Cancer chemotherapy

Question 1

form covalent bonds with nucleophilic substances

Answer 1

Alkylating agents

Question 2

nitrogen mustard

Answer 2

alkylating agent

Question 3

nitrosourea

Answer 3

alkylating agent

Question 4

platinum compounds

Answer 4

alkylating agent

Question 5

cisplatin

Answer 5

platinum based alkylating agent

Question 6

cyclophosphamide

Answer 6

nitrogen mustard alkylating agent

Question 7

lomustine, carmustine

Answer 7

nitrosoureas

effective against brain tumours due to ability to cross BBB

Question 8

Busulphan

Answer 8

chronic granulocytic leukaemia aka chronic myeloid leukaemia

Question 9

methotrexate

Answer 9

antifolate (antimetabolite)

Question 10

gemcitabine

Answer 10

antipyramidine (antimetabolite)

Question 11

antipurine

Answer 11

mecaptopurine, thioguanine

antimetabolite

Question 12

fludarabine

Answer 12

antipurine

inhibits DNA polymerase

Question 13

doxorubicin

Answer 13

anticancer anthracycline antibiotic

Question 14

daunorubicin, idarubicin, epirubicin, aclarubicin, and mitoxantrone (mitozantrone

Answer 14

anthracycline

affects topoisomerase 2

Question 15

Dactinomycin

Answer 15

Cytotoxic antibiotic

interferes with RNA polymerase

Question 16

Bleomycin

Answer 16

Cytotoxic antibiotic

metal-chelating glycopeptide antibiotic

Question 17

Mitomycin

Answer 17

Cytotoxic antibiotic

bifunctional alkylating agent

Question 18

Vincristine, vinblastine

Answer 18

Vinca alkaloids (plant derivatives)

Question 19

Paclitaxcel (taxol), docetaxel

Answer 19

Taxanes

plant derivatives

Question 20

irinotecan

Answer 20

Camptothecins

plant derivatives

Question 21

Etoposide

Answer 21

plant derivative

inhibits mitochondria, nucleoside transport and topoisomerase 2

Question 22

tamoxifen

Answer 22

Hormone antagonist used in breast cancer

Question 23

Procarbazine

Answer 23

inhibits DNA and RNA synthesis and interferes with mitosis

Question 24

Hydroxycarbamide

Answer 24

inhibits ribonucleotide reductase

Question 25

Crisantaspase

Answer 25

active against acute lymphoblastic leukaemia cells

Question 26

Amsacrine

Answer 26

topoisomerase II

Question 27

Mitotane

Answer 27

stops synthesis of adrenocortical steroids

Question 28

what are the 4 classes of plant derivatives

Answer 28

vinca alkaloids taxanes camptothecins etoposide

Question 29

vinca alkaloids

Answer 29

bind tubulin

Question 30

taxans

Answer 30

stabilises microtubules

Question 31

camptothecins

Answer 31

bind to and inhibit topoisomerase 1

Question 32

etoposide

Answer 32

inhibits mitochondrial function and topoisomerase 2