Restrictive/Inflammatory Lung Disease Flashcards Preview

CVPR Pulmonary (Exam 3) > Restrictive/Inflammatory Lung Disease > Flashcards

Flashcards in Restrictive/Inflammatory Lung Disease Deck (23):
1

In restrictive lung diseases, the compliance is ____ and the airway resistance is ____.

compliance = decreased (more stiff)
resistance = decreased

2

A decrease in lung compliance can occur via which 3 mechanisms?

1. Increased thickness of the lung interstitium
2. Increased lung water
3. Increased alveolar surface tension

3

How does the thickness of the lung interstitium become increased?

increased deposition of elastic/connective tissue in chronic interstitial lung disease or lung injury

4

Increased lung water is most commonly seen with ____.

congestive heart failure

5

Increases in alveolar surface tension tend to cause _____ which reduces compliance.

alveolar collapse

6

What causes ARDS?

lung injury to the type II alveolar cells

7

The PV curve is _____ in restrictive lung dz.

flatter and shifted down

8

______ are usually the earliest manifestation of interstitial lung disease.

Symptoms with exercise

9

DLCO is ______ in restrictive disease.

decreased

10

Name 4 known causes of interstitial lung disease (ILD).

1. Autoimmune disease
2. Exposure to inorganic dusts (typically occupational dusts such as silica or
asbestos)
3. Exposure to organic molecules that result in hypersensitivity pneumonitis
4. Drug effect

11

What can cause idiopathic ILD?

sarcoidosis and the idiopathic interstitial pneumonias
(IIPs)

12

The presentation of most forms of ILD is the insidious onset of ______.

dyspnea on exertion

13

Therapy for many forms of ILD involves ______.

immunosuppression

14

Pulmonary fibrosis is a generic term that refers to ______.

lung scarring

15

_____ is a systemic granulomatous disease of unknown etiology that is characterized pathologically by noncaseating granulomas.

Sarcoid

16

Sarcoid is a systemic granulomatous disease of unknown etiology that is characterized pathologically by _______.

noncaseating granulomas

17

What is a granuloma?

compact collections of macrophages and epithelioid cells surrounded by lymphocytes

18

This is a compact collection of macrophages and epithelioid cells surrounded by lymphocytes.

a granuloma

19

What do granulomas often secrete? What does this cause?

calcitriol; hypercalcemia

20

What is Lofgren’s syndrome?

1. Inflammatory arthritis
2. Erythema nodosum
3. Bilateral hilar lymphadenopathy

21

Dx?
1. Inflammatory arthritis
2. Erythema nodosum
3. Bilateral hilar lymphadenopathy

Lofgren’s syndrome

22

What is the tx for Lofgren’s syndrome?

none, it's self limiting

23

What is the tx for sarcoidosis?

usually none, but can use corticosteroids or other cytotoxic drugs (e.g. methotrexate)