Chapter 22: The Lymphatic System and Immunity Flashcards

(61 cards)

1
Q

the primary responsibilities of the lymphocytes in the lymphatic system are to respond to the presence of…

A
  1. invading pathogens
  2. abnormal body cells
  3. foreign particles
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2
Q

the anatomical barriers and defense mechanism that cannot distinguish one potential threat from another are called…

A

innate (nonspecific) defenses

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3
Q

the major components of the lymphatic system include…

A

lymphatic vessels, lymph, and lymphoid organs

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4
Q

lymphoid organs found in the lymphatic system include…

A

spleen, thymus, and lymph nodes

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5
Q

the primary function of the lymphatic system is…

A

production, maintenance, and distribution of lymphocytes

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6
Q

lymphocytes that assist in the regulation and coordination of the immune response are…

A

helper T and suppressor T cells

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7
Q

normal lymphocyte populations are maintained through lymphopoiesis in the…

A

red bone marrow and lymphatic tissues

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8
Q

the largest collection of lymphoid tissue in the body is contained within the…

A

adult spleen

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9
Q

the reticular epithelial cells in the cortex of the thymus maintain the blood-thymus barrier and secrete the hormones that…

A

stimulate stem cell divisions and T-cell differentiation

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10
Q

what includes only innate defenses?

A

hair, skin, complement, inflammation, phagocytosis

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11
Q

the protective categories that prevent the approach of, deny entrance to, or limit the spread of microorganism or other environmental hazards are called…

A

nonspecific defenses

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12
Q

natural killer cells sensitive to the presence of abnormal cell membranes are primarily involved with….

A

immunological surveillance

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13
Q

a physical barrier such as the epithelial covering of the skin provides effective immunity due to its makeup, which includes…

A
  1. multiple layers
  2. a keratin coating
  3. a network of desmosomes that lock adjacent cells together
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14
Q

the “first line” of cellular defense against pathogenic invasion is…

A

phagocytes

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15
Q

redness, swelling, heat, and pain are signs and symptoms associated with…

A

the inflammatory response

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16
Q

the four general characteristics of adaptive defenses include…

A

specificity, versatility, memory, and tolerance

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17
Q

the two major ways that the body “carries out” the immune response are…

A

direct attack by T cells and attack by circulating antibodies

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18
Q

an adaptive defense mechanism is always activated by…

A

an antigen

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19
Q

the type of immunity that develops as a result of natural exposure to an antigen in the environment is…

A

naturally acquired active immunity

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20
Q

a vaccine is an example of….

A

artificially induced active immunity

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21
Q

when an antigen appears, the immune response begins with the…

A

activation of specific T cells and B cells

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22
Q

if immune tolerance malfunctions in an individual, his or her B cells might begin to…

A

manufacture antibodies against “self” cells and tissues

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23
Q

T-cell activation leads to the formation of cytotoxic T cells and memory T cells that provide…

A

cellular immunity

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24
Q

before an antigen can stimulate a lymphocyte, it must first be process by a…

A

macrophage

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25
CD8 T cells are activated by exposure to antigens bound to...
Class I MHC proteins
26
The T cells that limit the degree of immune system activation from a single stimulus are...
suppressor T cells
27
since each kind of B cell carries its own particular antibody molecule in its cell membrane, activation can only occur in the presence of a...
corresponding antigen
28
activated B cells produce plasma cells that are specialized because they...
synthesize and secret antibodies
29
an antibody is shaped like a....
Y
30
antigen binding changes antibody shape, exposing additional protein binding sites, which can lead to...
activation of the complement system
31
antibodies may promote inflammation through the stimulation of...
basophils and mast cells
32
the antigenic determinant site is that portion of the antigen's exposed surface where...
the antibody binds
33
in order for an antigenic molecule to be a complete antigen, it must...
have at least two antigenic determinant sites
34
the ability to demonstrate an immune response upon exposure to an antigen is called...
immunological competence
35
fetal antibody production is uncommon. Rather, the developing fetus has...
natural passive immunity
36
when an immune response mistakenly targets normal body cells and tissues, the result is...
an autoimmune disorder
37
depression of the immune system due to chronic stress may cause...
1. depression of the inflammatory response 2. a reduction in the activities and numbers of phagocytes in peripheral tissues 3. the inhibition of interleukin secretion
38
the effects of tumor necrosis factor in the body are to...
1. slow tumor growth and kill sensitive tumor cells 2. stimulate granulocyte production 3. increase T-cell sensitivity to interleukins
39
the major functions of interleukins in the immune system are to...
1. increase T-cell sensitivity to antigens exposed on macrophage membranes 2. stimulate B-cell activity, plasma-cell formation, and antibody production 3. enhance innate defenses
40
with advancing age, B cells are less responsive, causing a...
decreased antibody level after antigen exposure
41
the lymphatic system influences nervous system activity by...
releasing cytokines that affect hypothalamic production of CRH and TRH
42
the three different classes of lymphocytes in the blood are...
T cells, B cells, and NK cells
43
the primary effects of complement activation include...
1. destruction of target cells membranes 2. stimulation of inflammation 3. attraction of phagocytes and enhancement of phagocytosis
44
What best defines the lymphatic system?
a one-way route from the interstitial fluid to the blood
45
tissue fluid enters the lymphatic system via the...
lymph capillaries
46
the larger lymphatic vessels contain valves.
True
47
a localized tissue response to injury is...
the inflammatory response
48
chemical mediators of inflammation include...
histmaine, kinins, prostaglandins, and leukotrienes
49
T lymphocytes comprise approximately ___________ percent of circulating lymphocytes.
70-80
50
B lymphocytes differentiate into...
memory and plasma cells
51
___________ cells may activate B cells, whereas ___________ cells inhibit the activity of B cells.
helper T; suppressor T
52
the primary response of T-cell differentiation in cell-mediated immunity is the production of __________ cells.
cytotoxic T
53
the vaccination of antigenic materials into the body is called...
artificially acquired passive immunity
54
in passive immunity, ___________ are transferred from another source.
antibodies
55
the lymphatic function of the white pulp of the spleen is...
initiation of immune responses by B cells and T cells
56
a person with type AB blood has...
neither anti-A nor anti-B antibodies
57
the antibodies produced and secreted by B lymphocytes are soluble proteins called...
immunoglobulins
58
the genes found in a region called the major histocompatibility complex code for...
human leukocyte antigens (HLAs)
59
memory B cells do not differentiate into plasma cells unless they are...
exposed to the same antigen a second time
60
the three-dimensional "fit" between the variable segments of the antibody molecule and the corresponding antigenic determinant is referred to as the...
antibody-antigen complex
61
one of the primary nonspecific effects that glucocorticoids have on the immune response is...
depression of the inflammatory response