Flashcards in Cells of the CNS Deck (33):
immune cells in the CNS are called?
where are ependymal cells found?
line central canal of spinal cord
low columnar/cuboidal cells
purpose of ependymal cells?
aid CSF flow via cilia
4 big characteristics of Neurons:
Specialized for signalling
high level of protein synthesis
3 components of cytoskeleton and their function:
Microtubules: dynamic, axon transport
what is the metabolic centre of the neuron called?
two types of processes that come from neuron?
High proportion of total neuron volume are? 2 things
why is axonal transport critical?
because so much of the neuron is axon
nerve damage is usually where on the neuron?
axon because it's so long
Neuron input via dendrites is active or passive?
passive electrotonic spread
why do neurons have high protein production?
to make ion channels
What are Nissl bodies?
rough ER and ribosomes in neurons
Glial cells AKA:
Astrocytes have 5 key passive support functions:
neuronal energy supply
2 active functions of astrocytes:
modulate neuronal function
module neuronal blood flow
Glutamate does what?
GABA does what?
what happens when glutamate transporters on glial cells are inhibited
neurons are more depolarized, could die
What can excite a glia? 4 things
how can you prove glia is active?
modulation in intracellular calcium waves
How to glia communicate?
via synaptic vesicles and exocytosis
how does glia regulate neuron?
glia release ATP>calcium wave>inhibit neurons
Which glial cells surround blood vessels? what do they do?
difference between oligodendrocytes and schwann cells?
oligodendrocytes: CNS white matter
How many axons do oligodendrocytes vs. schwann cells?
oligodendrocytes: several axons
schwann: single axon
Where does microglia originate from?
bone marrow/macrophage lineage
microglia fast or slow?
fast: like innate system
microglia important for maintaining what?
normal brain function
what do microglia do if injury?
release cytokines (damaging)
change rapidly in response to inflammation
peripheral nerve have 3 layers
endoneurium: around individual nerve fibre
epineurium: around entire nerve
aggregations of cell bodies of neurons outside the CNS are called?