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Flashcards in Guillain-Barre Syndrome Deck (12):
1

Where is the autoimmunity targeting in GB syndrome?

The PNS

2

Does GB usually go away?

Yes within around 6-12 months. That is why it is not tradition autoimmunity because traditional autoimmunity is lifelong

3

What is the etiology of GB syndrome?

Idiopathic - truly autoimmune but not of the traditional type

4

What GB preceded by about 1-4 weeks before autoimmunity starts?

Preceded by URT (viral infection usually EBV) or GI (bacterial infection usually compylobacter jejuni)

5

What is the patho of GB syndrome?

Abs and T cells target myelin sheaths in PNS -> damage of Schwann cells -> inflammation and damage -> loss of conduction

6

What are the manifestation of GB syndrome?

Signs of infection from URT or GI (if still present when autoimmunity starts)
Parasthesias (numbness and tingling) that turns into muscle weakness and then paralysis

7

What is unique about the progression of manifestations of GB syndrome?

The parasthesias start in the feet and then move in ascending order up the body. When the manifestations begin to go away they go away in descending order.

8

When parasthesias from GB syndrome pass either the hips or shoulders what is experienced?

Deep muscle pain

9

What is the main cause of death from GB syndrome?

Respiratory failure

10

How is GB syndrome diagnosed?(4)

Hx
Px (neuro & musculoskeletal exam to determine whether it is a neural, muscular or neuromuscular issue)
Weak tendon reflexes
Decreased nerve conduction
CSF analysis - slightly elevated proteins as innervation for PNS is at spinal cord

11

What is the treatment for GB syndrome?(4)

Preserve life
Plasmapheresis
IV IgG (immunoglobulins)
Pain meds

12

What is GB syndrome?

Untraditional autoimmunity that results in general paralysis