Behavioural Illness Flashcards Preview

Jason's Neuro Block > Behavioural Illness > Flashcards

Flashcards in Behavioural Illness Deck (20):
1

Catatonia is?

motor immobility
extreme negativism/mutism

2

Islands of Reil AKA?

Insular cortex

3

Mental developmental disorders tend to start when?

puberty

4

what two types of glial cells are involved in behavioural illness?

microglia
astrocytes

5

how much metabolic rate is for brain?

25%

6

suggested that schizophrenia, problem with what in the synapses?

pruning
formulation

7

when does synaptic pruning happen in sensory cortex vs. frontal?

sensory: early
frontal: late

8

dendritic spine density in children is?

2-3x greater than adults

9

what's the most replicable finding of anatomical basis for mental illness?

connectivity

10

what regulates cell skeleton?

Wnt
GSK3b
synapsinI
MAP2

11

Schizophrenia have higher levels of what in microglia?

calprotectin

12

Mouse OCD with Hoxb8 can be rescued how?

bone marrow transplant

13

autism and microglia, which region and what happens?

dorsolateral prefrontal cortex (both white and bray matter)
overgrowth

14

increased what staining in autism?

HLA-DR

15

does increased density in DLPFC in autism is NOT related to? 2 things

seizures
inflammation

16

SNPs are?

single nucleotide polymorphism

17

Genetic classification of autism spectrum is 1st time we have what?

diagnostic test

18

where to parents of autistic children lie on the graph/spectrum?

between the control and autism subject scores

19

getting autism seems to be a balance between what genetically?

risk SNPs
resilience SNPs

20

do both monozygotic twins have to have autism if one has one?

Nope. One twin can have more protective SNPs