Tumor Markers Flashcards Preview

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Flashcards in Tumor Markers Deck (11):
1

Alkaline phosphatase

Metastases to bone, liver, Paget disease of bone,
seminoma (placental ALP).

2

α-fetoprotein

Normally made by fetus. Hepatocellular
carcinoma, hepatoblastoma, yolk sac
(endodermal sinus) tumor, testicular cancer,
mixed germ cell tumor (co-secreted with
β-hCG).

3

β-hCG

Hydatidiform moles and Choriocarcinomas
(Gestational trophoblastic disease), testicular
cancer

4

CA-15-3/CA-27-29

Breast cancer

5

CA-19-9

Pancreatic adenocarcinoma

6

CA-125

Ovarian cancer

7

Calcitonin

Medullary thyroid carcinoma

8

CEA

CarcinoEmbryonic Antigen. Very nonspecific
but produced by ∼ 70% of colorectal and
pancreatic cancers; also produced by gastric,
breast, and medullary thyroid carcinomas.

9

PSA

Prostate-specific antigen. Used to follow prostate
adenocarcinoma. Can also be elevated in BPH
and prostatitis. Questionable risk/benefit for
screenin

10

S-100

Neural crest origin (e.g., melanomas, neural
tumors, schwannomas, Langerhans cell
histiocytosis).

11

TRAP

Tartrate-Resistant Acid Phosphatase (TRAP).
Hairy cell leukemia—a B-cell neoplasm