Flashcards in mouse immunodeficiency models Deck (24)
what mutation is present in nude mice?
what mutation is present in SCID mice?
deficiencies seen in nude mice
decreased T cells, but leaky
deficiencies seen in SCID mice?
decreased T and B cells, but leaky
deficiencies seen in SCID beige mice
decreased T, B and NK cell activity
deficiencies seen in NOD-SCID mice
decreased T, B, and NK activity, minimal leaky
deficiencies seen in NSG, or NOG mice
decreased T, B and NK activity, not leaky
what are the common medical complications seen in nude mice?
females fail to lactate
susceptible to Corynebacterium bovis
susceptible to Staph xylosus
lack of whiskers
what chromosome is the SCID mutation on?
what immunodeficiency is seen in the SCID mouse?
defective DNA dependent kinase coding for TCR and B cell receptors
what chromosome is the Rag mutation on?
what chromosome is the Beige mouse mutation on?
what is the cause of the immunodeficiency seen in the Beige mouse?
lysosomal storage disease
what is the cause of the immunodeficiency seen in the XID mouse?
defective Bruton's tyrosine kinase (signal transduction in B cells)
what immunodeficiency seen in the moth eaten mouse?
lacks cytotoxic T and NK cells
what is the cause of the immunodeficiency seen in the moth eaten mouse?
defective phosphatase, Chr 6
list two mouse models for systemic lupus erythematosus
NZB x NZW F1 hybrid
FAS lpr mouse
what chromosme is the Foxn1 (nude mouse) mutation on?
pathophysiology of immunodeficiency in nude mide
dysgenesis of thymic epithelium, lack measurable T cell activity, increased NK cell activity
major uses of nude mice
What immunodeficiency is seen in the Rag1 or 2 knockouts?
Antibody and T cell deficient, not leaky
What chromosome is the Rag 1 and 2 found on?
breeding of Foxn1nu animals
breed nude males with heterozygous females