Flashcards in other mouse models Deck (21)
list the mouse models for retinal degeneration
what is the mutation that is responsible for retinal degeneration?
rd1 mutation of the Pde6b gene
what is the defect seen in the obese mouse
Lep ob- leptin deficient
what is the defect seen in the diabetes mouse
Lepr db- leptin receptor deficient
on what chromosome is the gene coding for the leptin hormone?
on what chromosome is the gene coding for the leptin receptor?
what factors play a role in the development of the NOD diabetic model?
insulitis, T cell autoimmunity against islet cells. similar to type 1 diabetes,
which mouse is a model for hodgkin's lymphoma
what is the process for creating a mouse model of allergic athsma
exposure to ovalbumin, IL4 knockout mice are sometimes used
which strains are susceptible to audiogenic seigures
what is the mouse model for pituitary adenoma>
what is the mouse model for teratoma
characteristics of Apolipoprotein E deficient mouse
increased total cholesterol
spontaneously develop aterial lesions
atheroscelrosis progression similar to humans
lesions develop more quickly if fed a Western diet
characteristics of LDL receptor KO mouse
high cholesteral levels on regular and even higher on high fat diet
-atherosclerosis, fatty liver disease
characteristics of lethal yellow mouse?
homozygotes die as embryos
obesity, insulin resistance, hypergylcemia
elevated malic enzyme in liver
AKR as susceptible to what cancer
leukemia, associated with retrovirus
SJL are susceptible to what cancers
reticulum cell sarcomas (hodgkins lymphoma)
induction of EAE in SJL mice
immunization with proteolipid protein (PLP), myelin basic protein (MBP), or peptides corresponding to immunodominant epitopes MBP
A/J and A/He mice are susceptible to what cancers
piebald lethal mutation is on what locus