Uworld Exam 5 Flashcards Preview

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Flashcards in Uworld Exam 5 Deck (27):
1

Amitriptyline MCC of Death?

cardiac arrhythmias=>inhibit fast sodium channel

2

Calcineurin MOA?

dephosphorylates NFAT (nuclear factor of activated T-cells)=>binds to IL-2

3

What drugs inhibit NFAT?

Cyclosporine and Tacrolimus

4

T-Tubules function?

To transmit a rapid and uniform contraction

5

Fatigue, weight loss+polyuria/polydipsia; What should you check?

DM; Check Fasting Glucose levels

6

Abdominal Pain, Confusion, Nausea, Urine Reddish Color?

Acute Intermittent Porphyria

7

Next Step in Management for Acute Intermittent Porphyria?

IV dextrose or Heme

8

Acute Intermittent Porphyria; what enzyme is deficient and what do you get a buildup of?

Porphobilinogen deaminase def. (build up of Porphobilinogen)

9

MCC of bacterial Meningitis in all adults?

Strep Pneumo

10

Case control vs Cohert studies?

Case Control=>start with disease then look for exposures

11

Alpha 1 controls?

Skin (blood vessels), Urinary sphincter (contracts), Eyes (mydriasis)

12

Beta 2 controls?

Lungs and Uterus (dilation/relaxation)

13

Increase ALP? Look for?

Gamma-glutamyltransferase

14

Hypophosphorylated Retinoblastoma

active state=>prevents it going from G1=>S

15

First Diuretic used for CHF?

Loop diuretic

16

MCC of cellulitis?

#1 staph, #2 strep

17

H. Pylori

Causes Duodenal Ulcers
Dx: Carbon Urea Test

18

Collagen vs Elastin

Collagen=>(1) Triple helix (2) Extramodifications (hydroxylation, glycosylation and assembly)

Elastin=>(interacts with fibrillin)=>lysine residues create a desmosine crosslink

19

Gallstones MC in?

Fat, Female, Fertile, Forty

20

In pregnancy gallstones, MOA?

MOA:
(1) Estrogen=>upregulates HMG-CoA reductase=>cholesterol in bile;
(2) Progesterone=>Gallbladder hypomotility=>slows bile acid secretion and slows bladder emptying

21

Radiation MOA?

MOA:
(1) dsDNA breaks
(2) Free radical production

22

What other disease causes dsDNA breaks?

Ataxia-telangiectasia

23

Respiratory stratified squamous epithelium

oropharynx, laryngeopharynx, anterior epiglottis, post. Epiglottis and true vocal cords

24

VPL, VPM, LGB, MGB?

VPL=Pain and Temperature, Position and proprioception; Spinothalamic and Medial Lemniscus
VPM=>little kids eat sweets=>trigeminal and gustatory to primary sensory cortex (Broca 3, 1&2)
LGB-To look at Long Legs=>Long optic nerve to optic radiations (calcarine sulcus)
MGB=>Music Pathway=>temporal lobe (Broca 41, 42)

25

Bleeding after tooth extract and hemarthrosis (joint bleeding)?

Hemophilia
Tx: Thrombin

26

Relative Risk Reduction

Absolute risk control-Absolute risk experiment)/absolute risk of control

27

How do you increase Availability of a gene?

Increased acetylation, DNA hypomethylation