol

A

used in GEM’s
can cause inflammation and peritonitis
unreliable plane of anesthesia

84
Q

action of benzodiazepines on GABA?

A

enhance the affinity of the receptors for GABA

85
Q

action of barbiturates on GABA?

A

decrease the rate of dissociation of GABA from its receptor

86
Q

what are the properties of chloral hydrate?

A

schedule IV controlled substance
sedative and hypnotic agent
causes adynamic ileus
medium duration, light anesthesia with minimal effects on cardiovascular system

87
Q

what are the properties of urethane?

A

carcinogenic
long acting
minimal reflex depression

88
Q

give examples of the denaturants

A

Quaternary ammonium compounds
phenolics
alcohols

89
Q

give examples of the reactants

A

aldehydes

ethylene oxide

90
Q

give examples of oxidants

A

halogens (chlorine bleach, chlorine dioxide)

Peroxygens (vaporized hydrogen peroxide, Virkon)