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Flashcards in Liver Disease Deck (17):
1

what are some functions of the liver?

protein/carbohydrate/lipid/bile acid/bilirubin/hormone and drug metabolism
immunological defence

2

what is jaundice?

hyperbilirubineamia

3

what types of liver disease causing jaundice?

acute liver disease
chronic liver disease
jaundice secondary to biliary obstruction

4

what are some clinical features of jaundice?

jaundice
pale stools
dark urine conjugated bilirubin
itch
letharygy/malaise
anorexia
features of underlying disease

5

what goes wrong in jaundice?

increased production
failure of excretion - defective conjugation hepatocyte, defective delivery to cannulicus hepatocyte
blockage of bile ducts intra and or extra hepatic biliary tree

6

causes of jaundice? increased production?

haemolysis
ineffective erythropoiesis

7

what are causes of jaundice? congenital?

unconjugated - gilberts/crigler - najjar, conjugated - dubin johnson, rotor syndrome

8

intra hepatic causes of cholestatic jaundice?

viral hepatitis
drugs
aloholic hepatitis
cirrhosis
pregnancy
misc

9

extra hepatic causes of cholestatic jaundice?

gall stones in CBD
carcinoma
pancreatitis
biliary structure
scelorsing cholangitis

10

what are liver function tests?

ALT/AST
alkaline phosphatase
GGT

11

what are true liver function tests?

bilirubin
albumin
prothrombin time

12

how is hep a virus?

faecal oral spread
poor hygiene/overcrowding
food/water contamination causes large outbreaks
some cases imported

13

how to control hep a?

hygiene
pre exposure prophylaxis
post exposure prophylaxis

14

clinical features of hep a?

acute illness
manage with rest/low fat diet and alcohol avoidance

15

how is hep b transmitted?

blood
sex
mother to child

16

how to control hepatitis b transmission?

safe blood/sex/needle exchange
vaccinations
pep

17

hepatitis c infection results in what in 80% of cases?

chronic infection