Overview of the Pulmonary System/Lung Development Flashcards Preview

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Flashcards in Overview of the Pulmonary System/Lung Development Deck (56)
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1

When does surfactant begin to be made in the lungs?

gestational month 6-7

1

Name the contributors to pulmonary work of breathing.

1. increased elastic properties of the lungs

2. resistance to flow in the airways

3. impaired gas exchange

2

Obstructive disease means _____; restrictive disease means ______.

you can't get air out; you can't get air in

3

What is the substance that lowers alveolar surface tension?

surfactant

4

Deadspace refers to parts of the lung that ______.

do not exchange gas

4

The ______ develops from the surrounding mesenchyme.

pulmonary circulation

4

What are the key features of the canalicular phase?

  • 17-26 weeks gestation
  • 1a development of pulm capillary bed
  • expansion of airspace into mesenchyme
  • fetal breathing detected
  • epi cell differentiation begins
  • possible to survive but respiratory distress

5

The overlapping stages in embryogenesis of the lung include the initial branching, called the embryonic phase (26 days to 6 weeks gestation), the pseudoglandular phase lasting through 16 weeks where ____ more rounds of branching to the terminal bronchioles occurs, and the cannicular phase where the terminal bronchioles branch into _______ (to age 28 weeks).

14; respiratory bronchioles

6

The first ____ airways are conducting airways; the rest are transitional and respiratory.

16

6

What is a normal, healthy FEV1?

70-80%

7

What are the key features of the saccular phase?

  • 26-36 weeks gestation
  • distal growth and branching of term sacs
  • thinning of interstitial space
  • decrease in cell prolif
  • epi cells are differentiated into Type I and II

8

Name the phase.

  • 17-26 weeks gestation
  • 1a development of pulm capillary bed
  • expansion of airspace into mesenchyme
  • fetal breathing detected
  • epi cell differentiation begins
  • possible to survive but respiratory distress

canalicular phase

9

Where do the pulmonary arteries originate?

the 6th aortic arch

10

Gas-exchange occurs at ______.

the capillary-alveolar interface

11

Lymphatics run near ______ to help cope with extravascular lung water.

the pulmonary arteries and veins

12

The overlapping stages in embryogenesis of the lung include the initial branching, called the _______ (26 days to 6 weeks gestation), the _______ lasting through 16 weeks where 14 more rounds of branching to the terminal bronchioles occurs, and the _______ where the terminal bronchioles branch into respiratory bronchioles (to age 28 weeks).

embryonic phase pseudoglandular phase cannicular phase

12

The lung bud develops ventrally into the mesoderm at _______.

week 4

12

What does FEV1 stand for? What does it mean?

it's the percentage of your vital capacity that you can exhale in 1 sec

13

_____ have two primary functions: 1) to repair or replace injured Type I pneumocytes, and 2) to secrete surfactant, a substance which lowers alveolar surface tension.

Type II cells

14

Name the phase.

  • 26-36 weeks gestation
  • distal growth and branching of term sacs
  • thinning of interstitial space
  • decrease in cell prolif
  • epi cells are differentiated into Type I and II

saccular phase

16

Since the conducting airways by definition do not exchange gas, they are known as "______."

anatomic deadspace

17

What is ventilation?

movement of air into/out of the lungs

19

Movement of the lungs within the thoracic cavity during inspiration and expiration is facilitated by a space between the two structures called _______.

the pleural space

19

_____ represents the transition from bronchi to bronchioles.

Loss of cartilage in the outer tissue layer

19

The lung bud develops _____ into the ______ at week 4.

ventrally; mesoderm

21

Surfactant is an _____ molecule.

amphipathic

23

The lungs develop from ______.

the lung bud of the gut tube endoderm

24

Type 1 pneumocytes are comprised of _____ cells.

simple squamous

25

_______ develop from the lung bud of the gut tube endoderm.

The lungs

26

Type II cells have two primary functions: 1) _______, and 2) to secrete surfactant, a substance which lowers alveolar surface tension.

to repair or replace injured Type I pneumocytes