Pathoma: Lung CA Flashcards Preview

CVPR Pulmonary (Exam 3) > Pathoma: Lung CA > Flashcards

Flashcards in Pathoma: Lung CA Deck (56):
1

This is a tumor that lacks glands, mucus production (adenocarcinoma), keratin pearls, or intercellular bridges (squamous cell carcinoma).

large cell carcinoma

2

  • adenocarcinoma (40%)
  • squamous cell carcinoma (30%)
  • large cell carcinoma (10%)
  • carcinoid tumor (5%)

--> All are types of?

non-small cell carcinoma

2

Where is bronchioloalveolar carcinoma typically found? Related to smoking? Prognosis?

  • peripherally located
  • not related to smoking
  • excellent prognosis

3

What are the 4 subtypes of non-small cell carcinoma?

  • adenocarcinoma (40%)
  • squamous cell carcinoma (30%)
  • large cell carcinoma (10%)
  • carcinoid tumor (5%)

3

What is the overall 5-year survival rate of lung CA?

15%

4

If the lung tumor starts with _____, it is highly associated with smoking and paraneoplastic syndrome, and is centrally located.

S

4

Compression of _____ by lung CA causes ptosis, pinpoint pupils, and anhidrosis.

the sympathetic chain

4

What is a Pancos tumor?

a tumor in the apex of the lung

6

What are the 3 most common cancers in the US by incidence rate?

1. breast/prostate 2. lung 3. colorectal

6

Name 2 benign lesions that can look like lung CA on chest xray.

  1. granuloma
  2. bronchial hamartoma

6

If the lung tumor starts with an S, it is highly associated with _____.

smoking and paraneoplastic syndrome, and is centrally located

7

_____ of the lung may produce PTHrP hormone, causing hypercalcemia.

Squamous cell carcinoma

8

What is a squamous cell carcinoma?

tumor consisting of keratin pearls or intercellular bridges

8

If a lung tumor involved the ____ nerve, the pt would present with hoarseness.

recurrent laryngeal

9

_____ is usually treated with chemo and not surgery, but _____ is treated by resection and doesn't respond well to chemo.

Small cell lung CA; non-small cell lung CA

10

What is a large cell carcinoma?

tumor that lacks glands, mucus production (adenocarcinoma), keratin pearls, or intercellular bridges (squamous cell carcinoma)

10

____ is the most common lung CA of female smokers.

Adenocarcinoma

11

This is a tumor of well-differentiated neuroendocrine cells that is chromogranin positive.

a carcinoid tumor

12

If a lung tumor involved the recurrent laryngeal nerve, the pt would present with _____.

hoarseness

13

What do lung metastases look like?

multiple cannon-ball nodules

14

This is a tumor of the small airways arising from the Clara cell of the lung.

bronchioloalveolar carcinoma

15

This is an obstruction of the SVC causing distended neck veins, edema, and blue hue to the face and arms.

Superior Vena Cava Syndrome

16

This is a tumor consisting of keratin pearls or intercellular bridges.

squamous cell carcinoma

17

This tumor forms a polyp-like mass in the bronchus.

carcinoid tumor

19

What are the 2 types of lung carcinomas?

  • small cell (15%)
  • non-small cell (85%)

20

What does a carcinoid tumor look like?

a polyp-like mass in the bronchus

20

If a lung tumor involved the phrenic nerve, the pt would present with _____.

diaphragmatic paralysis

21

If a lung tumor involved the _____, the pt would present with diaphragmatic paralysis.

phrenic nerve

21

What is a lack of sweat, especially on the forehead, called?

anhidrosis

22

What is bronchioloalveolar carcinoma?

a tumor of the small airways arising from the Clara cell of the lung

23

Where does lung CA commonly metastasize to?

the adrenal gland

24

Name the 2 neuroendocrine lung tumors.

1. small cell carcinoma 2. carcinoid tumors

25

What is Superior Vena Cava Syndrome?

obstruction of the SVC causing:

  • distended neck veins
  • edema
  • blue hue to the face and arms

27

What is present in cigarette smoke that makes it high risk for lung cancer development?

polycyclic aromatic hydrocarbons and arsenic

28

What is the average age at presentation for lung CA?

60yo

30

What are the risk factors for lung CA?

smoking, radon, asbestos

32

Where does radon come from?

radioactive decay of uranium

33

What are the most common sources of metastases to the lung?

breast and colon carcinomas

35

____ lung tumors are located peripherally.

Adenocarcinoma and bronchoalveolar

36

This is benign mass comprised of tissue native to that location that is disorganized.

hamartoma

38

What is Eaton-Lambert Syndrome?

development of Abs to pre-synaptic Ca++ channels, resulting in muscle weakness

39

Squamous cell carcinoma of the lung may produce ____ hormone, causing ____.

PTHrP, hypercalcemia

41

_____ causes squamous cell carcinoma of the lung.

Arsenic

42

What is an adenocarcinoma?

tumor consisting of glands and/or mucus production

44

This is a tumor consisting of glands and/or mucus production.

adenocarcinoma

45

What is a carcinoid tumor?

a tumor of well-differentiated neuroendocrine cells that is chromogranin positive

46

What do TNM stand for in TNM staging?

  • T = size and local extension of the tumor
  • N = spread to lymph nodes
  • M = metastasis

47

What is the most common cause of CA mortality in the US?

lung cancer

48

Small cell lung carcinoma is usually treated with _____, but non-small cell lung carcinoma is treated by _____.

chemo (not surgery); surgery (no chemo)

49

What is a hamartoma?

a benign mass comprised of tissue native to that location that is disorganized

50

What is the prognosis for large cell carcinoma?

poor

52

What is anhidrosis?

lack of sweat, esp on the forehead

53

Compression of the sympathetic chain by lung CA causes _____.

  • ptosis
  • pinpoint pupils
  • anhidrosis

54

What causes granulomas?

  • TB
  • fungi
  • histoplasma

55

This disease is caused by the development of Abs to pre-synaptic Ca++ channels, resulting in muscle weakness.

Eaton-Lambert Syndrome

56

How does lung CA look on imaging?

a solitary nodule