Myasthena Gravis Flashcards Preview

252 > Myasthena Gravis > Flashcards

Flashcards in Myasthena Gravis Deck (10):
1

What does myasthenia gravis affect

Communication between the motor neuron and the inner cared muscle cells

2

What is the etiology of myasthenia gravis?

Autoimmunity with an unknown trigger
Possible sensitized T cells

3

What is the patho of myasthenia gravis?

Autoimmunity abs target acetylcholine receptors and bind to them -> less acetylcholine is binding -> muscle weakness and weakened contractions due to less acetylcholine actions

4

Many people with myasthenia gravis also have an abnormal what?

Thymus due to hyperplasia or tumor (large thymus)

5

How is myasthenia gravis diagnosed?

Hx
Px
Anticholinesterase test
Nerve stimulation
Assay for ach receptor antibodies

6

How is myasthenia gravis treated?

Reversible anticholinesterase drugs
Immunosuppressive therapy
Plasmapheresis

7

What is the myasthenic crisis?

Sudden worsening of symptoms and weakness severe enough to compromise ventilation

8

When does the myasthenic crisis usually occur?

During a period of stress

9

What are mnft of myasthenia gravis ?

Eye muscle weakness
Unstable gait
Difficulty speaking (dysarthria)
Weakness in arms hands legs fingers and neck

10

What is myasthenia gravis?

Autoimmune disorder affecting transmission at neuromuscular junction