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Flashcards in Diabetes Insipidus Deck (12):
1

What issue occurs that results in DI?

Deficiency/decreased response to ADH

2

In Nephrogenic DI what occurs?

The kidneys do not respond to ADH

3

What are some reasons why the kidneys in Nephrogenic DI are not responsive to ADH?

Genetic trait affecting the V2 receptor that affects ADH receptor on the distal tubule
Drugs like lithium
Electrolyte imbalances

4

In central DI, what two subcategories are there?

Partial - insifficient amount of ADH
Complete - no ADH at all

5

In central DI what is the issue that brings about DI?

A defect in the synthesis or release of ADH

6

What are things that may cause central DI?

Head injury
Or surgery near the hypothalamus or posterior pituitary

7

What is the patho for central DI?

Loss of 80-90% of ADH secreting neurons -> polyuria

8

What are mnft of DI?

Polyuria
Excessive thirst

9

Which type of DI can maintain near normal water balance if they gave access to water when thirsty?

Partial Cdi

10

How is DI diagnosed?

24 hour output
MRI
measurement of ADH serum levels

11

What is the treatment for DI?

Thiazide diuretics
Desmopressin acetate

12

What two types of DI are there?

Neurogenic/central
Nephrogenic