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Jason's Neuro Block > Pain > Flashcards

Flashcards in Pain Deck (33):
1

Pain is objective or subjective?

always subjective

2

what aspects to pain are where?

experience with sensory and emotional aspects

3

does tissue damage size = pain amount?

Nope. variable.

4

Nociception vs. pain?

Pain: reach conscious brain
nociception: before reach conscious brain

5

how is pain expressed?

in behaviour/communicated

6

nociceptors compared to somatosensory receptors?

nociceptors have higher threshold to transduction

7

nociceptive pain you get what reactions?

autonomic
withdrawal
acts as early warning

8

which nociceptors are myelinated? which faster?

A-delta (faster 3-30m/s)
C polymodals: unmyelinated (slower, <3m/s)

9

glabrous skin does not have what fibers?

A-delta fibres

10

first and second pains, how transmited?

A-delta: first
C: second

11

where are most pain receptors in dossal horn?

most are superficial

12

second order neurons project nociception via?

anterolateral tract
decussate at level of spinal cord

13

do all second order neurons project nociception up?

only 1 in 9, others make reflex circuits

14

how is nociceptive pain adaptive?

can signal potential tissue damage

15

What does the inflammatory pain do?

give info about the damage after the injury

16

describe inflammatory pain?

pain maintained continuously, tenderness promotes repair(protective)

17

What is TRPV1?

nociceptive ion transducer activated in hot chili peppers to capsaicin

18

what does polymodal mean?

neuron can depolarize due to multiple things: heat and mechanical

19

peripheral sensitization leads to what sensation?

primary allodynia and hyperalgesia due to sensitized terminal

20

what is secondary allodynia/hyperalgesia?

after CNS sensitization
also expanded region of sensitivity in nociceptive area

21

inflammatory pain purpose?

adaptive and reversible
protect during healing

22

inflammatory pain amplification? 2 ways

peripherally
centrally

23

2 kinds of maladaptive pain?

neuropathic: lesion: stroke, MS, trauma
dysfunctional: no lesion: migraine, fibro, pelvic

24

describe maladaptive pain:

spontaneous pain
pain hypersensitivity

25

what is peripheral neuropathic pain?

injury to primary sensory neuron anywhere along the transduction pathway

26

neuropathic pain purpose?

maladaptive, persistent
sensory amplification
low and high intensity stimuli

27

3 points for neuropathic pain:

1. central amplification
2. neuroimmune interactions, PNS/CNS
3. peripheral amplification via lesion or disease

28

how does emotional come into pain with chronic conditions?

emotional more of a role as condition becomes worse as it shifts from physiological to emotional processes

29

how does spinal control of pain modulation happen?

inflamm will engage descending pain modulation inhibit or facilitate nociceptive transmission in spinal cord

30

3 cortical areas associated with top-down psychological modulation of pain:

anterior cingulate
prefrontal
insula

31

can you modulate placebo?

yes via opiod antagonist, you can reduce placebo effect

32

What is Nocebo?

expectations of positive of negative beliefs will modulate pain felt

33

6 psychobiological model of pain:

injury
genetics
chemical/structural
context
mood
cognition