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Flashcards in other mouse models Deck (21)
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1
Q

list the mouse models for retinal degeneration

A
C3H
FVB
SJL
CBA
outbred swiss
2
Q

what is the mutation that is responsible for retinal degeneration?

A

rd1 mutation of the Pde6b gene

3
Q

what is the defect seen in the obese mouse

A

Lep ob- leptin deficient

4
Q

what is the defect seen in the diabetes mouse

A

Lepr db- leptin receptor deficient

5
Q

on what chromosome is the gene coding for the leptin hormone?

A

Chr 6

6
Q

on what chromosome is the gene coding for the leptin receptor?

A

Chr 4

7
Q

what factors play a role in the development of the NOD diabetic model?

A

insulitis, T cell autoimmunity against islet cells. similar to type 1 diabetes,

8
Q

which mouse is a model for hodgkin’s lymphoma

A

SJL mice

9
Q

what is the process for creating a mouse model of allergic athsma

A

exposure to ovalbumin, IL4 knockout mice are sometimes used

10
Q

which strains are susceptible to audiogenic seigures

A

DBA
SJL
some FVB

11
Q

what is the mouse model for pituitary adenoma>

A

FVB

12
Q

what is the mouse model for teratoma

A

129

13
Q

characteristics of Apolipoprotein E deficient mouse

A

increased total cholesterol
spontaneously develop aterial lesions
atheroscelrosis progression similar to humans
lesions develop more quickly if fed a Western diet

14
Q

characteristics of LDL receptor KO mouse

A

high cholesteral levels on regular and even higher on high fat diet
-atherosclerosis, fatty liver disease

15
Q

characteristics of lethal yellow mouse?

A

homozygotes die as embryos
obesity, insulin resistance, hypergylcemia
elevated malic enzyme in liver

16
Q

AKR as susceptible to what cancer

A

leukemia, associated with retrovirus

thymic lymphoma

17
Q

SJL are susceptible to what cancers

A

reticulum cell sarcomas (hodgkins lymphoma)

18
Q

induction of EAE in SJL mice

A

immunization with proteolipid protein (PLP), myelin basic protein (MBP), or peptides corresponding to immunodominant epitopes MBP

19
Q

A/J and A/He mice are susceptible to what cancers

A

lung tumors

mammary adenocarcinomas

20
Q

piebald lethal mutation is on what locus

A

Ednrb(s-l)

21
Q

characteristics of piebald lethal mutation

A

disrupts development of melanocytes derived from neural crest
model for Hirschsprung’s disease, Waardenburg syndrome