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Flashcards in Uworld Exam 10 Deck (60):
1

What Hepatitis should you think in a pregnant patient?

Hep E

2

What kind of virus is Hep E? What is its risk in pregos?

Unenveloped, ssRNA virus spread through fecal oral route; can lead to pregnant patient death

3

What is the main purpose of a double blind experiment

stop observer's bias

4

Difference between Minute volume and alveolar volume?

Alveolar volume subtracts dead space

5

What translocation is associated with t15;17?

AML M3

6

What is the molecular MOA of t15;17?

Translocation of retinoic acid recetor from chr. 17 to 15 leads to PML/RAR alpha=>inhibits differentiation of myeloblasts

7

NF type 1 is what kind disorder? What chromosome is it on?

single gene AD on Chr. 17

8

Most common symptoms of NF1

Cafe-au-lait spots, Neurofibromas, Lisch Nodules (harmatomas of the eye)

9

Description for Type 1 HSR?

Cell surface-bound IgE Bridging by an antigen

10

What is superior mesenteric syndrome?

Transverse portion of the duodenum is entrapped between SMA and the aorta=>decreases angle of between SMA and aorta

11

Polyhydramnios is associated with what kind of diseases?

GI obstructions and aneuncephaly

12

Infant whose epidermis easily peels off?

Scalded Skin Syndrome

13

What causes Scaled skin syndrome? What is the specific agent in the bug that causes this?

Staph; +nikolskys sign, exfoliatin exotoxin

14

How does Exfoliatin exotoxin work?

uses proteases to cleave desmoglein from desmosomes

15

What is genetic defect in CML?

Fusion of 9 and 22=>BCR-ABL gene

16

BCR-ABL gene encodes for what kind of receptor?

Tyrosine Kinase receptor

17

Nitrates MOA? AE?

MOA: Dilates veins
AE=Dilating veins and arteries too much=>headache, flushing

18

What reflects osteoblastic activity?

Increased ALP

19

What structure goes through the pterion? What is this structure a branch of?

Middle Meningeal Arteries=>from maxillary arteries

20

Coronary Plaques more than what cause symptoms?

75%

21

Which nerve travels with the inferior thyroid artery?

recurrent laryngeal nerve

22

What vitamin is effective in treating measles?

Vit. A

23

Aldolase B is used for converting what sugar?

Fructose

24

Sucrose? Maltose? Lactose? break up into?

Sucrose=Fructose+glucose
Maltose=Glucose+glucose
Lactose=glucose+galactose

25

CPS 1 is an enzyme for which cycle? What is its obligate co-factor

Urea Cycle; N-acetylglutamate

26

Young Caucasian woman with increased coagulability, and resistant to activated protein C in plasma?

Factor Leiden V

27

Integral Membrane proteins have alpha helices of hydrophobic amino acid residues such as

valine, alanine and isoleucine

28

Triad of symptoms in pericardial tamponade

Muffled heart sounds, elevated JVP and profound hypotension

29

Explain 1 day 1 week 1 month

1st day=>coagulative necrosis
1st week=>Neutrophil=>Macrophage (inflammation_
1 month=>Granulation Tissue
After that=>Scar Tissue

30

With DM neuropathy, what would you see bladder wise?

Increased postresidual volume

31

Which drug has been shown to decrease mortality in all patients with any CHF?

B-Blocker

32

DOC for DVT in Pregos?

Heparin

33

DOC for DVT in Regular patients?

Warfarin

34

Patient's blood rapidly coagulates with cold and uncoagulates with warmth, most likely bug?

mycoplasma pneumoniae

35

Patients over the age 65 are most prone to secondary?

pneumonia

36

What are the bugs that cause secondary pneumonia, in order?

strep pneumoniae, staph aureus, H. influ

37

Subdural hematoma+bilateral retinal damages?

Shaken Baby Syndrome

38

AE of HIV-1 protease inhibitors?

Redistribution of fat from extremities to abdomen

39

Cladribine MOA? Use? metabolism?

MOA: purine analog=>DNA strand breaks
Use: Hairy Cell Leukemia
Metabolism=resistant to adenosine deaminase

40

Two formulas for RBF?

FF=GFR/RBF; RBF=PAH clearance/(1-hematocrit)

41

MC movement disorder?

Essential Tremor

42

Symptoms of essential tremor?

symmetrical tremor that affects upper extremities

43

DOC for essential tremor?

Propanolol

44

MC shigellosis in US?

Shigella Sonni

45

Shigella invades what cells?

M cells in Peyer's Patches in ileum

46

Capcitiation

Money is by each enrollee not fee

47

Overuse of alpha adenergic agonistic decongestants cause?

Tachyphylaxis=>decreased production of endogenous NE; the drug is not effective anymore=>so stop it

48

A neonate with jaundice, hepatosplenomegaly, anemia and edema with extramedullary hematopoesis?

Hemolytic disease of the newborn (erythroblastosis fetalis)

49

MCC of Hemolytic Disease of the new born?

Rh incompatibility

50

Hemidesimosome Ab?

bullous pemphigoid

51

46 XY with Small Phallus and hypospadias but becomes better in puberty

5 alpha reductase def.

52

Sickle Cell Trait person is what percentage HbS?

40%

53

Sickle Cell Homozygous person has what percentage of Hbs?

80%

54

In both homozygous and heterozygous do the cells sickle when sodium metabisulfate is added?

Yes

55

Sickle cell trait patient has relative protection from?

P. Falciparum (malaria)

56

Which markers reflect osteoclastic activity?

Tartarate-resistant acid phsophatase, urinary hydroxyproline and urinary deoxypyridinoline (Most Reliable)

57

Inulin Filtered vs Excreted ratio?

The same

58

How much of urea is reabsorbed?

50%

59

How much of sodium is reabsorbed?

99%

60

PAH Filtered vs excreted?

Excreted would be higher because it is almost all secreted