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Flashcards in other mouse models Deck (21)
1

list the mouse models for retinal degeneration

C3H
FVB
SJL
CBA
outbred swiss

2

what is the mutation that is responsible for retinal degeneration?

rd1 mutation of the Pde6b gene

3

what is the defect seen in the obese mouse

Lep ob- leptin deficient

4

what is the defect seen in the diabetes mouse

Lepr db- leptin receptor deficient

5

on what chromosome is the gene coding for the leptin hormone?

Chr 6

6

on what chromosome is the gene coding for the leptin receptor?

Chr 4

7

what factors play a role in the development of the NOD diabetic model?

insulitis, T cell autoimmunity against islet cells. similar to type 1 diabetes,

8

which mouse is a model for hodgkin's lymphoma

SJL mice

9

what is the process for creating a mouse model of allergic athsma

exposure to ovalbumin, IL4 knockout mice are sometimes used

10

which strains are susceptible to audiogenic seigures

DBA
SJL
some FVB

11

what is the mouse model for pituitary adenoma>

FVB

12

what is the mouse model for teratoma

129

13

characteristics of Apolipoprotein E deficient mouse

increased total cholesterol
spontaneously develop aterial lesions
atheroscelrosis progression similar to humans
lesions develop more quickly if fed a Western diet

14

characteristics of LDL receptor KO mouse

high cholesteral levels on regular and even higher on high fat diet
-atherosclerosis, fatty liver disease

15

characteristics of lethal yellow mouse?

homozygotes die as embryos
obesity, insulin resistance, hypergylcemia
elevated malic enzyme in liver

16

AKR as susceptible to what cancer

leukemia, associated with retrovirus
thymic lymphoma

17

SJL are susceptible to what cancers

reticulum cell sarcomas (hodgkins lymphoma)

18

induction of EAE in SJL mice

immunization with proteolipid protein (PLP), myelin basic protein (MBP), or peptides corresponding to immunodominant epitopes MBP

19

A/J and A/He mice are susceptible to what cancers

lung tumors
mammary adenocarcinomas

20

piebald lethal mutation is on what locus

Ednrb(s-l)

21

characteristics of piebald lethal mutation

disrupts development of melanocytes derived from neural crest
model for Hirschsprung's disease, Waardenburg syndrome