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Flashcards in NW and OW NHP models Deck (209)
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1

Callithrix spp are used for

Parkinson's disease

Multiple sclerosis

hemochromatosis

infectious diseases (hepatitis, EBV, malaria)

 

2

Saguinus spp used for

viral hepatitis 

colonic adenocarcinoma

inflammatory bowel disease

viral oncology 

3

Saimiri spp used for

pharmacology/toxicology

infectious disease( malaria, CJD, spong encephala)

labor and pelvic organ prolapse

stress, aging

4

Cebus spp used for

pharmacology/toxicology

viral oncogenesis

purine metabolism

atherosclerosis

nutrition

5

Aotus spp used for

infectious diease (malaria, leishmaniasis, viral oncogeneic viruses, viral hepatitis A) glomerulonephritis

atherosclerosis

immunology

vision

6

Lagothrix spp used for

(Woolly monkey)

hypertension

cardiovascular research

hepatitis B virus

7

animal model for dental carries

all NHP

8

creation of induced model for dental carries

experimentally induced with Strep mutans combined with daily meals rich in sugar

9

animal model for chronic destructive periodontitis

Callithrix jacchus

10

creation of induced model for chronic destructive periodontitis

induce experimentally by placement of peri-dental silk ligatures or orthodontic elastics as well as surgical removal of alveolar bone

11

animal model for Bacillary Dysentery/Shigellosis

most NHP, gorillas seem to be very susceptible

12

species of Shigellosis responsible for dysetery

S. flexneri, boydii, sonnei

13

clinical signs of Bacillary Dysentery

edematous face, liquid stools with mucus and blood.  Clinical features and gross microscopic lesions of the colon of the monkey infected with shigellae are indistinguishable from human shigellosis.  colonic changes are similar to those in man

14

animal model for Helicobacter gastritis

Old and New World Primates

15

purpose of model for Colibacillosis

evaluation of a prototype enterotoxigenic E. coli subunit vaccine

16

animal model for Enteropathogenic Colibacillosis

Pan tryglodytes, Pongo pygmaeus

17

characteristics of Enteropathogenic Colibacillosis

clinical and pathological features are similar to those in human infants.  Same E. coli serotypes are found.  studied in anthropoid apes, under 2 years of age.

18

animal model for Campylobacteriosis

Aotus nancymae, clinical course similar to that observed in humans

19

animal model for Cryptosporidosis

Macaca nemestrina

20

creation of induced Cryptosporidiosis model

inoculation of oocysts via nasogastric tube results in clinical enteritis and fecal passage of large numbers of cryptosporidial oocysts.  partial acquired immunity has been demonstrated

21

animal model for Helicobacter gastritis

old and new world NHPs

22

characteristics of Helicobacter gastritis model

NHPs commonly have subclinical infections but with histologic evidence of chronic gastritis and are often co-infected with H. pylori.  Rhesus have been used to induce H. pylori gastritis and for therapeutic vaccine trials

23

animal model for colonic adenocarcinoma

Saguinus oedipus

24

characteristics of model for colonic adenocarcinoma

spontaneously occurring primary adenocarcinoma of cecum, colon, and rectum, related to marmoset wasting disease

25

animal model for ulcerative colitis

Saguinus oedipus

26

model for ulcerative colitis

spontaneous, associated with decreased fecal short-chain fatty acid levels, progressive inflammation in a pattern similar to human colitis

27

purpose of model for ulcerative colitis

assess new treatments of inflammatory bowel disease

28

animal model of colitis cystica profunda

Saguinus mystax and S. labiatus, spontaneous

29

human disease of cystica profunda

characterized by mucus-filled cysts in the colonic and cecal mucosa, submucosa and muscularis propria, frequently lined by demonstrable epithelium, etiology unknown

30

animal model for Chron's disease

Saguinus mystax and S. labiatus