Unit 2: Local Anesthetics and Opioid Analgesics Flashcards Preview

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Flashcards in Unit 2: Local Anesthetics and Opioid Analgesics Deck (44):
1

L1: Local anesthetic drugs with decreased lipophilicity have ______ potency.

decreased

2

L1: Local anesthetic drugs with decreased protein-binding capacity have ______ duration of action.

decreased

3

L1: Local anesthetic drugs with higher pKa have ______ duration of onset

increased

4

L1: Local anesthetic drugs with increased lipophilicity have ______ potency.

increased

5

L1: Local anesthetic drugs with increased protein-binding capacity have ______ duration of action.

increased

6

L1: Local anesthetic drugs with lower pKa have ______ duration of onset

decreased

7

L1: Opioid receptors _____ calcium channels.

inhibit

8

L1: Opioid receptors _____ cAMP synthesis

decrease

9

L1: Opioid receptors _____ potassium channels

activate

10

L1: Opioid receptors ___-polarize neurons.

Hyper

11

L1: Opioid receptors activate _____ channels.

Potassium

12

L1: Opioid receptors inhibit ______ channels.

Calcium

13

L1: Opioids inhibit ______-ergic neurons in the brain.

GABA

14

L2: _____ is a non-opioid drug used to treat opioid withdrawal symptoms.

Clonidine

15

L2: Name a drug that acts as an NMDA receptor antagonist.

Ketamine

16

L2: Name the morphine derivatives that have higher potency than morphine (2).

Oxymorphone, hydromorphone

17

L2: Which adjuvant medication? Used for diabetic neuropathy, migraine, low back pain, and post-herpetic neuralgia

Tricyclic Antidepressants

18

L2: Which adjuvant medication? Used for fibromyalgia

SNRIs

19

L2: Which adjuvant medication? Used for post-herpetic neuralgia and allodynia

Local topical anesthetics

20

L2: Which adjuvant medication? Used for spinal cord injury, trigeminal neuralgia, and diabetic neuropathy

Anticonvulsants

21

L2: Which endogenous agonist acts at delta-opioid receptors?

Enkephalins, Beta-endorphin

22

L2: Which endogenous agonist acts at mu-opioid receptors?

Beta-endorphin

23

L2: Which endougenous agonist acts at kappa-opioid receptors?

Dynorphin

24

L2: Which opioid drug acts as a partial mu-opioid receptor agonist?

Buprenorphine

25

L2: Which opioid drug also blocks monoamine reuptake?

Tramadol

26

L2: Which opioid drug can act at kappa-opioid receptors with no mu-opioid antagonism?

Pentazocine

27

L2: Which opioid drug is used in maintenance therapy for addiction to suppress withdrawal symptoms?

Methadone

28

L2: Which opioid functions to not develop physiologic tolerance?

Miosis, constipation

29

L2: Which opioid receptor induces anlagesia without respiratory depression?

Delta

30

L2: Which opioid receptor is responsible for spinal analgesia?

Kappa

31

L2: Which phenylpiperidine derivative has short duration of action and is often used as adjunct to surgical anesthesia?

Fentanyl

32

L3: List the three components of a local anesthetic structure.

Lipophilic aromatic ring, intermediate alkyl chain, hydrophilic amine

33

L3: What three classes of drugs have adverse reactions with opioid analgesics?

CNS depressants/barbiturates, Phenothiazines, MAOIs

34

L3: Which drug classes are used in pain management to block modulation? (3)

Opioids, NMDA-antagonists, alpha-2 adrenergic agonists

35

L3: Which drug classes are used in pain management to block transmission? (2)

local anesthetics, opioids

36

L3: Which drugs are used as epidural anesthetics? (2)

Lidocaine, bupivacaine

37

L3: Which drugs are used as infiltration anesthetics? (3)

Lidocaine, procaine, bupivacaine

38

L3: Which drugs are used as nerve block anesthetics?

Lidocaine

39

L3: Which drugs are used as spinal anesthetics? (3)

Lidocaine, bupivacaine, tetracaine

40

L3: Which opioid drugs act as kappa agonists and mu antagonists?

Butorphanol, Nalbuphine

41

L4: Name 4 phenypiperidine mu-opioid receptor agonists.

Meperidine, loperimide, diphenoxylate, fentanyl

42

L4: Name 8 phenanthrene mu-opioid receptors agonists.

Heroine, Morphine, oxymorphone, hydromorphone, codeine, oxycodone, hydrocodone, tramadol

43

L4: Which drug classes are used in pain management to block transduction? (4)

NSAIDs, COX-2 Inhbiitors, Anticonvulsants, local anesthetics

44

L4: Which drugs are used as topical anesthetics? (4)

Tetracaine, lidocaine, cocaine, benzocaine