NW and OW NHP models Flashcards Preview

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Flashcards in NW and OW NHP models Deck (209)
1

Callithrix spp are used for

Parkinson's disease

Multiple sclerosis

hemochromatosis

infectious diseases (hepatitis, EBV, malaria)

 

2

Saguinus spp used for

viral hepatitis 

colonic adenocarcinoma

inflammatory bowel disease

viral oncology 

3

Saimiri spp used for

pharmacology/toxicology

infectious disease( malaria, CJD, spong encephala)

labor and pelvic organ prolapse

stress, aging

4

Cebus spp used for

pharmacology/toxicology

viral oncogenesis

purine metabolism

atherosclerosis

nutrition

5

Aotus spp used for

infectious diease (malaria, leishmaniasis, viral oncogeneic viruses, viral hepatitis A) glomerulonephritis

atherosclerosis

immunology

vision

6

Lagothrix spp used for

(Woolly monkey)

hypertension

cardiovascular research

hepatitis B virus

7

animal model for dental carries

all NHP

8

creation of induced model for dental carries

experimentally induced with Strep mutans combined with daily meals rich in sugar

9

animal model for chronic destructive periodontitis

Callithrix jacchus

10

creation of induced model for chronic destructive periodontitis

induce experimentally by placement of peri-dental silk ligatures or orthodontic elastics as well as surgical removal of alveolar bone

11

animal model for Bacillary Dysentery/Shigellosis

most NHP, gorillas seem to be very susceptible

12

species of Shigellosis responsible for dysetery

S. flexneri, boydii, sonnei

13

clinical signs of Bacillary Dysentery

edematous face, liquid stools with mucus and blood.  Clinical features and gross microscopic lesions of the colon of the monkey infected with shigellae are indistinguishable from human shigellosis.  colonic changes are similar to those in man

14

animal model for Helicobacter gastritis

Old and New World Primates

15

purpose of model for Colibacillosis

evaluation of a prototype enterotoxigenic E. coli subunit vaccine

16

animal model for Enteropathogenic Colibacillosis

Pan tryglodytes, Pongo pygmaeus

17

characteristics of Enteropathogenic Colibacillosis

clinical and pathological features are similar to those in human infants.  Same E. coli serotypes are found.  studied in anthropoid apes, under 2 years of age.

18

animal model for Campylobacteriosis

Aotus nancymae, clinical course similar to that observed in humans

19

animal model for Cryptosporidosis

Macaca nemestrina

20

creation of induced Cryptosporidiosis model

inoculation of oocysts via nasogastric tube results in clinical enteritis and fecal passage of large numbers of cryptosporidial oocysts.  partial acquired immunity has been demonstrated

21

animal model for Helicobacter gastritis

old and new world NHPs

22

characteristics of Helicobacter gastritis model

NHPs commonly have subclinical infections but with histologic evidence of chronic gastritis and are often co-infected with H. pylori.  Rhesus have been used to induce H. pylori gastritis and for therapeutic vaccine trials

23

animal model for colonic adenocarcinoma

Saguinus oedipus

24

characteristics of model for colonic adenocarcinoma

spontaneously occurring primary adenocarcinoma of cecum, colon, and rectum, related to marmoset wasting disease

25

animal model for ulcerative colitis

Saguinus oedipus

26

model for ulcerative colitis

spontaneous, associated with decreased fecal short-chain fatty acid levels, progressive inflammation in a pattern similar to human colitis

27

purpose of model for ulcerative colitis

assess new treatments of inflammatory bowel disease

28

animal model of colitis cystica profunda

Saguinus mystax and S. labiatus, spontaneous

29

human disease of cystica profunda

characterized by mucus-filled cysts in the colonic and cecal mucosa, submucosa and muscularis propria, frequently lined by demonstrable epithelium, etiology unknown

30

animal model for Chron's disease

Saguinus mystax and S. labiatus

31

chracteristics of model for Chron's disease

spontaneous terminal ileitis resembling Chron's disease in humans has been reported. etiology unknown, primary lesion is ulceration and thickening of the terminal portion of the ileum

32

animal model for Atherosclerosis

Cebus spp, Saimiri sciureus, addition of cholesterol to the diet results in hypercholesterolemia and exacerbation of atherosclerosis

Macaca mulatta, fascicularis, Chlorocebus aethiops, Papio spp

 

33

characteristics of spontaneous model for atherosclerosis

can study plaque regression and atherogenesis studies, and also effects of multiple risk factors suck as diet, stress, hormones, pharmacologic agents, and psychosocial factors

34

animal model for hypertension

Aotus nancymae, Lagothrix lagotricha

 

 

35

characteristics of model for hypertension

spontaneous, neural based, hyperactive responses of the sympathetic nervous system

36

animal model for infantile strabisus

Saimiri spp

 

Macaca nemestrina, fascicularis,

Papio cynocephalus

37

characteristics of model for strabismus

esotropia in newborm monkeys by surgical tenotomy of both lateral rectus muscles

or injection of Botulinum A neurotoxin (reversible, can study recovery)

 

38

animal model for retinal ganglion cell morphology

Callithrix jacchus

39

characteristics of model for retinal ganglion cell morphology

good visual acuity and its retinal and subcortical pathways are very similar to humans

40

animal model for retinal degeneration

Saimiri spp

41

characteristics of model of retinal degeneration

spontaneous retinal degeneration similar to human degenerative disorder

42

animal model for retinal detachment

Aotus spp

43

characteristics of model for retinal detachment

correlations of naturally occurring detachments with long-term retinal detachment in owl monkeys

44

animal model for myopia

Callithrix jaccus

Macaca mulatta, arctoides  (cats, tree shrews, marmosets, guinea pigs, and chickens)

 

45

characteristics of model for myopia

induced in infant animals, eyelids are surgically fused at birth and kept closed for one year

46

animal model for motion sickness

Saimiri spp

47

characteristics of model for motion sickness

induces by vertical oscillation and horizontal rotation, squirrel monkeys will vomit and are more active during test than most other NHPs

48

uses of model of motion sickenss

testing anit-motion sickness preparations

49

animal model of lymphocytic thyroiditis

Callithrix jacchus

50

characteristic of model of lymphocytic thyroiditis

chronic lymphyocytic auto-immune thyroiditis in conjunction with circulating antibodies to thyroid antigen, marmoset lesions are comparable to humans, marmosets show same sex predilection as seen in humans

51

animal model for stress

Saimiri, Callithrix

52

characteristics of model for stress

total circulating cortisol is 10 times greater than in humans, thought to be due to the disruptive presence of immature offspring that produces a chronic cortisol increase in captive adult squirrel monkeys

53

animal model for erythroblastosis fetalis

marmosets Callithrix spp

54

animal model for IgE studies

Callithrix jacchus

55

characteristics of erythroblastosis fetalis

similar fetoplacental situation, knowledge of blood groups

56

animal model for toxoplasmosis

Lagothrix lagothricha, Aotus lemurinus

57

characteristics of toxoplasmosis in NHP model

acute spontaneous, more frequent in NW than OW, a single case report in a male woolly monkey, source eating raw meat

58

animal model of malaria

Aotus spp, Saimri spp

 

Chipmanzee, Macaca mulatta

59

species of Malaria causing disease in man

Plasmodia falciparum, malariae, vivax, ovale

60

characteristics of malaria model

Aotus are susceptible to P. vivax, malaria is host specific, , S boliviensis are susceptible to infection with P. falciparum and different strains of P. vivax

Chimpanzees are the only known host for P. ovale

M.mulatta can be infected with a virulent strain of P. knowlesi

 

61

what species does the world health organization recommend as a model for evaluation of malaria vaccine candidates

Aotus nancymae

62

animal model for Haemobartonellosis

Saimri spp

63

characteristics of model for Haemobartonellosis

patent infection occurs following splenectomy, carriers commin in colony reared squirrel monkeys. reason for treating splenectomized squirrel monkeys with oxytetracycine before use in malaria studies.

64

animal model for Chaga's Disease

Cebus paella, chronic chagasic cardiomyopathy

65

characteristics for model of Chaga's Disease

cardiac lesions, focal or multifocal mononuclear infiltrates and/or isolated fibrosis

66

animal model for Cutaneous and Visceral Leishmaniasis

Aotus spp, Saguinus geoffroyi

visceral leshmaniasis- Chlorocebus aethiops

(hamsters are original animal model)

67

characteristics of model for Leishmaniasis

NHP develop self-limiting skin lesions with L. braxiliensis complex and severe to fatal visceral disease with L. donovani. transmitted by sandflies

68

animal model for Lymphocytic Choriomeningitis Virus Infection

Cebus albifrons

 

also: Macaca mulatta and fascicularis

69

characteristics of LCMV model

most common syndrome is meningitis nearly all LCM patients recover

70

animal model for yellow fever

Marmosets, tamarins, owl, spider, and squirrel monkeys, rhesus

 

71

characteristics of model of yellow fever

pathological species seen in NHP is similar to those in man

 

M. mulatta= disease resembles hyperacute form seen in man

NW are all extremely susceptible, except Cebus which are usually asymptomatic and Ateles are resistant

72

animal model for Dengue fever

Aotus nancymae

73

characteristics of Dengue fever model

Aotus develops viremia but no Dengue fever, or Dengue shock syndrome like humans

74

animal model of Eastern Equine Encephalitis

Aotus nancymae

75

characteristics of EEE model

A. nancymae sustains short term viremia and produces IgM and IgG post EEEV infection but no clinical disease, non-lethal model for evaluation of candidate vaccines against EEEV

76

animal model of Argentinian Hemorrhagic Fever

Callithrix jacchus

77

characteristics of Argentinian Hemorrhagic Fever

experimentally induced disease is quite similar to the natural infection of man

78

animal model of measles

Saimiri sciureus, Saguinus mystax

Masaca fascicularis

 

79

characteristics of model of measles

severe disease when introduced to captive NW monkey, typically see GI effects such as necrotizing colitis

80

animal model for human T-cell Lymphotropic virus (non-hodgkin's lymphoma)

squirrel monkeys

Papio sp

81

characteristics of HTLV

chronically infected monkeys developed high titers of antibodies against structural proteins of the virus, as do HTLV humans, squirrel monkeys may be useful to study the pathogenesis of HTLV and for evaluating new candidate vaccines

HTLV is similar to STLV-1

82

animal model for Epstein-Barr Virus

Callithrix jacchus

Macaca mulatta

83

characteristics of EBV model

the B95-9 strain of EBV induces malignant lymphomas in cotton top tamarins, used to evaluate EBV vaccines

 

in Macaques develop key aspects of human infection

84

animal model fro Klebsiella pneumonia

SQuirrel monkey, marmosets

85

characteristics for Klebsiella

lobar pneumonia develops after administration of only 700 organisms

86

animal model for Helicobacter pylori infection

Saimiri spp

87

characteristics of Helicobacter infection model

experimentally induced infection in Saimiri, used in immunogenicity and safety studies

88

which hepatitis viruses are enterically transmitted?

A and E

89

which hepatitis viruses are parenterally transmitted?

B,C, delta

90

which hepatitis viruses produce disease in both OW and NW primates

A and E

91

which viruses induce hepatitis in only a few OW species

B,C, delta

92

which NHP species are susceptible to both Hep A and B

marmosets and chimpanzees

93

which NHP species are most susceptible to Hep E

cynos and Aotus monkeys

94

what is the animal model for Hep A

Aotus spp, Marmosets and Tamarins

95

model of choice for Hep A research

Marmosets

96

model of choice for Hep B research

Chimpanzee

97

model of choice for Hep E research

Aotus monkey

98

closest viral relative to Hep C that can be used as a model?

GBV-B, causes acute hepatitis, increased liver enzymes that quickly return to normal as virus is cleared

99

animal model for GBV-B as model for Hep C research

Saguinus spp, Callithrix jaccus

100

animal model for Cholelithiasis

Aotus spp, Callithrix jacchus, Saimiri spp

101

characteristics of Cholelithiasis

Aotus and Callithrix, not based on cholesterol in the diet, Squirrel monkey requires addition of cholesterol to the diet. The frequency of stone formation appears to be inversely related to the concentration of cholesterol in the plasma. There is a suggestion that regimens which lower plasma cholesterol may result in accelerated gallstone formation.

102

animal model of cholesterol cholelithiasis

Aotus spp

103

characteristics of cholesterol cholelithiasis

Aotus monkeys spontaneously develop cholesterol gallstones when fed a diet supplemented with 1.5% cholesterol.

104

NHP animal model for Gilbert's syndrome

Saimiri boliviensis

105

characteristics of model for Gilbert's syndrome

nonhemolytic unconjugated hyperbilirubinemia, defect in hepatic uptake of unconjugated bilirubin and/or a conjugating enzyme deficiency, plasma of normal Bolivian squirrel monkeys what are fasted for 24hrs have a hyperbilirubinemia. most likely due to the presence of the hepatic enzyme UDP-glucuronyl transferase that results in a higher plasma and hepatic bilirubin level during a fast.

106

animal model of hemochromatosis

Callithrix jacchus

107

characteristics of model of hemochromatosis

characterized by excessive absorption of ingested iron, saturation of iron-binding protein, and deposition of hemosiderin in tissues especially liver, pancreas, and skin. will seek Kupffer cells in the liver lining sinusoids eating all the hemosiderin

108

animal model of gout

Cebus, Ateles, Lagothrix, Saguinus spp

109

characteristics of model of gout

NHP and humans lack uricase leading to hyperuricemia with subsequent deposition of urates in and about the joints.

110

animal model of Parkinson's Disease

Callithrix jacchus

Macaca mulatta

Macaca nemestrina

Chlorocebus aethiops

111

characteristics of Parkinson's model

acute exposure to MPTP causes motor symptoms/signs indistinguishable from PD. Lewy bodys are the characteristic intracellular inclusion seen in the brain. MPTP induces and acute, toxic disorder associated with injury to nigral neurons, whereas PD is a chronically progressive disorder of unknown cause. Experimental animals do not develop the cognitive and memory impairments that occur in PD

112

animal model for Cerebral Beta-Amyloid Angiopathy

Saimiri spp

113

characteristics of Cerebral Beta-Amyloid Angiopathy

manifest beta-amyloid deposition in the cerebral blood vessels with age. used to test in vivo beta-amyloid labeling strategies

114

animal model for Multiple Sclerosis/ Experimental Allergic Encephalomyelitis

Callithrix jacchus

Macaca mulatta

Macaca fascicularis

115

characteristics of Multiple Sclerosis model

called experimental allergic or autoimmune encephalomyelitis. sensitization to myelin basic protein (BP) induces a cell-mediated delyated-type hypersensitivity reaction to host myelin

116

how do you causes relapsing remitting EAE

treat acute attack with dexamethasone for 3 days

117

animal model for Spongiform Encephalopathy

Saimiri spp, Saguinus spp

118

characteristics of Spongiform encephalopathy model

mental and physical abilities deterioriate and a myrial of tiny holes appear in the cortex, causing it to appear like a sponge.

119

animal model of neurodegenerative disease

aged Saimiri spp

120

characteristics of neurodegenerative disease model

aged NHP develop age associated behavioral and brain abnormalities similar to those in aged humans such as degenerative changes, neuritis and deposits of amyloid in senile plaques and around blood vessels

121

animal model for Lissencephaly

Saimiri spp

122

characteristics of Lissencephaly model

Saimiri is highest species of primate with a lissencephalic brain, used to study cortical spreading depression in a highly encephalized brain

123

animal model for Viral Encephalitis and epilepsy

intracerebral injection with canine distemper virus (CDV), causes acute neurological signs of viral encephalitis such as seizures and myoclonus, lesions resemble childhood acute viral encephalitis and subacute sclerosing panencephalitis

124

animal model for Torticollis

Callithrix jacchus

125

characteristics of model for Torticollis

unilateral injection of 6-hydroxy-dopamine into the lateral hypothalamus resulted in persisting (days to weeks) severe torticollis with the head deviated toward the side of the lesion

126

animal model of Adenosis and clear cell adenocarcinoma of the vagina and cervix

Cebus apella

127

characteristics of model of Adenosis and clear cell adenocarcinoma of the vagina and cervix

in utero exposure to DES (diethylstilbestrol

128

animal model of Chlamydial infections

NW, OW, and great apes

129

characteristics of animal model of Chlamydial infections

Chlamydia trachomatis infection of primate genital tract, pathologic changes similar to humans. Owl monkey model for ocular trachoma

 

Trachoma is major blinding disease

130

animal model for Twinning, Chimerism, and immunologic tolerance

Callithrix and Saguinus spp

131

characteristics of twining model

blood chimerism is the norm in marmoset twins as functional vascular anastomosis between fetuses always occur. As in humnas, the freemartin condition does not occur

132

animal model of labor and pelvic organ prolapse

Saimiri spp

133

characteristics of labor and pelvic organ prolapse

fetal rotation occurs like in women,

134

animal model for Legionnaires' Disease

Callithrix jacchus

Macaca mulatta

Chlorocebus aethiops

(cavia porcellus most susceptible)

135

production of Legionnaires' model

production of small particle aerosol of L. pneumophila which mimics that inhaled by patients.

136

characteristics of Legionnaires' model

acute fibrinopurulent bronchopneumonia, organism survives and multiplies in lung macrophages

137

animal model for Ankylosing Spondylitis

aged Squirrel monkeys

138

characteristics of model for ankylosing spondylitis

signs usually in older animals, affected monkeys are reluctant to move, may refuse to rise and are likely to be attacked by cage mates. Spondylitis usually begins in sacroiliac joints.

139

animal model for cartilage allografts

Callithrix jacchus

140

characteristics of cartilage allografts

transplanted allografts of cultured mandibular condylar cartilage appeared to have the ability to promote cartilaginous repair and regeneration of orthopedic articular wounds

141

animal model for Syndactyly

Saguinus nigricollis

142

characteristics of Syndactyly model

abnormal soft tissue union of the digits, antosomal recessive trait

143

animal model for repetitive strain injury

Aotus spp

144

characteristics of repetitive strain injury model

Aotus monkeys are trained to repetitively open and close a handpiece. Animals that used a rapid, stereotypical hand squeezing technique developed a task-specific movement dysfunction. Animals that used a variable shoulder-pulling strategy did not develop movement problems

145

animal model for lead poisoining

Saimiri, Cebus

146

characteristics of lead poisoining model

occurs in infants with pica, signs similar to those seen in man. Notable difference is the presence of demylination in some simian brains and spinal cords not reported to occur to a significant degree in man. clinical signs are weakness, paralysis, amaurosis (vision loss or weakness that occurs without an apparent lesion affecting the eye)

147

animal model for Thalidomide syndrome

Callithrix jacchus

148

animal model for vesicoureteral reflux

NHP, but Rhesus are ideal

149

characteristics of vesicoureteral reflux model

NHPs show same low incidence of chronic phelonephritis and vesicoureteral reflux as pregnant women and infants

150

animal model of hydronephrosis of pregnancy

any NHP

151

characteristics of hydronephrosis of pregnancy

incidence same in man and monkey, right ureter most often affected, caused by obstruction of ureter by gravid uterus.

152

animal model of carcinoma of the urinary bladder

Cebus apella

153

characteristics of carcinoma of the urinary bladder model

inflammatory response to schistosome eggs produce acute and chronic cystitis and uteritis, develop multifocal urethelial lesions that tend to regress as the infection become less active and changes are more hyperplastic rather than neoplastic

154

animal model of Burkitts lymphoma

Saguinus oedipus, Aotus, Ateles geoffroyi

155

characteristics of Burkitt's lymphoma

herpesvirus saimiri and ateles isolated from apparently healthy squirrel and spider monkeys respectively. H. saimiri in tamarins, spider monkeys and owls produces malignant lymphoma with leukemia. H. ateles can induce in S. oedipus

156

animal model for hemolytic anemia of premature infants

Cebus albifrons, apella

157

characteristics of hemolytic anemia of premature infants

induced in young growing animals fed diets high in polyunsaturated fats, NW are more susceptible

158

animal model for folate deficiency, megaloblastic anemia

Cebus albifrons

159

characteristics of folate deficiency diet

three year old Cebus albirfons were fed a folate deficient diet and developed same stage of disease that humans did

160

Cercocebus atys are a model for?

AIDS/SIV/ leprosy

161

Chlorocebus spp are a model for?

Yellow fever, plague, leprosy, Hepatitis, Legionnaires' Disease, varicella, atherosclerosis

162

Erythrocebus patas are a model for?

pregnancy toxemia, Varicella infection

163

Chimpanzees are a model for?

AIDS, Hepatitis A,B, C,E, vaccine development and final safety testing, congnition and language development

164

animal models for HIV

Macaca arctoides, cyclopis, fascicularis, mulatta, nemestrina, Pan troglodytes, Papio spp

165

characteristics of HIV infection in macaques

cannot be infected with HIV-1. Pig tailed macaques can be infected but fail to develop disease. HIV2 (more similar to SIV) can infect pig-tailed macaques and baboons

166

characteristics of SIV infection

outside their normal host range, especially in macaques, these viruses cause an AIDS like disese similar to that of HIV infected patients

167

natural hosts for SIV infection

African green monkeys, sooty mangaby

168

animal model for cardiopulmonary disease/ pulmonary hypertension, cor pulmonale and endocardial fibroelastosis

Macacca arctoides

169

characteristics of induced model of pulmonary hypertension

2% monocrotaline solution injected SQ in infant M. arctoides

170

animal model for macular cyst

Macaca fascicularis

171

induction of animal model for macular cyst

injec Perfluoropropane (C3F8) into the eye, develop in about 3 months after injection

172

animal model for diabetes mellitus 

Macaca nigra is classic

173

ABO blood group antigens are present on which cell types

endothelial cells, exocrine secreations, primary sensory neurons,

 

NOT ERYTHROCYTES, use saliva for typing not blood

174

animal model for varicella infection

Erythrocebus patas

Chlorocebus aethiops

175

life cycle of malaria

sporozoite penetrates and goes to hepatocyte to become trophozoite matures to Schizont, differentiates into merozoite that invades RBS's

176

animal modesl for leprosy

Cercocebus torquatus atys

Pan troglodytes

Chlorocebus aethiops

Macaca mulatta

177

animal model for Tuberculosis

Macaca fascicularis

178

characteristics of animal model for TB

Macaca fascicularis is the first good model for chronic TB in humans, develop pulmonary disease in people with progression to clinical syndromes

179

animal model for male pattern baldness

Macaca arctoides

180

animal model for nonalcholic fattly liver disease

Macaca radiata

181

animal model for meningoencephalocele

MAcaca mulatta

182

183

184

animal model for saccular cerebral aneurysms

NHPs in general

185

creation of induced animal model for saccular cerebral aneurysms

ligation of one common carotid artery, production of experimental hypertension and feeding of A-aminopropionitrile

186

animal model for hydrocephalus

Macaca mulatta

187

creation of induced animal model of congenital hydrocephalus

intracerebral inoculation with an attenuated influenza A vaccine cirus in fetal monkeys

188

animal model for huntington's disease

Macaca fascicularis

Papio sp

189

creation of induced model of Huntington's disease

 chronic administration of 3NP

injections of quinolinic acid into the striatum

190

animal model of toxemia of pregnancy

Erythrocebus patas

191

characteristics of spontaneous model of Toxemia of Pregnancy

abrupt onset between day 7 prepartum and the day of parturition

does not progress beyond preeclamptic stage

192

animal model for preeclampsia

Macaca mulatta

193

induction of model for preeclampsia

chronic constriction of the lower aorta

194

animal model for gonorrhea

Pan troglodytes

195

characteristics of model of Gonorrhea

Chimpanzee is unique in its susceptibility to mucosal surface infection, can study pathogenesis, mechanisms of host response, treatments, and vaccines

196

animal model for endometriosis

Macaca mulatta

197

Animal model for resentosis

Cynomologys monkeys

198

characteristics of model for restenosis

fed an atherogenic diet for 3 months

angioplasty performed

response to angioplasty appears to closely resemble that in humans

199

animal model for scrub typhus

Macaca fascicularis

Presbytis cristatus

200

characteristics of Scrub typhus model

Rickettsia tsutsugamushi

cynos develop same clinical response as humans

201

animal model for lymp neuroborreliosis

Macaca mulatta

202

characteristics of model for Lyme Neuroborreliosis

Lyme= Borelia burgdorferi, 

macaques demonstrate many of the clinical and pathological features of the disease in humans including cutaneous rash, myocarditis, CSF pleocytosis, and CNS meningitis

203

animal model for cytomegalovirus

Macaca mulatta

 

204

characteristics of model of cytomegalovirus

infection of Rhesus with rhesus cytomegalovirus is model for human cytomegalovirus infection

lessons learned from RhCMV should have direct clinical relevance to HCMV and the design of protective vaccines

205

animal model of alzheimer's disease

aged Macaca mullata

206

characteristics of model for alzheimer's disease

have progressive cerebral deposition of the amyloid beta-protein

207

animal model for Experimental Allergic Encephalomyelitis

Macaca mulatta

Macaca fascicularis

marmosets

208

creation of animal model for Experimental Allergic Encephalomyelitis

intradermal injection of homologous myelin basic protein in CFA

 

causes a delayed type hypersensitivity reation to host myelin, leads to fatal demyelinating, necrotizing inflammation in the brain and spinal cord

209