Liver Flashcards Preview

Physiology > Liver > Flashcards

Flashcards in Liver Deck (34):
1

Hepatic portal vein: blood going where

From other gi organs to liver

2

Hepatic veins: blood going where

Blood leaving liver

3

Blood flow sources and % to liver

Hepatic portal vein 80%, hepatic artery 20%

4

Bile: charged what. Bound to what. How much is recycled and made new. Liver needs what to make new bile.

Negative. H or Na (acid or salt). 90%. 10%. Cholesterol

5

Phases of RBC destruction/bilirubin excretion: 5
___ to ___
To __ __
Liver ___ and adds ___ __, now soluble in what
___ excreted with ___

Heme to biliverdin (green bruise)
To unconjugated bilirubin (lipid soluble, binds albumin)
Liver conjugates and adds glucaronic acid (water soluble)
Conjugated excreted with bile, dark color

6

Liver makes how much of daily lymph production

50%

7

Space of disse: what happens here

Fluid here becomes lymph

8

Blood flows from __ __ to __ __ down __ __

Portal triad, central vein, sinusoidal capillaries

9

Basic unit of the liver. Drained by what.

Lobule. Central vein

10

Portal triad composed of what (4)

Hepatic portal vein, hepatic artery, bile duct, lymphatic vessel

11

Sinusoids: blood flows from __ region, to __ of ___, to ___ region.

Blood flow here is what.

Perilobular, space of disse, centrolobular

Takes 10x longer than rest of capillary

12

Blood becomes __ __ as head down sinusoid towards central vein. As this happens cells become __ __ active

Less oxygenated, less metabolically

13

High or low for each category:
Perilobular region: oxygen, hormones, glycolysis enzymes

High, high, low

14

High or low
Perilobular region: glucose liberating enzymes, fatty acid oxidation enzymes, fatty acid synthesizing enzymes

High, high, low

15

High or low
Centrolobular region: oxygen, hormones, glycolysis enzymes

Low, low, high

16

High or low
Centrolobular region: glucose liberating enzymes, fatty acid oxidation enzymes, fatty acid synthesizing enzymes

Low, low, high

17

Bile travels from __ of hexagon (___) to ___ ___ where its drained

Center, lobule, outside corners

18

Bile path:
1. down ___ duct. 2. Up the __ duct into __ where it waits
3. __ at meal time when contraction 4. Down __ duct
5. Into __ __ duct 6. Exits __ of __ into __

1. Hepatic 2. Cystic, gallbladder
3.Released 4. Cystic
5. Common bile
6. Sphincter of oddi, duodenum

19

Bile cannaliculi: what it is, where it is, what it does

Space between two hepatocytes with zonula occludens. Creates space to drain waste

20

Bile duct lined with what, what it gives off

Bile duct cells, GGT

21

Overall flow of blood
In from __ __ __ and __ __,
to __ __ region to ___ of __,
To __ __ region, to __ __
Out through __ __

Hepatic portal vein and hepatic artery
Sinusoids/perilobular region
Space of disse
Sinusoid centrolobular region, central vein
Hepatic vein

22

Carbohydrate metabolism:
stores ___.
Converts ___ and __ to __
_____
Form __ __ from intermediate products of carb metabolism

Glycogen
Galactose and fructose to glucose
Gluconeogenesis
Chemical compounds

23

Protein metabolism
___ of amino acids
Forms ___ for removal of ammonia
Forms __ __
___

Deamination
Urea
Plasma proteins
Transamination

24

Fat metabolism
Oxidation of fatty acids to do what
Synthesis of __, __, and ___
Synthesis of fat from __ and __
CANT make __ into __or __

Make ketones, supply energy for other functions
Cholesterol, phospholipids, lipoproteins
Protein and carbs
Fat cant become protein or carbs

25

Other liver metabolic functions
Storage for vitamins __, __, and __
Storage of __ as __
__ factors
Remove or excrete __ or __

A, D, B12
Iron, ferritin
Coagulation
Drugs and hormones

26

Liver releases __ which joins __ from GI tract in capillaries, where lipoprotein lipase sucks out FA making it ___. Now this product is ___ which goes to __ or __

VLDL, chylomicrons
Smaller
LDL, liver or body

27

Cellular level
LDL receptor binds LDL particle, its __, __ breaks down particles to __ acids, __ acids, and __ __ which is released to cell

Endocytosed
Lysosome
Fatty, amino, cholesterol ester droplet

28

Endoplasmic reticulum makes __ __ to sit on outside of cell

LDL receptors

29

HDL binds excess __ from cells and returns it to __

Cholesterol, liver

30

Chylomicrons, VLDL, LDL, HDL
Density pattern
Fat pattern

Density Increases left to right
Fat decreases left to right

31

HDL is. Basically what

Empty bag

32

As fat is sucked out, lipoprotein particles get ___ but __ increases

Smaller, density

33

Two organs that dont drain to liver

Kidney and gonads

34

__, __, and __ drain to liver

Gallbladder, pancreas, spleen