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Flashcards in hamster Deck (151)
1

Syrian Hamster

Mesocricetus auratus

2

Chinese Hamster

Cricetulus griseus

3

Armenian Hamster

Cricetulus migratorius

4

European Hamster

Cricetus cricetus

5

Djungarian (Russian Dwarf) Hamster

Phodopus campbelli

6

Siberian Dwarf Hamster

Phodopus sungorus

7

suborder for hamsters?

Myomorpha

8

anatomical characteristics

large cheek pouches, thick bodies, short tails, excess loose skin, only incisiors erupt continuously

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Native environment and behavior

arid, temperate regions, live deep in tunnels where cooler and more humid. Diurnal activity in wild

10

activity in laboratory environment

nocturnal

11

origin of Syrian hamster

originated from one litter captured in Syria in 1930

12

Carcinogenesis model

1) cheek pouch carcinogenesis oral tumor formation
2) pancreatic ductal adenocarcinoma: nitrosamine
3) SV40: oncogenic virus
4) Human adenovirus: potential cancer therapeutic
5) exogenous estrogen to males leads to renal tumors

13

Metabolic disease models

1) cholesterol cholelithiasis: excess dietary cholesterol or sucrose-rich diet
2) diabetes mellitus: STZ or alloxan
3) Atherosclerosis through dietary manipulation

14

Cardiovascular models

1) cardiomyopathy (DCM and HCM) sarcoglycan gene (dystrophin complex)

15

Infectious disease models

1) Leishmania
2) Hantavirus
3) SARS
4) prions

16

Gestation length in syrian hamster

15-18 days

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Weaning

21 days

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Puberty

M 6-8w
F 8-12w

19

characteristics of the cheek pouch

extensively microvascular
immune privilaged

20

unique characteristics of respiratory system

develop centrilobular emphysema when exposed to intratracheal porcine pancreatic elastase- model for COPD

21

sexual dimorphism of hardarian gland

females secreate 10^3 more porforin

22

diet for hamsters

standard rodent diets

23

T/F Placement of the food on the floor is not allowed for Hamsters.

False: IT IS allowed

24

fluid requirements

8.5ml/100g (Low when compared to other species, linked to natural adaptations for water conservation)

25

Name two unique pharmacological responses seen in hamsters

more sensitive to metabolic effects of corticosteroids
less senstive to effects of morphine

26

length of estrous cycle

4 days

27

best time to mate hamsters

third day after postovulatory discharge, copious creamy white opaque viscous discharge

28

pregnancy determination

abdominal distention around 10 days post breeding, absence of postovulatory discharge 5-9 days post breeding (normal estrous cycles)

29

when does the estrous cycle resume following parturition?

1-8 days

30

hamster weighing 60g or less needs how much space

10in^2

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hamster weiging over 60g needs how much space

13-19in^2

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female hamster with litter needs how much space

121in^2

33

height of all hamster cages

6in

34

examples of hamster enrichment

nesting material

35

recommended temperature for hamsters

68-79F

36

light cycle recommendations

non breeding 12-14h light

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causative agent for proliferative enteritis

Lawsonia intracellularis

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description of Lawsonia intracellularis

gram negative nonspore forming, slightly curved rod, obligate intracellular bacterium

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clinical signs of proliferative enteritis

watery diarrhea, moist, matted fur on the tail, perineum and ventral abdomen

40

morbidity and mortality for proliferative enteritis

high for both

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transmission of proliferative enteritis

fecal-oral

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clinical signs of acute proliferative enteritis

hemorrhagic diarrhea

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clinical signs of sub-acute proliferative enteritis

delayed growth and diarrhea

44

clinical signs of chronic proliferative enteritis

no clinical signs

45

gross findings of proliferative enteritis

segmental thickening and congestion of the ileum, enlargement of mesenteric lymph nodes

46

histopathologic findings of proliferative enteritis

hyperplasia of columnar mucosal epithelial cells in the terminal ileum

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identification of Lawsonia intracellularis

Warthin starry stain

48

susceptible ages of hamsters to proliferative enteritis

weanlings most susceptable

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detection of lawsonia intracellularis

fecal PCR

50

treatment of lawsonia intracellularis

supportive care

51

control of lawsonia intracellularis

depopulation, facility sanitation, repopulation with uninfected hamsters

52

causative agent of tyzzers disease

Clostridium piliforme

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description of colostridium piliforme

spore forming intracellular bacterium

54

transmission of tyzzers disease

fecal oral of spores

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control of Tyzzers disease

improved sanitation and isolation

56

clinical signs of Tyzzers disease

roughened hair coat, diarrhea, and high mortality (young or immunosuppred animals only)

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necropsy findings with Tyzzers disease

enterocolitis, lymphadenitis, multifocal necrotizing hepatitis

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diagnosis of Tyzzers disease

special staining of tissues (Giemsa, silver stain)

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Clinical signs of clostridium difficile

profuse , watery, hemorrhagic diarrhea

60

histiologic findings of clostridium difficile

typhilitis and colitis in adult hamsters

61

risk factors for clostridium difficile overgrowth

antibiotic administration, change in diet

62

control of outbreak of clostridium difficile

depopulation, decontamination, (chlorine dioxide) and repopulation

63

histology of salmonella infection

septic thrombi

64

control of salmonella infection

well managed facilities

65

description of helicobacter

gram negative curved to spiral fusiform morphology

66

2nd most common hamster disease

pneumonia/ Pasturella pneumotropica, Streptococcus pneumoniae, and other Streptococcus diseases

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species of helicobacter found in hamsters

H. cinadei, H. mesocricetorum, H. cholecystus, H. aurati,

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clinical signs have only been associated with which species of Helicobacter

H. aurati, gastritis, chronic and progressive typhlocolitis, intestinal metaplasia, dysplastic lesions in large intestine

69

which hamster viruses should be part of routine screening?

1) LCMV
2)Hamster parvovirus
3) Murine pneumonia virus
4) Reovirus
5) Sendai virus

70

most likely species to transmit LCMV to humans?

hamsters

71

primary reserviour for LCMV?

mouse

72

description of LCMV

RNA virus, arenavirus

73

clinical signs of LCMV

natural infection generally causes acute short term infection. perinatally exposed animals remain subclincal. Congenitally or neonatal animals remain persistently infected and may develop chronic, progressive fatal disease

74

most likely route of infection by LCMV for hamsters?

implantation of tumors infected

75

necropsy findings of LCMV

lymphocytic infiltration of the liver, lungs, pancreas, kidney, spleen, meninges, and brain

76

route of transmission for LCMV

excreted in the urine, contanct

77

what is the ABSL level for LCMV

BSL3, zoonotic

78

description of Sendi virus

single stranded RNA virus Paramyoviridae family

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natural host for Sendai virus

mice

80

clinical signs of Sendai virus

mortality in newborn pups, most infections are subclinical

81

route of transmission for Sendai virus

direct contact with infected rodents

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necropsy findings of Sendai virus

hyperplasia of nasal mucosal epithelium, hyperplasia of bronchial epithelium, peribronchial edema

83

do hamsters have their own species specific adenovirus?

No, but can be infected with adenoviruses from a variety of other species, most typically the murine adenovirus

84

animals most susceptable to adenovirus infection?

immunocompromised

85

clincial signs of adenovirus

typically subclincal

86

diagnosis of adenovirus

adenoviral intranuclear inclusion bodies in intenstinal epithelium

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interesting fact about polyoma virus in hamsters

causes lymphoma as well as spontaneous skin epitheliomas

88

natural host for polyoma virus

European hamsters, transferto Syrian hamsters after inadvertently co0mingling of species

89

spread of polyoma virus

ingestion of virions through contaminated fomites

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tropism for polyoma virus

undiferentitated keratinocytes and lymphocytes

91

describe clincial signs of the two syndromes associated with polyoma virus

1) naive juvenile hamsters, epizootic multicentric lymphoma involving mesentary, intestines, liver, kidneys

92

transmission of polyoma virus

shed in urine (persists in renal tubular epithelium)

93

prevention and control of polyoma virus

culling of entire colony and decontamination

94

description of hamster parvovirus

rodent protoparvovirus 1, non enveloped singe stranded DNA virus

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natural host for rodent RPV1

not hamsters, most likely mice

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clinical signs of RPV1 infection in hamsters

young hamsters: runted with incisor teeth abnormalities, domes craniums, small testicles, and a potbellied appearance

97

transmission of RPV1

shed for long time in urnie, infection spred through ingestion of viral particles

98

diagnosis of RPV1

PCR

99

control of RPV1

quarantine, facility disinfection, re-stocking with new hamsters

100

hamsters are susceptable to what protozoa?

1) Spironucleus muris
2) Tritrichomonas muris
3) Giardia muris

101

clinical signs of protozoal infection in hamsters?

fecal smears from hamsters may contain a large number and variety of organims, yet etiologic role in disease is unclear.

102

Nematodes found in hamsters?

1) Syphacia mesocriceti
2) Syphacia stroma
3) Syphacia peromysci
4) Syphacia obvelata
5) Syphacia muris
6) Aspicularis tetraptera
7) Dentostomella translucida

103

life cycle of pin worms?

direct

104

transmission of pinworms?

fecal oral through fomites

105

cestodes found in hamsters?

1)Hymenolepis diminuta
2) Rodentolepis nana
3) Rodentopelpis microstoma

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most important parasite found in hamsters?

Rodentolepis nana

107

life cycle of Rodentolepis nana?

direct or indirect (unique)

108

diagnosis of cestodes?

fecal float. R. nana has hooks on the scolex

109

ascariasis in hamsters

1) Demodex criceti
2) Demodex aurati
3) Demodem cricetuli (Armenian only)
4) Notoedres (ear mite)
5) Spleorodens clethrionomys (nasal mite)

110

clinical signs of demodex infection

alopecia over rump and back with dry scaly skin

111

most frequent neoplasia of syrian hamster

lymphosarcoma

112

principal cause of death in hamsters on long-term experiments

amyloidosis

113

clinical signs of amyloidosis

affects liver, kidneys, stomach, adrenal, thyroid, and spleen. extensive subcutaneous edema, ascites and hydrothorax. pale tam, enlarged and misshapen kidneys

114

experimental induction of amyloidosis

casein or LPS subcutaneous injections

115

most common site for polycystic disease in hamsters

liver, but also cecum, kidneys, ovaries, and spleen

116

cause of cysts in polycystic disease

in liver- developmental defect of normal ductal structures

117

eitology for chronic hepatitis and cirrhosis

linked to dietary contamination, infection with bacterial pathogens, immune system abnormalities, but no etiology has been identified

118

clinical signs associated with chronic hepatitis and cirrhosis

no clincal signs, even in cirrhotic animals

119

atrial thrombosis is most commonly seen in which type of hamster?

albion-panda-albino (APA). accompanied by cardiac hypertrophy that develops with age.

120

pathogenesis of atrial thrombi

form as a result of local blood stasis secondary to heart failure

121

unique characteristics of the chinese hamster

small size

122

most common use for the chinese hamster

ovaries to make Chinese hamster ovary cell line

123

chromosome number for chinese hamster

22

124

most common metabolic disease seen in chinese hamsters

diabetes mellitus

125

cause of diabetes mellitus in chineese hamsters

transmitted as a recessive factor of 4 genes, if any two of the four genes are homozygous, glucosuria could result

126

most common spontaneous tumor in chinese hamsters?

uterine adenocarcinoma

127

cause of cerebral hemorrhage seen in chinese hamsters

not determined but postulated to involve inflammatory or degenerative changes in the anterior cerebral artery

128

characterization of periodontitis in hamsters

seen in chinese hamsters with hereditary diabetes melitus. lesion is characterized by absorption of alveolar bone, inflammation, and pocket formation due to splitting of the epithelial attachment. corrosponds to human disease with diabetes melitus

129

hamsters with diabetes melitus showed and increase in incidence of _____________ and __________________

peridontitis

130

uses of armenian hamster

susceptibility to mutagenic and carcinogenic agents

131

gestation of armenian hamster

18-19 days

132

most common spontaneous disease in armenian hamsters

hepatocellular carcinoma in animals exposed to estrogens

133

speical mite found in the armenian hamster

Demodex cricetuli

134

use of european hamster

susceptible to DEN (N-diethylnitrosamine) for development of respiratory tumors

135

most common neoplasia in european hamster

leukemia

136

coat difference between P. sungorus and P. campbelli

P. sungorus molts to a pure white haircoat while P. campbelli retains its grey haircoat

137

uses of djungarian hamsters

susceptible to carcinogens, and oncogenic viruses

138

estrus cycle of djungarian hamsters

most compressed reproductive cycle, post partum estous, day of parturition, deliver the second litter while weaning the first.

139

unique trait in reproduction of dungarian hamsters

both sexes take part in caring for young, females are typically non aggressive

140

hibernation of dungarian

do not hibernate even when exposed to temperatures below -40C

141

neoplasia in dnungarian hamsters

oral neoplasia, skin, and mammary glands

142

hypersensitivity to what type of bedding material

cedar chips

143

what characteristics make hamsters good subjects for oncology research

relaively low incidence of naturally occuring tumors
neonates are susceptible to viral oncogenesis
susceptible to estrogen induced tumors (renal adenocarcinoma in males)
resistant to radiation induced tumors

144

what characteristics make hamsters a good subject for immunobiology research?

neonatal hamster is immunologically immature
thymus is slow to mature

145

which species of hamster is a true hibernator

European hamster (Cricetus cricetus)

146

hibernation activity of Syrian hamster

(Mesocrecitus auratus) permissive hibernators, must awaken periodically

147

hamster pharmacology: resistant to which?

histamine, morphine, radiation

148

hamster pharmacology: sensitive to?

steroids and serotonin

149

hamster response to radiation

very resistant

150

are males or females more susceptible to amyloidosis

Females

151

reproductive characteristics of Phodopsus spp

females are nonaggressive, form monogamous parental bonds and both care for young