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Flashcards in Uworld Exam 4 Deck (23):
1

What are fatty streaks? And do they predict atherosclerotic location?

Intracellular lipid accumulations=>but do not predict where atherosclerosis will happen.

2

MC Microcytic, hypochromatic anemia?

Iron Deficiency

3

Patient w/adrenal outer layer tumor, most likely symptom?

Hyperaldosteronism=>increased Na+ retention and K+secretion=>HTN and hypokalemia and alkalosis (H+ also secreted)=> think parathesia and muscle weakness

4

Cytokeratin + means?

Epithelial cells

5

HER2/neu receptors are what kind of receptors?

Tyrosine Kinase=>Growth factor receptor

6

Patient w/Recurrent episodes of sudden onset headaches followed by transient period then another headache. Next Step in Management?

24 hr urine metanephrines for Pheochromocytoma

7

Flat Facial features, and excessive skin in the back w/ VSD and duodenal atresia

Down Syndrome

8

SSRI MC AE?

AE: sexual dysfunction

9

OCP MOA?

decreased GnRH

10

Uteric Bud makes what structures? Metanephric Mesoderm (blastema)?

Uteric Bud=>Collecting Tubules=>ureters
Metanephric Mesoderm (blastema)=> Glomerulus=>DCT

11

Rheumatoid Factor?

IgM Fc Region of human IgG (Non specific), anti-CCP (more specific)

12

Albinism, neurologic deficits and immunodeficiency. Dx? MOA of Dx? Bx?

Chediak-Higashi; MOA: Lysosomal fusion defect; Bx: giant cytoplasmic granules

13

Amitriptyline AE?

Cardiac arrythmias+antimuscarinic toxicity

14

Drugs in Drug induced lipids? What marker will be +? How are they metabolized in the body?

SHIPP (Sulfonamides, Hydralazine, Isonazid, Procainamide, Phenytoin); Antihistone ab
N-Acetylation in the Liver

15

Attributable risk percent in the exposed?

-Shows excess risk in the exposed population
ARP=100* (RR-1/RR)

16

Formula for Filtration Fraction?

FF=GFR/RPF

17

Without progesterone, endometrial lining sheds by what process?

apoptosis

18

A patient suddenly decelerates (“rear ending a vehicle”); There is a tear in which part of the aorta?

Isthmus of aorta

19

Best Test for asthma

methacholine challenge test

20

Best Test for asthma

methacholine challenge test

21

Multiple family members getting sick eating the same ethnic meal. The causal agent produces a spore, MOA?

Clostridium Botulinum=>Preformed Exotoxin**
MOA: Cleaves SNARE protein and blocks binding and fusion of Ach vesicles with plasma membrane=>inhibits the presynaptic release of Ach

22

Baby eats a jar of honey and gets Flaccid paralysis. What is the MOA of the casual agents' virulence?

Clostridium Botulinum=>Ingestion of Spore**

23

Smoker w/SOB and cough and calcium elevated. What is the reason for elevated calcium?

Lung cancer (SCLC) that secretes parathyroid hormone related peptide (PTHrP)=>Most significant increase in hypercalcemia in malignancy