Flashcards in Haematology Deck (57)
where is the cellular component of blood produced?
what does a full blood count measure?
number and size of cells
what is the condition associated with lack of haemoglobin?
cells that are too big are?
what is WCC?
quantity of white blood cells
too many white blood cells?
too few platelets?
what is a blood film test?
smear of red blood cells examined under a microscope
what is neutrophilia?
increase in neutrophil production caused by an acute infection
what is malaria?
red blood cells deteriorate because of parasites
how are bone marrow samples done?
taken from iliac crest/sternum
what are tests to measure coagulation?
activated prothrombin time APTT
what pathway causes APTT?
what is a normal prothrombin time?
reasons for lack of haemoglobin in anaemia?
lack of raw materials
what raw materials are needed for haemoglobin to form?
iron, vit B12, folate
why might there be a lack of iron and folic acid?
usually dietary, rarely malabsorption
increase in lack of when pregnant
lack of vit b12 caused by?
what kind of anaemia does it cause?
autoimmune diseases affect absorption of B12
what do you see on a blood film of someone with anaemia?
very pale cells = hypochromic
micocytic smaller cells
why might there be production problems to do with erythropoiten?
reasons for production problems do to with bone marrow ?
aplastic anaemia - no cells
anaemia of chronic disease - any chronic inflam process
what are reasons for blood loss causing lack of haemoglobin?
bowel - majority
other organs - unusual
wjhat is haemolysis?
destruction of cells in circulation
e.g autoimmunity, sickle cell anaemia, thalassemia
lack of what raw materials cause macorcytic cells?
B12, folate deficiency
what are some symptoms of anaemia?
tired, weak, breathless, dizzy, palpitations
signs of anaemia?
pale, rapid pulse, oral feautres
management of anaemia?
history and exam
establish type - fbc, blood film, levels of iron, folate, b12
treatment of anaemia?
iron sulphate folic acid, B12
severe/symptomatic - blood transfusion
dental - oral abnormalities caused by?
why be careful with GA?
what should you verify in an anaemic pt?
iron, b12, folate
o2 capacity reduced,
sickle cell status
what is a neutropenia? caused by?
an inadequate number of neutrophils
bone marrow failure, auntoimmune disease