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Flashcards in Neurological Disorders - ALS Deck (25):
1

What neurons does ALS affect?

Motor neurons

2

What do people with als often die from?

Respiratory failure

3

What are two other names for ALS?

Lougherigs and charcots

4

What three forms of ALS are there?

Sporadic
Familial
Other factors

5

How prevalent is the sporadic form of ALS and what are the two causes of it?

90-95%.
The SOD1 gene
Superoxide dimutase gene - mutation allows superoxide free radicals to accumulate and damage cells

6

What genes are involved in the familial etiology of ALS?

Sod1 gene and others

7

What other factors may contribute as an etiology to ALS?

Autoimmune

8

What is the patho of ALS? What is proposed as another patho for ALS?

Motor neurons are degenerated in: anterior horn cells in spinal cord, motor nuclei in brain stem and upper motor neurons in cerebral cortex

Free radical and or glutamate toxicity which results in damage to motor neurons

9

Where do upper motor neurons run from?

Brain to spinal cord

10

What are manifestations of ALS?

Muscle atrophy (because the muscle is receiving inadequate stimulation therefore person does not use)
Weakness
Fascicultations (spontaneous twitch)
Dysarthria (impaired speech)

11

What are the acute complications of ALS?

Dysphasia and aspiration

12

What remains intact in ALS?

Cognition and sensory function

13

How is ALS diagnosed?

Clinical presentation
Electromyography

14

What is the treatment for ALS?

Supporting management
Riluloze (neuro protective drug that addresses glutamate toxicity)

15

What three forms of ALS are there?

Sporadic
Familial
Other factors

16

How prevalent is the sporadic form of ALS and what are the two causes of it?

90-95%.
Superoxide dimutase gene (SOD1) - mutation allows superoxide free radicals to accumulate and damage cells

17

What genes are involved in the familial etiology of ALS?

Sod1 gene and others

18

What other factors may contribute as an etiology to ALS?

Autoimmune

19

What is the patho of ALS? What is proposed as another patho for ALS?

Motor neurons are degenerated in: anterior horn cells in spinal cord, motor nuclei in brain stem and upper motor neurons in cerebral cortex

Free radical and or glutamate toxicity which results in damage to motor neurons

20

Where do upper motor neurons run from?

Brain to spinal cord

21

What are manifestations of ALS?

Muscle atrophy (because the muscle is receiving inadequate stimulation therefore person does not use)
Weakness
Fascicultations (spontaneous twitch)
Dysarthria (impaired speech)

22

What are the acute complications of ALS?

Dysphasia and aspiration

23

What remains intact in ALS?

Cognition and sensory function

24

How is ALS diagnosed?

Clinical presentation
Electromyography

25

What is the treatment for ALS?

Supporting management
Riluloze (neuro protective drug that addresses glutamate toxicity)