Uworld Exam 4

Question 1

What are fatty streaks? And do they predict atherosclerotic location?

Answer 1

Intracellular lipid accumulations=>but do not predict where atherosclerosis will happen.

Question 2

MC Microcytic, hypochromatic anemia?

Answer 2

Iron Deficiency

Question 3

Patient w/adrenal outer layer tumor, most likely symptom?

Answer 3

Hyperaldosteronism=>increased Na+ retention and K+secretion=>HTN and hypokalemia and alkalosis (H+ also secreted)=> think parathesia and muscle weakness

Question 4

Cytokeratin + means?

Answer 4

Epithelial cells

Question 5

HER2/neu receptors are what kind of receptors?

Answer 5

Tyrosine Kinase=>Growth factor receptor

Question 6

Patient w/Recurrent episodes of sudden onset headaches followed by transient period then another headache. Next Step in Management?

Answer 6

24 hr urine metanephrines for Pheochromocytoma

Question 7

Flat Facial features, and excessive skin in the back w/ VSD and duodenal atresia

Answer 7

Down Syndrome

Question 8

SSRI MC AE?

Answer 8

AE: sexual dysfunction

Question 9

OCP MOA?

Answer 9

decreased GnRH

Question 10

Uteric Bud makes what structures? Metanephric Mesoderm (blastema)?

Answer 10

Uteric Bud=>Collecting Tubules=>ureters
Metanephric Mesoderm (blastema)=> Glomerulus=>DCT

Question 11

Rheumatoid Factor?

Answer 11

IgM Fc Region of human IgG (Non specific), anti-CCP (more specific)

Question 12

Albinism, neurologic deficits and immunodeficiency. Dx? MOA of Dx? Bx?

Answer 12

Chediak-Higashi; MOA: Lysosomal fusion defect; Bx: giant cytoplasmic granules

Question 13

Amitriptyline AE?

Answer 13

Cardiac arrythmias+antimuscarinic toxicity

Question 14

Drugs in Drug induced lipids? What marker will be +? How are they metabolized in the body?

Answer 14

SHIPP (Sulfonamides, Hydralazine, Isonazid, Procainamide, Phenytoin); Antihistone ab
N-Acetylation in the Liver

Question 15

Attributable risk percent in the exposed?

Answer 15

-Shows excess risk in the exposed population

ARP=100* (RR-1/RR)

Question 16

Formula for Filtration Fraction?

Answer 16

FF=GFR/RPF

Question 17

Without progesterone, endometrial lining sheds by what process?

Answer 17

apoptosis

Question 18

A patient suddenly decelerates (“rear ending a vehicle”); There is a tear in which part of the aorta?

Answer 18

Isthmus of aorta

Question 19

Best Test for asthma

Answer 19

methacholine challenge test

Question 20

Best Test for asthma

Answer 20

methacholine challenge test

Question 21

Multiple family members getting sick eating the same ethnic meal. The causal agent produces a spore, MOA?

Answer 21

Clostridium Botulinum=>Preformed Exotoxin**
MOA: Cleaves SNARE protein and blocks binding and fusion of Ach vesicles with plasma membrane=>inhibits the presynaptic release of Ach

Question 22

Baby eats a jar of honey and gets Flaccid paralysis. What is the MOA of the casual agents’ virulence?

Answer 22

Clostridium Botulinum=>Ingestion of Spore**

Question 23

Smoker w/SOB and cough and calcium elevated. What is the reason for elevated calcium?

Answer 23

Lung cancer (SCLC) that secretes parathyroid hormone related peptide (PTHrP)=>Most significant increase in hypercalcemia in malignancy