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Flashcards in sepsis Deck (15)
1

what is sepsis

severe infection where the body's response to infection injures it's own tissues and organs

deregulated inflammation following infection

2

what is severe sepsis

life threatening sepsis
vital organ failure and are ill enough to go to ICU

3

what is severe sepsis characterised by

inflammation
vasodilation
leukocytaemia
microvascular permeability
organ/system failure

4

how can you recognise severe sepsis

arterial hypotension
blood lactate >2
impaired gas exchange
diminished responsiveness or confusion

5

how is septic shock defined

arterial hypotension for at least one hour despite fluids
serum lactate >4mmol/L after fluids

a type of distributive shock where abnormal blood flow results in inadequate tissue supply

6

what is SIRS

temperature 38
HR >110
resp rate >25
WBCs >11 or >4 x10 -3

affects organs and leads to multiple organ failure

also used for burns, trauma, pancreatitis and other non infectious illnesses

7

what organ systems should be monitored

CV
resp
neuro
renal
coagulation
hepatic

8

what is MODS

multiple organ dysfunction syndrome

9

what are toll like receptors

surface receptors in the innate immune system

10

what effect do TLRs have

increased blood flow
cortisol, oestrogen and adrenaline
platelet activation
increased metabolism
increased mitochondrial activity

11

what can explain organ function recovery after sepsis

mt adopt low energy state

12

what are the risk factors for sepsis

malignancy
Age > 65
immunocompromised
dialysis
alcoholism
diabetes
chronic kidney disease

13

what is the sepsis 6

monitor urine
antibiotics
fluid resus
oxygen
blood lactate
cultures

14

what are the 3 levels of wards

ward
high dependency unit
intensive therapy unit

15

what are the principles of treatment

early recognition
early stratification
specific goals in mind
early antibiotics
triage of care
sbar handover