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Flashcards in Uworld Exam 8 Deck (47):
1

What does this picture show? In what disease, do you famously see this?

Q image thumb

Reactive CD8 T cell Lymphocytes; EBV

2

MIF Inhibits?

Female Internal Structures: Tubes Uterus Cervix, 1/3 of vagina

3

How do you calculate Relative Risk?

Incidence of the exposed/Incidence of unexposed

4

ECG shows HR 120 beats/min, irregular rhythm, narrow QRS complexes and no P waves. What is the problem?

Atrial Fibrillation

5

Acyclovir MOA? EBV/CMV vs HSV/VZV?

MOA: Guanosine analog that is activated into active triphosphate form via Thymidine kinase

In HSV and VZV, this kinase is produced but in EBV and CMV=>it is not produced

 

6

IL-4's function? 

Class switching for IgE and IgD

7

Why is there only a modest increase in BP when a patient exercises?

vasodilation within muscles

8

In an eukaryotic cell, if there is a DNA molecules that resemble bacterial chromosomes, you should think it is from? 

mitochondria

9

Hyperphagia and obesity, what nucleus?

ventromedial

10

How would PO2, % saturation, and O2 content change with anemia, CO poisoning and polycythemia?

Anemia: PO2 and % saturation=Normal; O2 content=decreased

Polycythemia: PO2 and % saturation=Normal; O2 content=increased

CO Poisioning: PO2=Normal; % saturation and O2 content decreased

11

Patient has ABG of pH 7.59, pCO2 49 mmHg, and pO2 85? What kind of an acid base disorder does this patient have? What is the next best test of choice?

Metabolic Alkalosis, Check Urine chloride

12

A Patient has flushing, purple vascular lesions, watery diarrhea, bronchospasm w/abdominal tumor in the small intestine.  Elevated Urine 5 HIAA.  What is the Dx? and Tx?

Metastatic Carcinoid Tumor

Tx: Octreotide-Somatostatin Analog

 

13

Mortality Cancer in US for men and women?

men=LBC

women=LPC

14

MC inherited hypercoagulable (thrombophilic) disease?

Factor Leiden V 

15

1 week old boy is vomiting and poorly feeding.  The boy is dehydrated. Na+ 122 mEq/L.  What is the mostly likely Dx?

Congenital Adrenal hyperlasia

16

MC Congenital Adrenal Hyperplasia? What symptoms do you see in this disease?

21 hydroxylase def.=>Latter number=1=>increase in androgen synthesis

Cortisol, aldosterone synthesis decreased 

17 progesterone elevated 

serum ACTH elevated

17

What do you see in a patient with 17 hydroxylase def.?

Normal Kids with severe HTN.

18

In a female patient with 21 hydroxylase def., what do you see?

Increased virilization

19

Glucagon MOA in myocytes?

Increased cAMP and increased Ca2+ in cardiac myocytes

20

What will you see in the lumbar puncture of a patient with Cryptococcus? TOC for acute and long term?

Low Glucose, and increased protein, usually grown on sabouraud agar

TOC acute: amphotericin B 

Long Term: Azole

21

Hypoxathine is converted to Uric Acid by? What drug inhibits this?

Xanthine Oxidase; Allopurinol

22

Long Term Drugs for Gout?

Uricosuric agents: Probenicid or sulfinpyrazone

Xanthine Oxidase Inhibitors: Allopurinol

 

23

Probenecid MOA? Use? AE? 

MOA: inhibits reabsorption uric acid in the proximal convoluted tubules

Use: Chronic Gout in patients with good renal function

AE: Uric Acid Stones (Caliculi)

24

Allopurinol MOA? Use?

MOA: Xanthine Oxidase Inhibitor

Use: Chronic Gout

25

MC prosthetics, shunt placement and catheter bug?

Staph Epidermidis

26

What Immunoglobulin cannot cross the placenta?

IgM

27

What disease is a benign epidermal tumor that presents as a tan to brown, round, flat coin-like lesion that looks like it can be scrapped off (stuck on appearance)?

Seborrheic Keratosis

28

IV drug user with high grade fever, fatigue and dyspnea with hemmorhagic infarc in the lungs.  Dx?

Tricuspid Endocarditis by S. Aureus

29

Okazaki fragments are put together by?

DNA Ligase

30

Pencillin and Cephalosporin MOA? Resistance?

MOA: Binds to PBP irreversibly and inhibits transpeptidases

Resistance: Through Protein structural change

31

HBcAg makes what kind of proteins? And where is it?

Core protein=>hepatocytes

 

 

32

Glycoprotein that forms spheres and tubules that is about 22 nm in diameter that poorly correlates with viral replication is associated with what antigen?

HBsAg

33

With Statins, MC adverse effect and what should you check?

Rhabdomyolysis and LFTs

34

Sudden, painless, onesided blindness with cherry red macula.  Dx?

Central retinal artery occlusion

35

Alpha 1 adenergic stimulation can cause reflex?

bradycardia

36

Flattened Face, epicanthal folds and endocardial cushion defect.  MOA?

Down Syndrome: Nonmeiotic disjunction

37

Chewing difficulty, persistent headaches, and tenderness over the temples. Dx?

Temporal Giant Cell arteritis

38

Hemoglobin of 9.0 g, increased LDH and indirect bilirubin increased.  

hemolyic anemia

39

RBCs incubated hypotonic saline, hemoglobin is released. What test is it? and what is specific for? MOA of the disease?

 

Positive osmotic fragility Test; Hereditary Spherocytosis (AD)

MOA: Spectrin and ankrin def.

40

With any hemolytic anemia, the patient is at an increased risk of developing what?

Pigmented Gallstones

41

MC neurological complication of VZV?

Post Herpetic Neuralgia

42

Asbestos workers are more likely to get what kind of cancer?

Bronchogenic Carcinoma>Mesothelioma

43

Female with exertional dyspnea has inherited condition.  Mostly likely MOA of her disease?

BMPR2=>Vascular smooth muscle proliferation

44

Hypotensive, tachycardic, hypoglycemic, with vomiting and weight loss you should think? DOC?

Adrenal Crisis (b/c of adrenal insufficiency)

DOC: Glucocorticoids

45

Hx of travel, Anorexia, nausea, dark urine, low grade fever and mild right upper abd. quadrant tenderness suggests? A Bx is likely to show which of the following?

Acute Viral Hepatitis, 

Bx: Diffuse Ballooning degeneration, mononuclear cell infiltrates, and councilman bodies

46

What is the haldane effect and where does it occur? What is opposite to this effect and where does that occur?

  

Haldane effect=>increases in O2 leads to CO2 and H+ unloading; in the lungs

Bohr Effect=>peripheral tissues

47

Primary Ammenorhea in a patient with fully developed secondary sexual characteristics suggests the presence of? MCC of this presence is?

Anatomic defect MC=>imperforated hymen