Liver Flashcards
(34 cards)
Hepatic portal vein: blood going where
From other gi organs to liver
Hepatic veins: blood going where
Blood leaving liver
Blood flow sources and % to liver
Hepatic portal vein 80%, hepatic artery 20%
Bile: charged what. Bound to what. How much is recycled and made new. Liver needs what to make new bile.
Negative. H or Na (acid or salt). 90%. 10%. Cholesterol
Phases of RBC destruction/bilirubin excretion: 5
___ to ___
To __ __
Liver ___ and adds ___ __, now soluble in what
___ excreted with ___
Heme to biliverdin (green bruise)
To unconjugated bilirubin (lipid soluble, binds albumin)
Liver conjugates and adds glucaronic acid (water soluble)
Conjugated excreted with bile, dark color
Liver makes how much of daily lymph production
50%
Space of disse: what happens here
Fluid here becomes lymph
Blood flows from __ __ to __ __ down __ __
Portal triad, central vein, sinusoidal capillaries
Basic unit of the liver. Drained by what.
Lobule. Central vein
Portal triad composed of what (4)
Hepatic portal vein, hepatic artery, bile duct, lymphatic vessel
Sinusoids: blood flows from __ region, to __ of ___, to ___ region.
Blood flow here is what.
Perilobular, space of disse, centrolobular
Takes 10x longer than rest of capillary
Blood becomes __ __ as head down sinusoid towards central vein. As this happens cells become __ __ active
Less oxygenated, less metabolically
High or low for each category:
Perilobular region: oxygen, hormones, glycolysis enzymes
High, high, low
High or low
Perilobular region: glucose liberating enzymes, fatty acid oxidation enzymes, fatty acid synthesizing enzymes
High, high, low
High or low
Centrolobular region: oxygen, hormones, glycolysis enzymes
Low, low, high
High or low
Centrolobular region: glucose liberating enzymes, fatty acid oxidation enzymes, fatty acid synthesizing enzymes
Low, low, high
Bile travels from __ of hexagon (___) to ___ ___ where its drained
Center, lobule, outside corners
Bile path:
- down ___ duct. 2. Up the __ duct into __ where it waits
- __ at meal time when contraction 4. Down __ duct
- Into __ __ duct 6. Exits __ of __ into __
- Hepatic 2. Cystic, gallbladder
- Released 4. Cystic
- Common bile
- Sphincter of oddi, duodenum
Bile cannaliculi: what it is, where it is, what it does
Space between two hepatocytes with zonula occludens. Creates space to drain waste
Bile duct lined with what, what it gives off
Bile duct cells, GGT
Overall flow of blood In from \_\_ \_\_ \_\_ and \_\_ \_\_, to \_\_ \_\_ region to \_\_\_ of \_\_, To \_\_ \_\_ region, to \_\_ \_\_ Out through \_\_ \_\_
Hepatic portal vein and hepatic artery Sinusoids/perilobular region Space of disse Sinusoid centrolobular region, central vein Hepatic vein
Carbohydrate metabolism: stores \_\_\_. Converts \_\_\_ and \_\_ to \_\_ \_\_\_\_\_ Form \_\_ \_\_ from intermediate products of carb metabolism
Glycogen
Galactose and fructose to glucose
Gluconeogenesis
Chemical compounds
Protein metabolism \_\_\_ of amino acids Forms \_\_\_ for removal of ammonia Forms \_\_ \_\_ \_\_\_
Deamination
Urea
Plasma proteins
Transamination
Fat metabolism Oxidation of fatty acids to do what Synthesis of \_\_, \_\_, and \_\_\_ Synthesis of fat from \_\_ and \_\_ CANT make \_\_ into \_\_or \_\_
Make ketones, supply energy for other functions
Cholesterol, phospholipids, lipoproteins
Protein and carbs
Fat cant become protein or carbs
