Block 70,71: Endocrine Flashcards Preview

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Flashcards in Block 70,71: Endocrine Deck (54)
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1

chronic weakness, weight loss, hyponatremia, hyperkalemia with low-normal cortisol level

primary adrenal insufficiency (addison disease)

2

initial evaluation for Addison disease

8 AM serum cortisol
plasma ACTH

ACTH stimulation test is faster (cosyntropin test)

3

Lab values for Eurthroid sick syndrome

Low in total and free T3 levels
normal T4 and TSH

4

Riedel's (fibrous) thyroiditits

inflammatory disorder
- fibrosclerosis of thyroid and non thyroid structures

5

patient has UTI that is treated. comes back days later and has dark urine. with urine sample stains positive with Prussian blue

glucose-6-phosphate dehydrogenase deficiency

6

a positive Prussian blue stain indicates what in urine

hemosiderin

7

Heinz bodies

G6PD

8

Most common cause of primary adrenal insufficiency in developed countires

autoimmune adrenalitis

9

what is the difference between primary adrenal insufficiency and central adrenal insufficiency

PAI: hyperpigmentation and hyperkalemia

10

Difference between follicular thyroid cancer and benign follicular adenomas

FTCL invasion of tumor capsule and/or blood vessels. Hematogenous spread to distant tissues

11

hyperosmolar hyperglycemic state in type 2 diabetes mellitus

severe hyperglycemia and hyperosmolality
altered sensorium

12

characterize corticosteroid-induced psychosis

delusions, hallucinations

13

weight loss, tachycardia with proptosis and impaired extraocular motion

graves ophthalmopathy

14

Graves disease

TSH receptor antibody

15

what causes Graves ophthalmopathy

T cell activation and stimulation of orbital fibroblasts by TSH receptor autoantibdoies

16

Type 1 multiple endocrine neoplasia

- primary hyperparathyroidsim
- pituitary tumors
- GI/pancreatic endocrime tumors

17

glucagonoma

hyperglycemia
necrolyic migratory erythema
weight loss
anemia

18

cause of hypocalcemia in alcoholics ? explain phosphorus levels

hypomagnesemia
- decreases PTH release, but Phosphorus levels are not elevated

19

what causes graves Ophthalmopathy

activated t cells and thyrotropin receptor antibodies on TSH receptors

20

what treatment can worsen graves ophthalmopathy

radioactive treatment
- raise thyrotropin receptor antibodies

21

treatment for macroprolactinoma ( 1cm greater) or symptomatic prolactinoma

Dopaminergic agonists
Cabergoline, bromocriptine

22

presenting signs of glucagonoma

- mild diabetes or hyperglycemia
- necrotic migratory erythema

23

most beneficial therapy to reduce progression of diabetic nephropathy is

blood pressure control
130/80 goal

24

what percent is normal saline

.9%

25

oral estrogen preparations increase levels of what? what happens when you are on thyroid replacement

thyroxine-binding globulin
- higher dose of thyroid

26

acute thyrotoxicosis with mild thyroid gland enlargement and suppressed TSH

painless thyroiditis

27

thyroid scintigraphy for painless thyroiditis shows

decreased radioiodine uptake

28

Is thyroid enlarged in struma ovarii

no

29

is thyroid enlarged in painless thyroiditis

yes

30

pseudodemantia

major depression in elderly