Flashcards in Guide questions Deck (58)
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1
define engineering standard
a standard or guideline that specifies in detail a method, technology, or technique for achieving a desired outcome. They are prescriptive and provide limited flexibility for implementation.
2
define performance standard
a standard or guideline that, while describing a desired outcome, provides flexibility in achieving this outcome by granting discretion to those responsible and the IACUC.
3
define practice standard
application of professional judgment by qualified, experienced individuals to a task or process over time
4
define policies
commonly derive from a public agency or private entity. generally practical statements of collective wisdom, convention, management direction that are internal to the entity.
5
define principles
broader in scope and intended application, accepted generalizations about a topic that are frequently endorsed by many and diverse organizations
6
define procedures
detailed, step by step processes meant to ensure the consistent application of institutional practices
7
define animal care and use program
comprises all activities conducted by and at an institution that have a direct impact on the well-being of animals, including animal and veterinary care, policies and procedures, personnel and program management and oversight, occupational health and safety, institutional animal care and use committee functions and animal facility design and management.
8
who has the primary oversight responsibiliites for the animal care and use program?
IO, AV, IACUC
9
describe the authority of the IO
authority to allocate the resources needed to ensure the program's overall effectiveness
10
describe the authority of the AV
sufficient authority, including access to all animals, and resources to manage the program of veterinary care. The AV should also oversee other aspects of animal care and use to ensure that the Program complies with the Guide
11
describe the authority of the IACUC
assessment and oversight of the institutions program components and facilities.
12
who is responsible for providing appropriate resources to support personnel training to both animal care staff and the research team?
institutions
13
who is responsible for providing oversight and for evaluating the effectiveness of the training program?
the IACUC
14
what are the essentail components of any training program?
1) animal care and use legislation
2) IACUC functions
3) ethics of animal use and the concepts of the 3Rs
4) methods for reporting animal use concerns
5) occupational health and safety concerns related to animal work
15
what are the areas and levels of responsibility for an occupational health and safety plan?
1) hazard identification and risk assessment
2) control and prevention strategies
to include design and engineering controls, process or administrative controls, then PPE
16
according to the guide, the IACUC committee should consist of:
1) doctor of veterinary medicine
2) at least one practicing scientist experienced in research involving animals
3) at least one member from a nonscientific background, drawn from inside or outside the institution
4) at least one public member to represent general community interests
17
what three factors should be considered when developing a protocol that involves food and/or water restriction?
1) necessary level of restriction
2) potential adverse consequences of restriction
3) methods for assessing the health and well-being of the animals, should be weighed once weekly
18
when using non pharmaceutical grade chemicals, what factors should be considered?
grade
purity
sterility
pH
pyrogenicity
osmolality
stability
site and route of administration
formulation
compatibility
pharmacokinetics
19
what is the thermoneutral zone for mice?
26-34C
20
what is the thermoneutral zone for rats?
26-30C
21
what is the thermoneutral zone for gerbils?
28-32C
22
what is the thermoneutral zone for rabbits?
15-20C
23
what it the thermoneutral zone for dogs?
20-25C
24
what is the thermoneutral zone for nonhuman primates?
depends on species
25
what are some factors that contribute to variation in temperature and humidity between and within enclosures?
housing design, construction material, use of filter tops, enrichment devices, number-age-type-size of the animals in the enclosure, forced ventilation, type and frequency of contact bedding changes
26
when selecting a housing temperature, what factor(s) should be considered?
room temp should be below the lower critical threshold of the thermoneutral zone. This helps to prevent heat stress. To help with cold stress, nesting material and enrichment should be provided.
27
what is the recommended housing temp for mouse, rat, hamster, gerbil, guinea pig?
20-26C (68-79F)
28
what is the recommend housing temp for rabbits?
16-22C (61-72F)
29
what is the recommended housing temp for cats, dogs, and nonhuman primates
18-29C (64-84F)
30
