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Flashcards in Chemical Transmission CNS Deck (24):
1

3 CNS efferent

peripheral
somatic
autonomic

2

2 types of sensory afferent?

external stimuli
internal stimuli

3

name the NT and receptor type for sympathetic system

Noradrenaline - A/B (Ligand -gated) adrenoreceptors

4

name the NT and receptor type for parasympathetic system

ACh: muscarinic receptors(GPCR)

5

Inactivation usually occurs how with NA and ACh?

NA: reuptake
ACh: metabolism

6

2 kinds of receptors at synapse

post-junctional
prejunctional

7

what causes release of NTs?

calcium influx

8

4 ways NA is inactivated:

1. pre neuronal uptake: primary
2. prejunctional -ve feedback
3. postjunctional extraneuronal uptake
4. Metabolism via MAO

9

Cocaine dose response of S. american indians vs western society

chewed/slow release
injected/rapid absorption

10

what does amphetamines and ephedrine do in the synapse?

displaces NA from storage vesicles even at low levels of neuronal activation

11

what does cocaine do in the synapse?

prevent NA reuptake

12

3 'other' classes of NTs?

Amino Acids (GABA, glutamate)
Peptides (opioids, NPY, CCK)
Nitric Oxide

13

Dopamine is precursor to what?

Noradrenaline

14

4 big functions of Dopamine:

movement
behaviour
dependence: pleasure
pituitary

15

cocaine block 3 NT uptake:

NA
dopamine
serotonin

16

why do you get dependence in cocaine?

dopaminergic action

17

what does cocaine block at higher levels?

Na+ channels

18

To manage Parkinson's you need to treat with what?

Multiple:
L-DOPA + peripheral DDC inhibitor
MAO inhibitor
dopamine receptor agonist
muscarinic receptor antagonists

19

to treat Huntington's:

GABA against Baclofen
dopamine antagonist

20

Can a synapse be both excitatory and inhibitory?

Nope, one or the other

21

Can a NT be both excitatory and inhibitory?

yes depends on receptor

22

2 kinds of receptors in CNS:

Ligand-gated: nicotinic/GABA A
GPCR: muscarinic, A/B adrenoceptors

23

supporting cells of CNS secrete what? role in disease?

neurotrophic factors
degenerative diseases may be loss of these supporting cells

24

2 big tenants in CNS chemical transmission:

1. more than one NT involved
2. one NT involved in many pathways