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Jason's Neuro Block > Pathogenesis of Dementia > Flashcards

Flashcards in Pathogenesis of Dementia Deck (19):
1

Neuro degen diseases associated with?

abnormal protein conformations

2

Alzheimer's genetic risk found on which chromosome?

chromosome 21 (APP mutations)

3

Alzheimer's risk ____ with each decade after 50?

doubles

4

4 types of Alzheimer's disease?

1. amnestic (temporal)
2. visuospatial (R>L)
3. aphasic (L>R)
4. frontal

5

what happens to aberrant Abeta monomers?

aggregate to become Amyloid Plaques + inflammation = neuron death

6

Where do the Abeta monomers/oligomers aggregate?

extra/intra synaptic sites and surfaces of neurons

7

what is the metal-protein attenuating compound targeting in Alzheimer's?

Abeta oligomers

8

how to scan for Abeta plaques?

inject carbon 11-PIB to stick to amyloids and PET scan

9

Alzheimer's on average takes how long to cause death?

30 years

10

spongiform encephalopathy causes death in how long?

6 months!

11

CJD odds?

1:1000 000

12

CJD is an infectious?

protein

13

CJD causes what in the brain?

fluid filled holes in the brain

14

what is PrPc and PrPres?

PrPres is resistant to degradation and insoluble

15

polymorphism where will determine susceptibility to PrPres?

M129 aka Methionine 129

16

vCJD into lymph nodes, implications?

circulating in blood stream, risk of blood transmission

17

incubation period for vCJD in blood?

6-15 years

18

Parkinson's protein misfold?

a-synuclein

19

Parkinson's a-synuclein leads to formation of what?

Lewy Bodies