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Flashcards in Uworld Exam 9 Deck (59):
1

Nissel Substance shows the prescence of?

RER

2

Kinesin facilitates what? And what else is required for kinesin to move?

Facilitates anterograde secretory vesicles movement

3

What do Desmosomes do? What disease manifests itself in this?

mediate cell to cell adhesions; Pemphigus Vulgaris

4

Overexpression of Bcl-2 leads to? And in what disease do you see this in? What is its translocation?

Increased survival of the cell
Follicular Lymphoma t14;18

5

What is CATCH 22 Stand for?

Cleft lip and palate, Abnormal facies, thymic hypoplasia, Cardiac Abnormality (tetralogy of fallot), Hypocalcemia, Long arm of Chr. 22

6

How do you treat Hyperthryoid eye problems?

High Dose Glucocorticoids, conventional antithyroid drugs don't fix it

7

Low grade fever and a maculopapular rash that spreads from the face and chest to the trunk and extremities, postauricular lymphadenopathy. Dx?

Rubella

8

Mother's Rubella are highest risk to get? What about the fetus?

Polyarthralgia=mom; baby=deafness

9

Eczematous skin rash, recurrent infection and thrombocytopenia that only affects males; Dx?

Wiskott-Aldrich Syndrome

10

Urine Discharge from umbilicus?

Persistent allantois remanent

11

Spironolactone MOA?

MOA: aldosterone receptor inhibitor

12

Type 1 slow fibers have high or low myoglobin and glycogen? and Examples? Aerobic or anaerobic metabolism?

myoglobin rich and glycogen poor
Aerobic
i.e. paraspinal muscles

13

Finasteride MOA?

5 alpha reductase inhibitor

14

Prognosis of CRC is dependent on stage or grade?

stage

15

Potassium Perchlorate MOA?

MOA: Inhibits Sodium Iodide Co-transporter

16

Varcose veins are due to?

incompetent venous valves

17

snRNPs do what? What makes them? Where are they made?

snRNP=>splices introns; RNA polymerase II and in the nucleus

18

Recurrent pulmonary infections in a Caucasian most likely suggests?

Cystic Fibrosis

19

In CF what changes do you see in the lungs, pancreas, nose,

Lungs=>thicker secretions=>bronchiectasis
Pancreas=>malabsorption (no pancreatic enzymes)

20

A patient comes in with generalized muscle stiffness and shaking hand. Doctor suspects drug induced. Which drugs induce it? MOA of these symptoms?

MOA: D2 blockade nigrostratial pathway
Cogwheel Rigidity of the ARM
Antipsychotics
Reserpine
Metoclopramide

21

What is DOC for drug induced parkinsonism?

Anticholinergics (Benztropine, trihexiphenyl) Or Amantidine

22

What does orthopnea show?

There is a left sided heart failure

23

What are signs of R. sided Heart failure?

Hepatosplenomegaly and lower extremity edema

24

Etoposide MOA?

MOA: Inhibits sealing activity of Top Isomerase II

25

What does Topoisomerase I do?

creates single stranded nicks to relieve neg. supercoiling

26

What does Topoisomerase II do?

Creates double stranded nicks to relieve pos. and neg. supercoiling

27

A patient with an urge to move the legs when falling asleep and "difficult to describe" sensation of the legs. Dx?

Restless Leg Syndrome

28

Restless Leg Syndrome is more common in those with?

Iron deficiency

29

DOC for Restless Leg Syndrome?

Dopamine Agonist

30

Replacement of Prosthetic Value. What bug should you think of?

Staph Epidermidis

31

Catalase differentiates?

Staph from Strep (Cat seperates big groups)

32

Coagulase seperates?

Staph Aureus from other staph (like S. Epi)

33

In what disease do you get repeated infection of Catalase + organisms?

Chronic Granulomatous Disease

34

MOA of Chronic Granulomatous Disease?

Def. of NADPH oxidase and get repeated infection of Catalase+ organisms

35

List the Catalase+ organisms?

Catalse + organisms go into CGD's SPACE
Staph
Pseudomonas
Aspergillus
Candida
Enterobacter

36

A patient has a diarrheal infection and arthritis. Yet there is no bacteria in the joint aspriation and ibuprofen relieves the pain. Dx?

Reactive Arthritis (HLA-B27 Spondoarthryopathy)

37

Reactive Arthritis occurs after an infection of?

Campy Salmon Yersinia Bartonella Shigella

38

Everytime GFR doubles what happens to serum creatinine?

It halves

39

In Sickle Cell Patients, what should you immediately think?

They are asplenic

40

Asplenic Patients are prone to getting what kind of organisms?

Encapsulated organisms

41

What are the Encapsulated organisms?

SHINE SKIS
Strep Pneumoniae
Haemophilus Influenza
Neisseria
Ecoli
Salmonella
Klebsiella
Group B Strep

42

Out of the encapsulated organisms which ones are especially important in asplenic/sickle cell patients?

SHiN
Strep Pneumoniae>Haemophilus>Neisseria

43

Sickle Cell patients are more prone to get what disease? What bug should you be thinking of?

Osteomyelitis, Salmonella

44

What is molecular problem in Cystic Fibrosis? What does this result in?

3 base pair deletion in CFTR that removes phenylalanine at position 508;=>impairs posttranslational modifications and shunts CFTR to proteosomes

45

In primary hyperaldosteronism, what are the renin and aldosterone levels?

Ald=High; Renin=low

46

What are some causes of high renin and aldosterone levels?

Reninoma
Renal Artery Stenosis
Malignant HTN
Diruetics

47

CAH causes what kind of renin and aldosterone levels?

Low Low

48

What are the two pathways that homocysteine can be changed to non toxic forms? What are its enzymes and cofactors?

1. Homocysteine METHYLtransferase w/B12=>Methionine
2. Cystathionine Synthase w/B6=>cystathionine>>cysteine

49

What are symptoms of hyperaldosteronism?

Weakness, parethesia=>low K+ (in principal cells); Increased H+ secretion=>metabolic alkalosis (in alpha intercalated)

50

ACE inhibitors MOA?

Inhibits Efferent renal arterioles

51

When does Tumor Lysis Syndrome Occur?

When there is high cell turnover in patients who are doing chemotherapy

52

What is most worrisome in the kidney with a tumor lysis syndrome?

Uric Acid Crystals

53

At what pH do uric acid crystals precipitate? Where is that in a nephron?

When it is acidic; near the collecting ducts (most acidic)

54

Dysphagia and disfigured nails (kolionychia) are symptoms of?

Iron Def. Anemia

55

In what syndrome do you see involvement of dysphagia and iron def. anemia?

Plummer-Vinson Syndrome

56

What is the triad in Plummer-Vinson Syndrome?

Dysphagia, Iron Def. Anemia, Esophageal web

57

What is the most feared complication in Plummer-Vinson Syndrome?

Predisposition to Squamous Cell Carcinoma

58

What drugs cause Torsades De Pointes?

Class III, IA, Macrolides, antipsychotics, TCAs

59

Where is Transketolase found? What is it most useful for?

Cytoplasm; To find out if the patient has Thiamine def. (only one that has just TPP); look for elevated RBC transketolase activity