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Jason's Neuro Block > CNS Viruses > Flashcards

Flashcards in CNS Viruses Deck (38):
0

What is neurotropic virus?

can replicate in nerve cells

1

neuroinvasive virus?

can enter/infect CNS

2

neurovirulent virus?

can cause disease within nervous system

3

Myelitis is?

infection of spinal cord

4

encephalomyelitis

brain and spinal cord infected

5

primary vs. secondary encephalitis?

1. primary: direct viral infection
2. secondary: post-infectious via past viral infection

6

viral vs. bacterial meningitis?

viral less severe but more common

7

main cause of viral meningitis?

1. enteroviruses
2. mumps, varicella zoster, influenza, HIV, HSV1,2

8

most likely cause of most serious viral encephalitis?

HSV1(face),2 (genital)
Rabies
arboviruses
enteroviruses

9

post infectious encephalomyelitis? eg.?

inflamm and demyelination, no virus present, autoimmune, Guillan-Barre

10

Reye's Syndrome is? who? fatality? when took what med made it worse?

Kids, post infection with influenza/varicella/25% fatality, parents gave aspirin during initial fever

11

what is a late sequel to measles?

chronic demyelinating disease, takes 30 years

13

HIV can progress to?

AIDS encephalopathy, 50% develop dementia

14

How can viruses spread to CNS if there is the BBB?

travels via peripheral axon fibres to CNS

15

why aren't viruses killed when they are moving within nerves?

no class 1 molecules for immune system to recognize

16

Viruses traversing 2 nerves how?

viral progeny can cross synaptic junction

17

what 3 vessels in the brain can viruses enter via blood stream?

choroid plexus blood vessels
meningeal
cerebral

18

HSV and coronavirus can enter the brain how?

olfactory bulb

19

viruses replicate in 2 cells in the brain:

1. neurons: direct kill
2. oligodendrocytes

20

Rabies has to grow in nerve cells?

yes, obligatory

21

Rabies has envelope? so what?

Yes, budding from infected cells

22

Rabies hides from immun system?

Nope

23

Australian 'Rabies' is called?

Lyssavirus from bats

24

Rabies symptoms?

Aggression
thirst/terror drinking water
foaming at mouth

25

How long does it take rabies to get to CNS? what does that mean?

10-60 days
means you can vaccinate after you get bitten

26

Alpha herpes viruses are what 3 kinds?

HSV 1
HSV 2
Varicella Zoster

27

does herpes have to grow in nerves? what kind of DNA? envelope?

Yes
dsDNA
enveloped

28

primary infection of HSV 1 involves? spread how?

mouth/throat
spread via saliva

29

What is most common cause of severe sporadic encephalitis?

HSV

30

Varicella Zoster latent phase hides where?

dorsal root ganglia

31

Polio: has to grow in nerves? envelope?

Not obligatory nerve growth
no envelope

32

polio kills it host?

yes, cytocidal

33

what kind of virus is polio?

enterovirus

34

what does low neuroinvasiveness mean?

hardly gets into CNS

35

why does polio cause paralysis?

invades spinal cord anterior horn cells

36

polio vector?

faecal-oral

37

what happens if polio paralyzes lungs?

Will die unless they are in iron lung

38

What other enteriovirus besides polio can cause meningitis? how spread?

Coxsackie B, A, echo viruses
fecal-oral spread