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Flashcards in misc cards Deck (90)
1

list some rat eplipsy models

1) GAERS rat: genetic absence eplipesy rat
2) GEPR 3 and 9 rats, genetically epilepsy prone rat 9 more severe than 3
3) WAG/Rij

2

immunodeficiency viruses are in what family?

lentiviruses

3

what are anabolic steroids classified as by the DEA?

class III

4

who must qualify researchers and approve protocols using Schedule 1 substances?

the FDA

5

how long should records be retained for a GLP study that was submitted to the FDA

2 years following approval or 5 years following submisstion

6

how long should records be retained for a GLP study that was not submitted to the FDA?

2 years from the date the study was completed, discontinued or terminated

7

what does CITES stand for

convention on international trade in endangered species of wild fauna and flora

8

CITES appendix I classification description

species threatened with extinction

9

CITES appendix II classification description

species not necessarily threatened with extinction, but in which trade must be controlled in order to avoid utilization incompatible with their survival

10

CITES appendix III classification description

species that are protected in at least one country

11

what is required to acquire a CITES appendix 1 animal

import and export permits

12

what is required to acquire a CITES appendix 2 animal?

export permit

13

what is required to acquire a CITES appendix 3 animal from a protected country?

export permit

14

what is required to acquire a CITES appendix 3 animal from a non-protected country?

certificate of origin

15

what form is required to register with the DEA

Form 224

16

what form is required to order schedule 1-2 controlled substances?

Form 222

17

how long must physical records pertaining to controlled substances be retained?

2 years

18

how often must inventories of controlled substances be performed?

every 2 years

19

what must a controlled substance inventory contain

date on which inventory was conducted,
names of the controlled substances,
dosage units and types
number of dosage units
number of commercial containers
record of disposition

20

define schedule 1 controlled substances

have a high potential for abuse, have no currently accepted medical use, lack of accepted safety for use of the drug or other substance under medical supervision

21

define schedule 2 controlled substances

high potential for abuse which may lead to severe psychological or physical dependence

22

define schedule 3 controlled substances

potential for abuse less than substances in schedules 1 and II and abuse may lead to moderate or low physical dependence or high psychological dependence

23

define schedule 4 controlled substances

low potential for abuse and may lead to limited physical dependence or psychological dependence

24

define schedule 5 controlled substances

low potential for abuse and consist primarialy of preparations containing limited quantities of certain narcotics

25

pentabarbital is what schedule

II, (III if has phenytoin)

26

morphine is what schedule

II

27

medatomidine is what schedule

not controlled

28

midazolam is what schedule

IV

29

thiopental is what schedule?

III

30

oxymorphone is what schedule?

II

31

diazepam is what schedule?

IV

32

Telazol is what schedule?

III

33

Fentanyl is what schedule?

II

34

Butorphanol is what schedule?

IV

35

ketamine is what schedule?

III

36

phenobarbital is what schedule?

IV

37

buprenorphine is what schedule?

III

38

xylaxine is what schedule?

not controlled

39

anabolic steroids are what schedule?

III

40

chloral hydrate is what schedule?

IV

41

list some nonhuman primates that are CITES appedix 1

all great and lesser apes, Macaca silensus, Callithrix flaviceps, Saguinus bicolor, S. leacopus, S. oedipus. Saimiri oerstedti

42

how are narcotic substances regulated

by CFR title 21 part 1300 controlled substance act, administered by the secretary of health and human services adn enforced by the DEA

43

what is the agency responsible for importation of all animals/animal products that include animals or products that could pose a disease threat to US livestock, infectious organisms and vectors, cell cultures and recombinant products?

USDA, APHIS

44

what is the document for transportation regulations?

CFR49 title 9, chapter 1

45

what animals require USDA permits for import

swine, ruminants, other hoof stock, poultry/birds

46

which small lab animals require USDA permits?

animals that have been inoculated/exposed to infectious agents. trangenic animals that are specifically made to allow for productive infection with human pathogens.

47

which agency controls import of non human primates?

us public health service through the CDC, office of health and safety

48

how often must importers register with the CDC?

every 2 years

49

who is responsible for regulations pertaining to importing animals that may be infectious to humans?

PHS, US dept of health and human services

50

who is responsible for enforcement of regulations regarding transport of endangered species

US fish and wildlife service, department of the interior

51

what does the Lacey Act cover?

transportation, importation, exportation, sale or purchase of any fish, wildlife or plants that may harm humans or US horticulture, forestry or wildlife resources

52

what is the governing ordnance for GLP work?

CFR title 21 part 58

53

irradiation dose for standard rodent feed

25 kGy

54

irradiation dose for gnotobiotic rodent feed

50 kGy

55

effect of UV-A black light

320-400nm. pigmentation of skin

56

effect of UV-B light

280-320nm, photokeratitis, cataracts

57

effect of UV-C light

100-280nm, germicidal effects

58

define class I laser

no hazardous radiation

59

define Class II laser

not enough power to injure someone accidentally, can cause injury if viewed for extended period of time

60

define Class IIIa laser

can cause injury if viewed with binoculars

61

define Class IIIb laser

can cause injury if viewed directly

62

define Clads IV laser

can start fires

63

major rat allergen

Rat n1, urinary

64

major mouse allergen

Mouse ml, urinary males secrete more than females

65

major cat allergen

Fel d1, saliva, skin, hair

66

major dog allergen

Can f1. saliva, hair skin

67

major guinea pig allergen

urine is major allergen, also dander and saliva

68

major rabbit allergen

fur is major allergen, saliva and urine are minor

69

major bird allergen

IgG mediated hypersensivity pneumonitis

70

describe Splendoe Hoeppli phenomenon, what type of granules are associated with it?

results from Ag-Ab reaction and concurrent accumulation and incorporation of cellular debris, "Botryoid" granules- sulfur granules that stain thick refractive eosinophilic material arranged in a stellate radiating or asteroid manner

71

what is the trichrome stain used for?

collagen and muscle fiber

72

what is the Oil Red O or Sudan Black stain used for?

lipids

73

what is the congo red stain used for?

amyloid, bi-refringent with polarized light

74

what is the cresyl violet stain used for?

cell bodies of neurons

75

what is the luxon fast blue stain used for?

myelin

76

what is the alizarin red stain used for?

calcium (bone)

77

what is the prussian blue stain used for?

hemosiderin

78

what is the Alcian blue stain used for?

mucins (cartilage)

79

what is the PAS stain used for?

polysaccharides, cell wall

80

properties of thiopental?

ultra short acting barbiturate

81

what are the properties of Inactin/Thiobutabarbital?

long acting in rats, good for maintaining renal perfusion
bad in rabbits
barbituate

82

What are the properties of alpha chloralose

long acting
preserves respiratory and cardiovascular reflexes
poor induction and recovery

83

what are the properties of Avertin/ tribromoethanol

used in GEM's
can cause inflammation and peritonitis
unreliable plane of anesthesia

84

action of benzodiazepines on GABA?

enhance the affinity of the receptors for GABA

85

action of barbiturates on GABA?

decrease the rate of dissociation of GABA from its receptor

86

what are the properties of chloral hydrate?

schedule IV controlled substance
sedative and hypnotic agent
causes adynamic ileus
medium duration, light anesthesia with minimal effects on cardiovascular system

87

what are the properties of urethane?

carcinogenic
long acting
minimal reflex depression

88

give examples of the denaturants

Quaternary ammonium compounds
phenolics
alcohols

89

give examples of the reactants

aldehydes
ethylene oxide

90

give examples of oxidants

halogens (chlorine bleach, chlorine dioxide)
Peroxygens (vaporized hydrogen peroxide, Virkon)